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N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator

Molecular pharmacology, 2008-03, Vol.73 (3), p.977-986

2008

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In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.818

2008

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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Pharmacology research & perspectives, 2019-02, Vol.7 (1), p.e00467-n/a

2019

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Effect of Linking Bridge Modifications on the Antipsychotic Profile of Some Phthalimide and Isoindolinone Derivatives

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.149-157

1996

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Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia

Blood, 2008-04, Vol.111 (8), p.3991-3997

2008

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N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy

ACS medicinal chemistry letters, 2011-06, Vol.2 (6), p.481-484

2011

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A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86

The Journal of pharmacology and experimental therapeutics, 1993-11, Vol.267 (2), p.852

1993

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Kv7 potassium channel activation with ICA‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy

Epilepsia (Copenhagen), 2013-08, Vol.54 (8), p.1437-1443

2013

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Novel Inhibitors of the Gardos Channel for the Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.976-982

2008

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Synthesis and Evaluation of Heterocyclic Carboxamides as Potential Antipsychotic Agents

Journal of medicinal chemistry, 1996-11, Vol.39 (24), p.4692-4703

1996

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Cyclic Benzamides as Mixed Dopamine D2/Serotonin 5-HT2 Receptor Antagonists: Potential Atypical Antipsychotic Agents

Journal of medicinal chemistry, 1994-08, Vol.37 (16), p.2552-2563

1994

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Anti‐haemolytic effect of senicapoc and decrease in NT‐proBNP in adults with sickle cell anaemia

British journal of haematology, 2011-12, Vol.155 (5), p.634-636

2011

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Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains

Psychopharmacology, 1990-11, Vol.102 (3), p.419-421

Rigdon, G C

1990

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Multistate outbreak of Salmonella Poona infections associated with imported cucumbers, 2015-2016

Epidemiology and infection, 2019-09, Vol.147, p.e270, Article e270

2019

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Structure−Activity Relationships of a Series of Substituted Benzamides: Potent D2/5-HT2 Antagonists and 5-HT1a Agonists as Neuroleptic Agents

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1172-1188

1996

Volltextzugriff (PDF)

Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity

Journal of medicinal chemistry, 2003-01, Vol.46 (3), p.409-416

2003

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Indanylidenes. 1. Design and Synthesis of (E)-2-(4,6-Difluoro-1-indanylidene)acetamide, a Potent, Centrally Acting Muscle Relaxant with Antiinflammatory and Analgesic Activity

Journal of medicinal chemistry, 2003-01, Vol.46 (3), p.399-408

2003

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Design of Experiments for Reliability Achievement

1st edition, 2022

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1192U90 in animal tests that predict antipsychotic efficacy, anxiolysis, and extrapyramidal side effects

Neuropsychopharmacology (New York, N.Y.), 1996-09, Vol.15 (3), p.231-242

1996

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KCNQ potassium channels: drug targets for the treatment of epilepsy and pain

Expert opinion on therapeutic patents, 2004-04, Vol.14 (4), p.457-469

2004

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Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex

The Journal of neuroscience, 1986-09, Vol.6 (9), p.2535-2542

1986

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Prepulse inhibition as a screening test for potential antipsychotics

Drug development research, 1991, Vol.23 (1), p.91-99

1991

Volltextzugriff (PDF)

A Method for Point-of-Production Attribution of Salmonellosis Cases in the U.S

American journal of epidemiology, 2006-06, Vol.163 (suppl_11), p.S201-S201

2006

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K v7 potassium channel activation with ICA ‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy

Epilepsia (Copenhagen), 2013-08, Vol.54 (8), p.1437-1443

2013

Volltextzugriff (PDF)

Urethane affects the rat visual system at subanesthetic doses

Physiology & behavior, 1987, Vol.41 (4), p.327-330

1987

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N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator

In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Effect of Linking Bridge Modifications on the Antipsychotic Profile of Some Phthalimide and Isoindolinone Derivatives

Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy

A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86

Kv7 potassium channel activation with ICA‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy

Novel Inhibitors of the Gardos Channel for the Treatment of Sickle Cell Disease

Synthesis and Evaluation of Heterocyclic Carboxamides as Potential Antipsychotic Agents

Cyclic Benzamides as Mixed Dopamine D2/Serotonin 5-HT2 Receptor Antagonists: Potential Atypical Antipsychotic Agents

Anti‐haemolytic effect of senicapoc and decrease in NT‐proBNP in adults with sickle cell anaemia

Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains

Multistate outbreak of Salmonella Poona infections associated with imported cucumbers, 2015-2016

Structure−Activity Relationships of a Series of Substituted Benzamides: Potent D2/5-HT2 Antagonists and 5-HT1a Agonists as Neuroleptic Agents

Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity

Indanylidenes. 1. Design and Synthesis of (E)-2-(4,6-Difluoro-1-indanylidene)acetamide, a Potent, Centrally Acting Muscle Relaxant with Antiinflammatory and Analgesic Activity

Design of Experiments for Reliability Achievement

1192U90 in animal tests that predict antipsychotic efficacy, anxiolysis, and extrapyramidal side effects

KCNQ potassium channels: drug targets for the treatment of epilepsy and pain

Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex

Prepulse inhibition as a screening test for potential antipsychotics

A Method for Point-of-Production Attribution of Salmonellosis Cases in the U.S

K v7 potassium channel activation with ICA ‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy

Urethane affects the rat visual system at subanesthetic doses

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