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Targeting the β secretase BACE1 for Alzheimer's disease therapy

Lancet neurology, 2014-03, Vol.13 (3), p.319-329

2014

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BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

The Journal of experimental medicine, 2018-03, Vol.215 (3), p.927-940

2018

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Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

eLife, 2017-06, Vol.6

2017

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Role of BACE1 in Alzheimer's synaptic function

Translational neurodegeneration, 2017-08, Vol.6 (1), p.23-23, Article 23

2017

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Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains

Molecular psychiatry, 2019-09, Vol.24 (9), p.1369-1382

2019

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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease

Nature reviews. Neurology, 2021-11, Vol.17 (11), p.703-714

2021

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Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells

PloS one, 2016-09, Vol.11 (9), p.e0163072-e0163072

2016

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BACE1 controls synaptic function through modulating release of synaptic vesicles

Molecular psychiatry, 2021-11, Vol.26 (11), p.6394-6410

2021

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Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz

Scientific reports, 2024-10, Vol.14 (1), p.23365-15, Article 23365

2024

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Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Molecular neurodegeneration, 2020-11, Vol.15 (1), p.69-4, Article 69

2020

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Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China

PloS one, 2015-12, Vol.10 (12), p.e0144898-e0144898

2015

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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains

Molecular neurodegeneration, 2021-07, Vol.16 (1), p.45-45, Article 45

2021

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Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer's disease

Translational neurodegeneration, 2024-07, Vol.13 (1), p.38-4, Article 38

2024

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A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

CNS drugs, 2019-03, Vol.33 (3), p.251-263

2019

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Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

Biological psychiatry (1969), 2014-07, Vol.76 (2), p.120-127

2014

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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains

Scientific reports, 2017-07, Vol.7 (1), p.6145-9, Article 6145

2017

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Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

International journal of molecular sciences, 2023-01, Vol.24 (2), p.1206

2023

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Molecular neurodegeneration, 2023-05, Vol.18 (1), p.31-31, Article 31

2023

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Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

Frontiers in molecular neuroscience, 2017-04, Vol.10, p.97-97

Yan, Riqiang

2017

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Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques

Alzheimer's & dementia, 2023-12, Vol.19 (S24), p.n/a

Yan, Riqiang

2023

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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

The Journal of cell biology, 2011-11, Vol.195 (5), p.765-779

2011

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Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration

Neural regeneration research, 2023-12, Vol.18 (12), p.2667-2668

2023

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High glucose promotes Aβ production by inhibiting APP degradation

PloS one, 2013-07, Vol.8 (7), p.e69824-e69824

2013

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Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

PloS one, 2014-12, Vol.9 (12), p.e114521

2014

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

Translational neurodegeneration, 2016-07, Vol.5 (1), p.13-13, Article 13

Yan, Riqiang

2016

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

Role of BACE1 in Alzheimer's synaptic function

Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease

Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells

BACE1 controls synaptic function through modulating release of synaptic vesicles

Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz

Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains

Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer's disease

A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration

High glucose promotes Aβ production by inhibiting APP degradation

Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

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