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Development of Second-Generation VEGFR Tyrosine Kinase Inhibitors: Current Status

Current oncology reports, 2011-04, Vol.13 (2), p.103-111

2011

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Functional Conservation of the Telomerase Protein Est1p in Humans

Current biology, 2003-04, Vol.13 (8), p.698-704

2003

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A Mammalian Telomerase-Associated Protein

Science (American Association for the Advancement of Science), 1997-02, Vol.275 (5302), p.973-977

1997

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Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.7022-7027

2009

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Human-in-Mouse breast cancer model

Cell cycle (Georgetown, Tex.), 2009-08, Vol.8 (15), p.2317-2318

2009

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Preferential Maintenance of Critically Short Telomeres in Mammalian Cells Heterozygous for mTert

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3597-3602

2002

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Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

Nature biotechnology, 2010, Vol.28 (1), p.71-78

2010

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Reconstitution of human telomerase activity in vitro

Current biology, 1998-01, Vol.8 (3), p.177-180

1998

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Human telomerase contains evolutionarily conserved catalytic and structural subunits

Genes & development, 1997-12, Vol.11 (23), p.3109-3115

1997

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Functional Multimerization of the Human Telomerase Reverse Transcriptase

Molecular and Cellular Biology, 2001-09, Vol.21 (18), p.6151-6160

2001

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De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

Cancer research (Chicago, Ill.), 2009-12, Vol.69 (23), p.8949-8957

2009

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The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

Neoplasia (New York, N.Y.), 2000-09, Vol.2 (5), p.426-432

2000

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Vaults and Telomerase Share a Common Subunit, TEP1

The Journal of biological chemistry, 1999-11, Vol.274 (46), p.32712-32717

1999

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Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human Cancers

Molecular and Cellular Biology, 1999-01, Vol.19 (1), p.612-622

1999

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Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

Molecular biology of the cell, 2000-10, Vol.11 (10), p.3329-3340

2000

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Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

Molecular and Cellular Biology, 2000-11, Vol.20 (21), p.8178-8184

2000

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Genes & development, 1999-09, Vol.13 (18), p.2388-2399

1999

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Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis

Nucleic acids research, 1990-03, Vol.18 (5), p.1255-1259

1990

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Telomere dysfunction: multiple paths to the same end

Oncogene, 2002-01, Vol.21 (4), p.592-597

2002

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Telomere dysfunction: multiple paths to the same end

Oncogene, 2002-01, Vol.21 (4), p.592-597

2002

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Abstract 2000: Biological function annotation of microarray data using correlated gene indices

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2000-2000

2010

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Abstract A5: Tivozanib, a selective VEGFR TKI, potently blocks angiogenesis and growth in tumors that express a high level of VEGF-C and are refractory to VEGF-A blockade

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A5-A5

2011

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Abstract 1727: Preclinical evaluation of pan-VEGFR inhibitor tivozanib in combination with capecitabine, sirolimus or erlotinib in genetically engineered tumor models support combinations based on complementary mechanisms

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.1727-1727

2011

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Population-based engineered tumor models as a platform for biomarker discovery in cancer

Clinical cancer research, 2010-10, Vol.16 (19_Supplement), p.B10-B10

2010

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Development of Second-Generation VEGFR Tyrosine Kinase Inhibitors: Current Status

Functional Conservation of the Telomerase Protein Est1p in Humans

A Mammalian Telomerase-Associated Protein

Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

Human-in-Mouse breast cancer model

Preferential Maintenance of Critically Short Telomeres in Mammalian Cells Heterozygous for mTert

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

Reconstitution of human telomerase activity in vitro

Human telomerase contains evolutionarily conserved catalytic and structural subunits

Functional Multimerization of the Human Telomerase Reverse Transcriptase

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

Vaults and Telomerase Share a Common Subunit, TEP1

Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human Cancers

Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis

Telomere dysfunction: multiple paths to the same end

Telomere dysfunction: multiple paths to the same end

Abstract 2000: Biological function annotation of microarray data using correlated gene indices

Abstract A5: Tivozanib, a selective VEGFR TKI, potently blocks angiogenesis and growth in tumors that express a high level of VEGF-C and are refractory to VEGF-A blockade

Abstract 1727: Preclinical evaluation of pan-VEGFR inhibitor tivozanib in combination with capecitabine, sirolimus or erlotinib in genetically engineered tumor models support combinations based on complementary mechanisms

Population-based engineered tumor models as a platform for biomarker discovery in cancer

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