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Complement in immune and inflammatory disorders: pathophysiological mechanisms

The Journal of immunology (1950), 2013-04, Vol.190 (8), p.3831-3838

2013

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Clinical promise of next-generation complement therapeutics

Nature reviews. Drug discovery, 2019-09, Vol.18 (9), p.707-729

2019

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Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy

Immunobiology (1979), 2012-11, Vol.217 (11), p.1057-1066

Ricklin, Daniel

2012

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Complement in immune and inflammatory disorders: therapeutic interventions

The Journal of immunology (1950), 2013-04, Vol.190 (8), p.3839-3847

2013

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Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense

Immunological reviews, 2016-11, Vol.274 (1), p.33-58

2016

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Protection of host cells by complement regulators

Immunological reviews, 2016-11, Vol.274 (1), p.152-171

2016

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Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (41), p.10948-10953

2017

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The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology

Frontiers in immunology, 2021-04, Vol.12, p.662164-662164

2021

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Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Blood, 2017-02, Vol.129 (8), p.970-980

2017

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Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Nature structural & molecular biology, 2017-08, Vol.24 (8), p.643

2017

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Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

European journal of clinical investigation, 2015-04, Vol.45 (4), p.423-440

2015

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Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

Advanced drug delivery reviews, 2011-09, Vol.63 (12), p.1042-1050

2011

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Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Blood, 2014-03, Vol.123 (13), p.2094-2101

2014

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Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

The Journal of immunology (1950), 2014-06, Vol.192 (12), p.6020-6027

2014

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Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Nature communications, 2022-09, Vol.13 (1), p.5519-5519, Article 5519

2022

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Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode

The EMBO journal, 2016-05, Vol.35 (10), p.1133-1149

2016

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Complement deficiency promotes cutaneous wound healing in mice

The Journal of immunology (1950), 2015-02, Vol.194 (3), p.1285-1291

2015

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Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

Haematologica (Roma), 2020-02, Vol.105 (2), p.e57

2020

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Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Nature immunology, 2009-07, Vol.10 (7), p.721-727

2009

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Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

Journal of clinical periodontology, 2016-03, Vol.43 (3), p.238-249

2016

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Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine

The Journal of immunology (1950), 2011-04, Vol.186 (7), p.4269-4277

2011

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Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Frontiers in immunology, 2023-09, Vol.14, p.1226832-1226832

2023

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Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

The Journal of immunology (1950), 2016-06, Vol.196 (11), p.4671-4680

2016

Volltextzugriff (PDF)

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation

The Journal of immunology (1950), 2016-01, Vol.196 (2), p.866-876

2016

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Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

Immunobiology (1979), 2015-04, Vol.220 (4), p.476-482

2015

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Complement
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Complement Activation
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Allergy And Immunology
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Complement Activation - Drug Effects
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Proteins
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Complement System Proteins - Physiology
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Complement System Proteins - Immunology
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Compstatin
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Inflammation
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Complement in immune and inflammatory disorders: pathophysiological mechanisms

Clinical promise of next-generation complement therapeutics

Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy

Complement in immune and inflammatory disorders: therapeutic interventions

Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense

Protection of host cells by complement regulators

Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4

The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode

Complement deficiency promotes cutaneous wound healing in mice

Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation

Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

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