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Probing the structural dynamics of proteins and nucleic acids with optical tweezers

Current opinion in structural biology, 2015-10, Vol.34, p.43-51

2015

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Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

Nature communications, 2021-08, Vol.12 (1), p.4749-4749, Article 4749

2021

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Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

Journal of molecular biology, 2020-10, Vol.432 (21), p.5843-5847

2020

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Programmed −1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16167-16172

2012

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High-Precision Single-Molecule Characterization of the Folding of an HIV RNA Hairpin by Atomic Force Microscopy

Nano letters, 2018-10, Vol.18 (10), p.6318-6325

2018

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Conformational Shannon Entropy of mRNA Structures from Force Spectroscopy Measurements Predicts the Efficiency of -1 Programmed Ribosomal Frameshift Stimulation

Physical review letters, 2021-01, Vol.126 (3), p.038102-038102, Article 038102

2021

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Complex dynamics under tension in a high-efficiency frameshift stimulatory structure

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (39), p.19500-19505

2019

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Transition path times for nucleic Acid folding determined from energy-landscape analysis of single-molecule trajectories

Physical review letters, 2012-08, Vol.109 (6), p.068102-068102, Article 068102

2012

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Anti-frameshifting Ligand Reduces the Conformational Plasticity of the SARS Virus Pseudoknot

Journal of the American Chemical Society, 2014-02, Vol.136 (6), p.2196-2199

2014

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Conformational dynamics of the frameshift stimulatory structure in HIV-1

RNA (Cambridge), 2017-09, Vol.23 (9), p.1376-1384

2017

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Reconstructing folding energy landscape profiles from nonequilibrium pulling curves with an inverse Weierstrass integral transform

Physical review letters, 2014-12, Vol.113 (23), p.238104-238104, Article 238104

2014

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A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

Nature structural & molecular biology, 2013-06, Vol.20 (6), p.728-734

2013

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

Nature structural & molecular biology, 2008-11, Vol.15 (11), p.1199-1205

2008

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Pre-mRNA splicing: a complex picture in higher definition

Trends in biochemical sciences (Amsterdam. Regular ed.), 2008-06, Vol.33 (6), p.243-246

2008

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Spliceosome structure: Piece by piece

Biochimica et biophysica acta, 2009-09, Vol.1789 (9), p.624-633

2009

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Crystal Structure of a Core Spliceosomal Protein Interface

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (5), p.1266-1271

2006

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Characterization of a U2AF-Independent Commitment Complex (E′) in the Mammalian Spliceosome Assembly Pathway

Molecular and Cellular Biology, 2005-01, Vol.25 (1), p.233-240

2005

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Context-Dependent Remodeling of Structure in Two Large Protein Fragments

Journal of molecular biology, 2010-10, Vol.402 (4), p.720-730

2010

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Strand Threading in Subgenomic Flavivirus RNAs Generates Exoribonuclease-Resistance Mechanically

Biophysical journal, 2020-02, Vol.118 (3), p.333a-334a

2020

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Force Spectroscopy of the Frameshift Signal from West Nile Virus Reveals Multiple Folding Pathways and Structural Heterogeneity

Biophysical journal, 2019-02, Vol.116 (3), p.361a-361a

2019

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Anti-Frameshifting Ligand Active against SARS Coronavirus-2 is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

Biophysical journal, 2021-02, Vol.120 (3), p.287a-287a

2021

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Structural Dynamics of SARS-CoV-2 Frameshift Signal Studied by Single-Molecule Force Spectroscopy Reveal Topologically Distinct Conformers

Biophysical journal, 2021-02, Vol.120 (3), p.314a-314a

2021

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Folding Heterogeneity in HIV-1 Frameshifting Hairpin

Biophysical journal, 2017-02, Vol.112 (3), p.368a-368a

2017

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Programmed -1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (4), p.16167

2012

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Frameshifting Efficiency is not Determined by the Mechanical Stability of RNA Pseudoknots

Biophysical journal, 2012-01, Vol.102 (3), p.646a-646a

2012

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Probing the structural dynamics of proteins and nucleic acids with optical tweezers

Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

Programmed −1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

High-Precision Single-Molecule Characterization of the Folding of an HIV RNA Hairpin by Atomic Force Microscopy

Conformational Shannon Entropy of mRNA Structures from Force Spectroscopy Measurements Predicts the Efficiency of -1 Programmed Ribosomal Frameshift Stimulation

Complex dynamics under tension in a high-efficiency frameshift stimulatory structure

Transition path times for nucleic Acid folding determined from energy-landscape analysis of single-molecule trajectories

Anti-frameshifting Ligand Reduces the Conformational Plasticity of the SARS Virus Pseudoknot

Conformational dynamics of the frameshift stimulatory structure in HIV-1

Reconstructing folding energy landscape profiles from nonequilibrium pulling curves with an inverse Weierstrass integral transform

A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

Pre-mRNA splicing: a complex picture in higher definition

Spliceosome structure: Piece by piece

Crystal Structure of a Core Spliceosomal Protein Interface

Characterization of a U2AF-Independent Commitment Complex (E′) in the Mammalian Spliceosome Assembly Pathway

Context-Dependent Remodeling of Structure in Two Large Protein Fragments

Strand Threading in Subgenomic Flavivirus RNAs Generates Exoribonuclease-Resistance Mechanically

Force Spectroscopy of the Frameshift Signal from West Nile Virus Reveals Multiple Folding Pathways and Structural Heterogeneity

Anti-Frameshifting Ligand Active against SARS Coronavirus-2 is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

Structural Dynamics of SARS-CoV-2 Frameshift Signal Studied by Single-Molecule Force Spectroscopy Reveal Topologically Distinct Conformers

Folding Heterogeneity in HIV-1 Frameshifting Hairpin

Programmed -1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

Frameshifting Efficiency is not Determined by the Mechanical Stability of RNA Pseudoknots

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