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Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure

The Journal of pharmacology and experimental therapeutics, 1995-11, Vol.275 (2), p.745

1995

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N-formyl hydroxylamine containing dipeptides : Generation of a new class of vasopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 2000-02, Vol.10 (3), p.257-260

2000

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Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.305-311

1999

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Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1570-1577

1997

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A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Journal of medicinal chemistry, 2001-03, Vol.44 (6), p.851-856

2001

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Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.5025-5037

2005

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Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitors

Journal of medicinal chemistry, 1996-01, Vol.39 (2), p.494-502

1996

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Recent advances in the design and development of vasopeptidase inhibitors

Expert opinion on therapeutic patents, 1999-12, Vol.9 (12), p.1665-1677

1999

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An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits

Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5389), p.751-754

1998

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Instrumentation and Separation Results of Medium Pressure Liquid Chromatography

Journal of chromatographic science, 1987-11, Vol.25 (11), p.501-505

1987

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A synthetic route for the generation of C-7 substituted azepinones

Tetrahedron letters, 1994-02, Vol.35 (9), p.1393-1396

1994

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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2587-2598

2004

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Peptidomimetic synthesis: Utilization of N-acyliminium ion cyclization chemistry in the generation of 7,6- and 7,5-fused bicyclic lactams

Tetrahedron letters, 1994, Vol.35 (3), p.393-396

Robl, Jeffrey A.

1994

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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2804-2815

1991

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5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (20), p.5067-5070

2004

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General scope of 1,3-dioxolanation of α,β-unsaturated aldehydes with 1,2-bis((trimethylsilyl)oxy)ethane and trimethylsilyl trifluoromethanesulfonate

Journal of organic chemistry, 1987-01, Vol.52 (2), p.188-191

1987

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Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (18), p.3992-3995

2005

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An efficient method for the generation of N-methylnitrones

Journal of organic chemistry, 1985-12, Vol.50 (26), p.5913-5916

1985

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Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1799-1802

2005

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Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1337-1340

2003

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A new versatile route for the synthesis of highly substitued benzenoids

Tetrahedron letters, 1990, Vol.31 (24), p.3421-3424

ROBL, J. A

1990

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A general synthesis of dioxolenone prodrug moieties

Tetrahedron letters, 2002-02, Vol.43 (7), p.1161-1164

2002

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Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams

Journal of the American Chemical Society, 1994-03, Vol.116 (6), p.2348-2355

1994

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Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.2952-2956

1990

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Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure

N-formyl hydroxylamine containing dipeptides : Generation of a new class of vasopeptidase inhibitors

Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides

Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors

Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitors

Recent advances in the design and development of vasopeptidase inhibitors

An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits

Instrumentation and Separation Results of Medium Pressure Liquid Chromatography

A synthetic route for the generation of C-7 substituted azepinones

Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Peptidomimetic synthesis: Utilization of N-acyliminium ion cyclization chemistry in the generation of 7,6- and 7,5-fused bicyclic lactams

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

General scope of 1,3-dioxolanation of α,β-unsaturated aldehydes with 1,2-bis((trimethylsilyl)oxy)ethane and trimethylsilyl trifluoromethanesulfonate

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

An efficient method for the generation of N-methylnitrones

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents

A new versatile route for the synthesis of highly substitued benzenoids

A general synthesis of dioxolenone prodrug moieties

Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

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