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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

Biochemistry (Easton), 1993-11, Vol.32 (45), p.11998-12006

1993

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Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity

The Journal of pharmacology and experimental therapeutics, 2005-01, Vol.312 (1), p.206-213

2005

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Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

Journal of clinical oncology, 2002-05, Vol.20 (9), p.2277

2002

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A Bifunctional DNA Repair Protein from Ferroplasma acidarmanus Exhibits O6-Alkylguanine- DNA Alkyltransferase and Endonuclease V Activities

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (10), p.3617-3622

2005

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2-Amino-O 4-benzylpteridine Derivatives: Potent Inactivators of O 6-Alkylguanine-DNA Alkyltransferase

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3887-3891

2004

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Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by Folate Esters of O 6-Benzyl-2‘-deoxyguanosine and of O 6-[4-(Hydroxymethyl)benzyl]guanine

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5193-5201

2007

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Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells

Chemical research in toxicology, 2002-02, Vol.15 (2), p.165

2002

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Differences in the Rate of Repair of O 6-Alkylguanines in Different Sequence Contexts by O 6-Alkylguanine-DNA Alkyltransferase

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1966-1971

2007

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Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5193

2007

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Mutagenesis by O 6-Methyl-, O 6-Ethyl-, and O 6-Benzylguanine and O 4-Methylthymine in Human Cells: Effects of O 6-Alkylguanine-DNA Alkyltransferase and Mismatch Repair

Chemical research in toxicology, 2001-07, Vol.14 (7), p.894-900

2001

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Mutagenesis by O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and Human Cells

Chemical research in toxicology, 2002-02, Vol.15 (2), p.165-169

2002

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β-Glucuronidase-Cleavable Prodrugs of O 6-Benzylguanine and O 6-Benzyl-2‘-deoxyguanosine

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.256-261

2005

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The Repair of the Tobacco Specific Nitrosamine Derived Adduct O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O 6-Alkylguanine-DNA Alkyltransferase Variants

Chemical research in toxicology, 2004-03, Vol.17 (3), p.424-434

2004

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Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Biochemical pharmacology, 2008-02, Vol.75 (3), p.618-626

2008

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Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase

Biochemistry (Easton), 2002-07, Vol.41 (27), p.8689

2002

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Role of GADD34 in modulation of cisplatin cytotoxicity

Biochemical pharmacology, 2006-01, Vol.71 (3), p.239-247

2006

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Repair of Oligodeoxyribonucleotides by O 6-Alkylguanine-DNA Alkyltransferase

Biochemistry (Easton), 2002-07, Vol.41 (27), p.8689-8697

2002

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Differences in the Rate of Repair of O6-Alkylguanines in Different Sequence Contexts by O6-Alkylguanine-DNA Alkyltransferase

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1966-1971

2007

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Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

Journal of clinical oncology, 2000-10, Vol.18 (20), p.3522-3528

2000

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β-Glucuronidase-Cleavable Prodrugs of O6-Benzylguanine and O6-Benzyl-2‘-deoxyguanosine

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.256-261

2005

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2-Amino-O4-benzylpteridine Derivatives: Potent Inactivators of O6-Alkylguanine-DNA Alkyltransferase

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3887-3891

2004

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Phase I Trial of Temozolomide Plus O 6 -Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

Journal of clinical oncology, 2005-10, Vol.23 (28), p.7178-7187

2005

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Effect of Ionic State of 2‘-Deoxyguanosine and Solvent on Its Aralkylation by Benzyl Bromide

Chemical research in toxicology, 1998-06, Vol.11 (6), p.696-702

1998

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Sensitization of Pancreatic Tumor Xenografts to Carmustine and Temozolomide by Inactivation of Their O6-Methylguanine-DNA Methyltransferase with O6-Benzylguanine or O6-Benzyl-2′-Deoxyguanosine

Clinical cancer research, 2003-09, Vol.9 (10), p.3801-3807

2003

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Debenzylation of O6-benzyl-8-oxoguanine in human liver: implications for O6-benzylguanine metabolism

Biochemical pharmacology, 2001-03, Vol.61 (6), p.721-726

2001

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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

A Bifunctional DNA Repair Protein from Ferroplasma acidarmanus Exhibits O6-Alkylguanine- DNA Alkyltransferase and Endonuclease V Activities

2-Amino-O 4-benzylpteridine Derivatives: Potent Inactivators of O 6-Alkylguanine-DNA Alkyltransferase

Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by Folate Esters of O 6-Benzyl-2‘-deoxyguanosine and of O 6-[4-(Hydroxymethyl)benzyl]guanine

Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells

Differences in the Rate of Repair of O 6-Alkylguanines in Different Sequence Contexts by O 6-Alkylguanine-DNA Alkyltransferase

Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine

Mutagenesis by O 6-Methyl-, O 6-Ethyl-, and O 6-Benzylguanine and O 4-Methylthymine in Human Cells: Effects of O 6-Alkylguanine-DNA Alkyltransferase and Mismatch Repair

Mutagenesis by O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and Human Cells

β-Glucuronidase-Cleavable Prodrugs of O 6-Benzylguanine and O 6-Benzyl-2‘-deoxyguanosine

The Repair of the Tobacco Specific Nitrosamine Derived Adduct O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O 6-Alkylguanine-DNA Alkyltransferase Variants

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase

Role of GADD34 in modulation of cisplatin cytotoxicity

Repair of Oligodeoxyribonucleotides by O 6-Alkylguanine-DNA Alkyltransferase

Differences in the Rate of Repair of O6-Alkylguanines in Different Sequence Contexts by O6-Alkylguanine-DNA Alkyltransferase

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

β-Glucuronidase-Cleavable Prodrugs of O6-Benzylguanine and O6-Benzyl-2‘-deoxyguanosine

2-Amino-O4-benzylpteridine Derivatives: Potent Inactivators of O6-Alkylguanine-DNA Alkyltransferase

Phase I Trial of Temozolomide Plus O 6 -Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

Effect of Ionic State of 2‘-Deoxyguanosine and Solvent on Its Aralkylation by Benzyl Bromide

Sensitization of Pancreatic Tumor Xenografts to Carmustine and Temozolomide by Inactivation of Their O6-Methylguanine-DNA Methyltransferase with O6-Benzylguanine or O6-Benzyl-2′-Deoxyguanosine

Debenzylation of O6-benzyl-8-oxoguanine in human liver: implications for O6-benzylguanine metabolism

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