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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10147-10162

2016

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Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution

Nucleic acids research, 2010-06, Vol.38 (11), p.3834-3847

2010

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Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (5), p.E906-E915

2018

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Mapping the Landscape of RNA Dynamics with NMR Spectroscopy

Accounts of chemical research, 2011-12, Vol.44 (12), p.1292-1301

2011

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Translation on demand by a simple RNA-based thermosensor

Nucleic acids research, 2011-04, Vol.39 (7), p.2855-2868

2011

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Quantitative 2D and 3D Γ-HCP Experiments for the Determination of the Angles α and ζ in the Phosphodiester Backbone of Oligonucleotides

Journal of the American Chemical Society, 2010-08, Vol.132 (30), p.10318-10329

2010

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Modulation of the stability of the Salmonella fourU-type RNA thermometer

Nucleic acids research, 2011-10, Vol.39 (18), p.8258-8270

2011

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Mechanistic insights into temperature-dependent regulation of the simple cyanobacterial hsp17 RNA thermometer at base-pair resolution

Nucleic acids research, 2015-06, Vol.43 (11), p.5572-5585

2015

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NMR-Spektroskopie zum Verständnis RNA-basierter Regulation

Biospektrum, 2011-03, Vol.17 (2), p.174-177

2011

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Drugging an undruggable pocket on KRAS

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (32), p.15823-15829

2019

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BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

Neuro-oncology (Charlottesville, Va.), 2023-05, Vol.25 (5), p.913-926

2023

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Abstract 3084: BI-907828: A novel, potent MDM2 inhibitor, inhibits GBM brain tumor stem cells in vitro and prolonged survival in orthotopic xenograft mouse models

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3084-3084

2019

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Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2–p53 Antagonist Suitable for Intermittent Dose Schedules

Molecular cancer therapeutics, 2024-09, p.OF1-OF14

2024

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RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis

Journal of biomolecular NMR, 2009-09, Vol.45 (1-2), p.143-155

2009

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Individual Basepair Stability of DNA and RNA Studied by NMR-Detected Solvent Exchange

Biophysical journal, 2012-06, Vol.102 (11), p.2564-2574

2012

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The world is flat

Nature chemical biology, 2010-05, Vol.6 (5), p.312-313

2010

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REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (7), p.3365-3367

2020

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Abstract 3197: BI-907828, a novel and potent MDM2-p53 antagonist, acts synergistically in a triple combination with anti-PD-1 and anti-LAG-3 antibodies in syngeneic mouse models of cancer

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3197-3197

2019

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Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.DDT01-01-DDT01-01

2019

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HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of ¹³C-, ¹⁵N-labeled RNA oligonucleotides

Journal of biomolecular NMR, 2009-06, Vol.44 (2), p.101-105

2009

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A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetic processes

Journal of magnetic resonance (1997), 2015-02, Vol.251, p.84-93

2015

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Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1271-1271

2021

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Abstract 4868: BI 907828: A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedules

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4868-4868

2018

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Thermodynamics: the world is flat

Nature chemical biology, 2010-05, Vol.6 (5), p.312

2010

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Abstract 4866: BI 907828: A novel, potent MDM2 inhibitor that induces antitumor immunologic memory and acts synergistically with an anti-PD-1 antibody in syngeneic mouse models of cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4866-4866

2018

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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution

Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome

Mapping the Landscape of RNA Dynamics with NMR Spectroscopy

Translation on demand by a simple RNA-based thermosensor

Quantitative 2D and 3D Γ-HCP Experiments for the Determination of the Angles α and ζ in the Phosphodiester Backbone of Oligonucleotides

Modulation of the stability of the Salmonella fourU-type RNA thermometer

Mechanistic insights into temperature-dependent regulation of the simple cyanobacterial hsp17 RNA thermometer at base-pair resolution

NMR-Spektroskopie zum Verständnis RNA-basierter Regulation

Drugging an undruggable pocket on KRAS

BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

Abstract 3084: BI-907828: A novel, potent MDM2 inhibitor, inhibits GBM brain tumor stem cells in vitro and prolonged survival in orthotopic xenograft mouse models

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2–p53 Antagonist Suitable for Intermittent Dose Schedules

RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis

Individual Basepair Stability of DNA and RNA Studied by NMR-Detected Solvent Exchange

The world is flat

REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers

Abstract 3197: BI-907828, a novel and potent MDM2-p53 antagonist, acts synergistically in a triple combination with anti-PD-1 and anti-LAG-3 antibodies in syngeneic mouse models of cancer

Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape

HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of ¹³C-, ¹⁵N-labeled RNA oligonucleotides

A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetic processes

Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor

Abstract 4868: BI 907828: A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedules

Thermodynamics: the world is flat

Abstract 4866: BI 907828: A novel, potent MDM2 inhibitor that induces antitumor immunologic memory and acts synergistically with an anti-PD-1 antibody in syngeneic mouse models of cancer

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