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Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Retrovirology, 2018-08, Vol.15 (1), p.56-56, Article 56

2018

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Emergent drug resistance with integrase strand transfer inhibitor-based regimens

AIDS (London), 2017-06, Vol.31 (10), p.1425-1434

2017

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Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

The Journal of clinical investigation, 2009-03, Vol.119 (3), p.661-673

2009

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Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

The Lancet (British edition), 2010-05, Vol.375 (9729), p.1896-1905

2010

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Accumulation of Multiple Mutations In Vivo Confers Cross-Resistance to New and Existing Integrase Inhibitors

The Journal of infectious diseases, 2018-10, Vol.218 (11), p.1773-1776

2018

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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

Human gene therapy, 2008-10, Vol.19 (10), p.991

2008

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Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Science translational medicine, 2014-08, Vol.6 (250), p.250ra116

2014

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Stable expression of shRNAs in human CD34 + progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Nature biotechnology, 2006-05, Vol.24 (5), p.566-571

2006

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Prevalence of Human Immunodeficiency Virus-1 Integrase Strand Transfer Inhibitor Resistance in British Columbia, Canada Between 2009 and 2016: A Longitudinal Analysis

Open forum infectious diseases, 2019-03, Vol.6 (3), p.ofz060-ofz060

2019

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Molecular aspects of plant virus transmission by Olpidium and plasmodiophorid vectors

Annual review of phytopathology, 2004-01, Vol.42 (1), p.211-241

2004

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Sensing the danger in RNA

Nature medicine, 2005-03, Vol.11 (3), p.250-251

2005

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Nuclear Factor-κB Translocation Mediates Double-Stranded Ribonucleic Acid-Induced NIT-1 β-Cell Apoptosis and Up-Regulates Caspase-12 and Tumor Necrosis Factor Receptor-Associated Ligand (TRAIL)

Endocrinology (Philadelphia), 2003-10, Vol.144 (10), p.4616-4625

2003

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Evidence that Binding of Cucumber Necrosis Virus to Vector Zoospores Involves Recognition of Oligosaccharides

Journal of Virology, 2003-04, Vol.77 (7), p.3922-3928

2003

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Abstract 2829: Preclinical characterization of TKM-080301, a lipid nanoparticle formulation of a small interfering RNA directed against polo-like kinase 1

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2829-2829

2011

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2′-O-methyl-modified RNAs Act as TLR7 Antagonists

Molecular therapy, 2007-09, Vol.15 (9), p.1663-1669

2007

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A Phase 1b Study of IDH Inhibition with Enasidenib and MEK Inhibition with Cobimetinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring IDH2 and RAS Signaling Gene Mutations

Blood, 2022-11, Vol.140 (Supplement 1), p.11761-11762

2022

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Promising Safety and Efficacy Results from an Ongoing Phase 1b Study of Pembrolizumab Combined with Decitabine in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Blood, 2022-11, Vol.140 (Supplement 1), p.6235-6236

2022

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Protection Against Lethal Marburg Virus Infection Mediated by Lipid Encapsulated Small Interfering RNA

The Journal of infectious diseases, 2014-02, Vol.209 (4), p.562-570

2014

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Flotetuzumab as a salvage immunotherapy in advanced CD123-positive hematological malignancies, a phase 1 pilot study

Leukemia & lymphoma, 2024-04, p.1-9

2024

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siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease

The Journal of clinical investigation, 2017-12, Vol.127 (12), p.4437-4448

2017

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Poster: ALL-440: Promising Safety and Efficacy Results from an Ongoing Phase 1/2 Study of Pembrolizumab in Combination with Blinatumomab in Patients (pts) with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

Clinical lymphoma, myeloma and leukemia, 2021-09, Vol.21, p.S208-S208

2021

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ALL-440: Promising Safety and Efficacy Results from an Ongoing Phase 1/2 Study of Pembrolizumab in Combination with Blinatumomab in Patients (pts) with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

Clinical lymphoma, myeloma and leukemia, 2021-09, Vol.21, p.S276-S276

2021

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siRNA and innate immunity

Oligonucleotides, 2009-06, Vol.19 (2), p.89

2009

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Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

Nature microbiology, 2016-08, Vol.1 (10), p.16142

2016

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Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Emergent drug resistance with integrase strand transfer inhibitor-based regimens

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

Accumulation of Multiple Mutations In Vivo Confers Cross-Resistance to New and Existing Integrase Inhibitors

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Stable expression of shRNAs in human CD34 + progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Prevalence of Human Immunodeficiency Virus-1 Integrase Strand Transfer Inhibitor Resistance in British Columbia, Canada Between 2009 and 2016: A Longitudinal Analysis

Molecular aspects of plant virus transmission by Olpidium and plasmodiophorid vectors

Sensing the danger in RNA

Nuclear Factor-κB Translocation Mediates Double-Stranded Ribonucleic Acid-Induced NIT-1 β-Cell Apoptosis and Up-Regulates Caspase-12 and Tumor Necrosis Factor Receptor-Associated Ligand (TRAIL)

Evidence that Binding of Cucumber Necrosis Virus to Vector Zoospores Involves Recognition of Oligosaccharides

Abstract 2829: Preclinical characterization of TKM-080301, a lipid nanoparticle formulation of a small interfering RNA directed against polo-like kinase 1

2′-O-methyl-modified RNAs Act as TLR7 Antagonists

A Phase 1b Study of IDH Inhibition with Enasidenib and MEK Inhibition with Cobimetinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring IDH2 and RAS Signaling Gene Mutations

Promising Safety and Efficacy Results from an Ongoing Phase 1b Study of Pembrolizumab Combined with Decitabine in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Protection Against Lethal Marburg Virus Infection Mediated by Lipid Encapsulated Small Interfering RNA

Flotetuzumab as a salvage immunotherapy in advanced CD123-positive hematological malignancies, a phase 1 pilot study

Interim Results of a Phase 1/2 Study of Pembrolizumab Combined with Blinatumomab in Patients with Relapsed/Refractory (r/r) ALL

siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease

Poster: ALL-440: Promising Safety and Efficacy Results from an Ongoing Phase 1/2 Study of Pembrolizumab in Combination with Blinatumomab in Patients (pts) with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

ALL-440: Promising Safety and Efficacy Results from an Ongoing Phase 1/2 Study of Pembrolizumab in Combination with Blinatumomab in Patients (pts) with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

siRNA and innate immunity

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA

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