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Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti‐tumour efficacy

British journal of pharmacology, 2012-01, Vol.165 (1), p.148-166

2012

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Iron chelators for the treatment of cancer

Current medicinal chemistry, 2012, Vol.19 (17), p.2689-2702

2012

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Glucose modulation induces reactive oxygen species and increases P‐glycoprotein‐mediated multidrug resistance to chemotherapeutics

British journal of pharmacology, 2015-05, Vol.172 (10), p.2557-2572

2015

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Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo

British journal of pharmacology, 2013-03, Vol.168 (6), p.1316-1328

2013

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Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

British journal of cancer, 2013-02, Vol.108 (2), p.409-419

2013

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Molecular Pharmacology of the Interaction of Anthracyclines with Iron

Molecular pharmacology, 2005-08, Vol.68 (2), p.261-271

2005

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Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia

Future medicinal chemistry, 2022-07, Vol.14 (13), p.1005-1017

2022

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Theoretical modeling of single-laser-shot, chirped-probe-pulse femtosecond coherent anti-Stokes Raman scattering thermometry

Applied physics. B, Lasers and optics, 2011-09, Vol.104 (3), p.699-714

2011

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Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal–epithelial transition in breast cancer cells

Oncogene, 2013-03, Vol.32 (10), p.1240-1251

2013

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Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution and Trafficking

Molecular pharmacology, 2008-03, Vol.73 (3), p.833-844

2008

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Iron chelators as therapeutic agents for the treatment of cancer

Critical reviews in oncology/hematology, 2002-06, Vol.42 (3), p.267-281

Richardson, D.R.

2002

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Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Biochimica et biophysica acta, 2015-05, Vol.1853 (5), p.1130-1144

2015

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Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies

Redox biology, 2021-05, Vol.41, p.101896-101896, Article 101896

2021

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Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6138-6141

2007

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Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class

Molecular pharmacology, 2008-07, Vol.74 (1), p.225-235

2008

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The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis

Biochimica et biophysica acta. Molecular basis of disease, 2020-12, Vol.1866 (12), p.165970, Article 165970

2020

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The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1

Carcinogenesis (New York), 2003-10, Vol.24 (10), p.1601-1614

2003

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Examination of the Mechanism(s) Involved in Doxorubicin-Mediated Iron Accumulation in Ferritin: Studies Using Metabolic Inhibitors, Protein Synthesis Inhibitors, and Lysosomotropic Agents

Molecular pharmacology, 2004-01, Vol.65 (1), p.181-195

2004

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The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents

Blood, 1995-12, Vol.86 (11), p.4295-4306

1995

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The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis

Carcinogenesis (New York), 2006-11, Vol.27 (11), p.2157-2169

2006

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone

Blood, 1997-04, Vol.89 (8), p.3025-3038

1997

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Antioxidant defense mechanisms and its dysfunctional regulation in the mitochondrial disease, Friedreich's ataxia

Free radical biology & medicine, 2020-11, Vol.159, p.177-188

2020

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Treatment of dilated cardiomyopathy in a mouse model of Friedreich’s ataxia using N-acetylcysteine and identification of alterations in microRNA expression that could be involved in its pathogenesis

Pharmacological research, 2020-09, Vol.159, p.104994-104994, Article 104994

2020

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Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

Biochimica et biophysica acta, 2009-07, Vol.1790 (7), p.702-717

2009

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Anthracyclines Induce Accumulation of Iron in Ferritin in Myocardial and Neoplastic Cells: Inhibition of the Ferritin Iron Mobilization Pathway

Molecular pharmacology, 2003-04, Vol.63 (4), p.849-861

2003

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Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti‐tumour efficacy

Iron chelators for the treatment of cancer

Glucose modulation induces reactive oxygen species and increases P‐glycoprotein‐mediated multidrug resistance to chemotherapeutics

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

Molecular Pharmacology of the Interaction of Anthracyclines with Iron

Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia

Theoretical modeling of single-laser-shot, chirped-probe-pulse femtosecond coherent anti-Stokes Raman scattering thermometry

Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal–epithelial transition in breast cancer cells

Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution and Trafficking

Iron chelators as therapeutic agents for the treatment of cancer

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class

The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis

The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1

Examination of the Mechanism(s) Involved in Doxorubicin-Mediated Iron Accumulation in Ferritin: Studies Using Metabolic Inhibitors, Protein Synthesis Inhibitors, and Lysosomotropic Agents

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents

The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: The mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone

Antioxidant defense mechanisms and its dysfunctional regulation in the mitochondrial disease, Friedreich's ataxia

Treatment of dilated cardiomyopathy in a mouse model of Friedreich’s ataxia using N-acetylcysteine and identification of alterations in microRNA expression that could be involved in its pathogenesis

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

Anthracyclines Induce Accumulation of Iron in Ferritin in Myocardial and Neoplastic Cells: Inhibition of the Ferritin Iron Mobilization Pathway

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