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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Cancer research (Chicago, Ill.), 2018-03, Vol.78 (6), p.1537-1548

2018

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Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4163-4168

2006

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Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1730-1743

2006

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Synthesis and antibacterial activity of C12 des-methyl ketolides

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4692-4696

2006

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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2013-2027

2020

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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7773-7816

2020

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Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9360-9370

2018

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Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14885-14904

2020

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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.4869-4881

2017

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Antihydrophobic Solvent Effects: An Experimental Probe for the Hydrophobic Contribution to Enzyme−Inhibitor Binding

Journal of the American Chemical Society, 2002-04, Vol.124 (15), p.3853-3857

2002

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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.DDT01-04-DDT01-04

2018

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Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.330-330

2016

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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.330-330

2016

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Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.9124-9129

2014

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Synthesis and Antibacterial Activity of Novel C 12 Vinyl Ketolides

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1730-1743

2006

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Synthesis and antibacterial activity of C 12 des-methyl ketolides

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4692-4696

2006

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Synthesis and antibacterial activity of C sub(12) des-methyl ketolides

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4692-4696

2006

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Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation

PloS one, 2017-05, Vol.12 (5), p.e0176787

2017

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Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

The New England journal of medicine, 2021-10, Vol.385 (17), p.1559-1569

2021

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Effects of exercise mode in knee cartilage thickness

Journal of bodywork and movement therapies, 2020-10, Vol.24 (4), p.490-495

2020

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Comparison of Paper-and-Pencil Versus Tablet Administration of the 2021 National Youth Risk Behavior Survey (YRBS)

Journal of adolescent health, 2024-04, Vol.74 (4), p.814-819

2024

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Comparison of linea alba length and core-muscles engagement during core and lower back orientated exercises

Journal of bodywork and movement therapies, 2021-10, Vol.28, p.131-137

2021

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Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2

Emerging microbes & infections, 2022-12, Vol.11 (1), p.1037-1048

2022

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Changes in Illicit Drug Use Among High School Students in Southeastern U.S. States—2009 to 2019

Journal of prevention (2022 : Print), 2024-10, Vol.45 (5), p.815-831

2024

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Vegetable hierarchical structures as template for bone regeneration: New bio‐ceramization process for the development of a bone scaffold applied to an experimental sheep model

Journal of biomedical materials research. Part B, Applied biomaterials, 2020-04, Vol.108 (3), p.600-611

2020

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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides

Synthesis and antibacterial activity of C12 des-methyl ketolides

Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases

Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

Antihydrophobic Solvent Effects: An Experimental Probe for the Hydrophobic Contribution to Enzyme−Inhibitor Binding

Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Synthesis and Antibacterial Activity of Novel C 12 Vinyl Ketolides

Synthesis and antibacterial activity of C 12 des-methyl ketolides

Synthesis and antibacterial activity of C sub(12) des-methyl ketolides

Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation

Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

Effects of exercise mode in knee cartilage thickness

Comparison of Paper-and-Pencil Versus Tablet Administration of the 2021 National Youth Risk Behavior Survey (YRBS)

Comparison of linea alba length and core-muscles engagement during core and lower back orientated exercises

Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2

Changes in Illicit Drug Use Among High School Students in Southeastern U.S. States—2009 to 2019

Vegetable hierarchical structures as template for bone regeneration: New bio‐ceramization process for the development of a bone scaffold applied to an experimental sheep model

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