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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Toxicological sciences, 2018-04, Vol.162 (2), p.655-666

2018

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Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells

Cancer cell international, 2018-03, Vol.18 (1), p.46-46, Article 46

2018

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The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells

PloS one, 2014-09, Vol.9 (9), p.e107842

2014

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Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13246

2023

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Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

Toxicology in vitro, 2019-10, Vol.60, p.212-228

2019

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Toxicological sciences, 2015-10, Vol.147 (2), p.412-424

2015

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Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

Toxicology letters, 2018-10, Vol.295, p.187-194

2018

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Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis

Regulatory toxicology and pharmacology, 2020-11, Vol.117, p.104758, Article 104758

2020

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Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

Cells (Basel, Switzerland), 2020-04, Vol.9 (4), p.964

2020

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Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

Journal of pharmacological and toxicological methods, 2015-05, Vol.73, p.63-71

2015

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Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

FEBS open bio, 2022-05, Vol.12 (5), p.937-958

2022

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Time course of gene expression profiling in the liver of experimental mice infected with Echinococcus multilocularis

PloS one, 2011-01, Vol.6 (1), p.e14557-e14557

2011

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In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

Toxicology in vitro, 2015-12, Vol.30 (1), p.36-51

2015

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Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

Toxicology in vitro, 2016-06, Vol.33, p.71-79

2016

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Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Toxicology in vitro, 2015-12, Vol.30 (1), p.19-26

2015

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Prediction of drug induced liver injury using molecular and biological descriptors

Combinatorial chemistry & high throughput screening, 2015-01, Vol.18 (3), p.315

2015

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Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study

Bioinformatics and biology insights, 2020, Vol.14, p.117793222095274-1177932220952742

2020

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Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.870

2006

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Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures

Chemico-biological interactions, 2009-05, Vol.179 (2), p.247-255

2009

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Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

Toxicology in vitro, 2015-12, Vol.30 (1), p.52-61

2015

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Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

Toxicology and applied pharmacology, 2014-01, Vol.274 (1), p.124-136

2014

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The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation

International journal of hepatology (New York), 2012-01, Vol.2012, p.140147-11

2012

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Increased Survival despite Failure of Transplanted Human Hepatocyte Implantation into Liver Parenchyma of Nude Mice with Repeated Lethal Jo2-Induced Liver Deficiency

Cell transplantation, 2014-01, Vol.23 (12), p.1557-1572

2014

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Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode

World journal of gastroenterology : WJG, 2009-05, Vol.15 (17), p.2116-2124

2009

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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells

The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells

Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells

Time course of gene expression profiling in the liver of experimental mice infected with Echinococcus multilocularis

In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Prediction of drug induced liver injury using molecular and biological descriptors

Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study

Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating

Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures

Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation

Increased Survival despite Failure of Transplanted Human Hepatocyte Implantation into Liver Parenchyma of Nude Mice with Repeated Lethal Jo2-Induced Liver Deficiency

Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode

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