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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4090-4110

2011

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4127-4157

2011

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Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

Drug metabolism and disposition, 2002-08, Vol.30 (8), p.883

2002

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The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.762

2003

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4111-4126

2011

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Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Drug metabolism and disposition, 2015-12, Vol.43 (12), p.1917-1928

2015

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Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1266

2002

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Identification of the human cytochromes P450 responsible for atomoxetine metabolism

Drug metabolism and disposition, 2002-03, Vol.30 (3), p.319

2002

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Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations

Pharmaceutical research, 2006-04, Vol.23 (4), p.654-662

2006

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4074-4089

2011

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Clinical pharmacokinetics of atomoxetine

Clinical pharmacokinetics, 2005-01, Vol.44 (6), p.571-590

2005

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Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase

Drug metabolism and disposition, 2013-03, Vol.41 (3), p.541

2013

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PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4050-4073

2011

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Effect of Tadalafil on Cytochrome P450 3A4-mediated Clearance: Studies in Vitro and in Vivo

Clinical pharmacology and therapeutics, 2005-01, Vol.77 (1), p.63-75

2005

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The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.957

2002

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Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors

The Journal of pharmacology and experimental therapeutics, 1999-07, Vol.290 (1), p.429

1999

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Further characterization of the expression in liver and catalytic activity of CYP2B6

The Journal of pharmacology and experimental therapeutics, 1998-09, Vol.286 (3), p.1253

1998

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The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies

Toxicologic pathology, 1995-03, Vol.23 (2), p.199-208

1995

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Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine

The Journal of pharmacology and experimental therapeutics, 2001-06, Vol.297 (3), p.1044

2001

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Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6

The Journal of pharmacology and experimental therapeutics, 1999-01, Vol.288 (1), p.21

1999

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A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

Journal of pharmacological and toxicological methods, 2001-09, Vol.46 (2), p.117-123

2001

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Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices

Drug metabolism and disposition, 1998-11, Vol.26 (11), p.1063

1998

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Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.994

2000

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Present and future in vitro approaches for drug metabolism

Journal of pharmacological and toxicological methods, 2000-07, Vol.44 (1), p.313-324

2000

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Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine

The Journal of pharmacology and experimental therapeutics, 1996-02, Vol.276 (2), p.658

1996

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists

Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes

Identification of the human cytochromes P450 responsible for atomoxetine metabolism

Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

Clinical pharmacokinetics of atomoxetine

Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase

PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

Effect of Tadalafil on Cytochrome P450 3A4-mediated Clearance: Studies in Vitro and in Vivo

The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450

Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors

Further characterization of the expression in liver and catalytic activity of CYP2B6

The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies

Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine

Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6

A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices

Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors

Present and future in vitro approaches for drug metabolism

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine

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