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Insulin detemir is a fully efficacious, low affinity agonist at the insulin receptor

Diabetes, obesity & metabolism, 2010-08, Vol.12 (8), p.665-673

2010

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Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo

Biochemical journal, 1995-12, Vol.312 ( Pt 3) (3), p.725-731

1995

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Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

Diabetologia, 1996-03, Vol.39 (3), p.281-288

1996

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The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin

Pharmaceutical research, 2004-08, Vol.21 (8), p.1498-1504

2004

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Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs

American journal of physiology: endocrinology and metabolism, 2005-02, Vol.288 (2), p.E412-E421

2005

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Action profile of cobalt(III)-insulin. A novel principle of protraction of potential use for basal insulin delivery

Diabetes (New York, N.Y.), 1995-12, Vol.44 (12), p.1381-1385

1995

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Enhanced Insulin Secretion and Improved Glucose Tolerance in Mice Lacking CD26

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (12), p.6874-6879

2000

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Hypothalamic CART is a new anorectic peptide regulated by leptin

Nature (London), 1998-05, Vol.393 (6680), p.72-76

1998

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GLP‐1 derivative liraglutide in rats with β‐cell deficiencies: influence of metabolic state on β‐cell mass dynamics

British journal of pharmacology, 2003-09, Vol.140 (1), p.123-132

2003

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Monomeric insulins obtained by protein engineering and their medical implications

Nature (London), 1988-06, Vol.333 (6174), p.679-682

1988

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Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives

Pharmaceutical research, 2006, Vol.23 (1), p.49-55

2006

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Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4435-4439

2003

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In Vitro and In Vivo Potency of Insulin Analogues Designed for Clinical Use

Diabetic medicine, 1991-11, Vol.8 (9), p.839-847

1991

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Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV

European journal of pharmacology, 2005-02, Vol.509 (2), p.211-217

2005

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Chamber-Dependent Expression of Brain Natriuretic Peptide and Its mRNA in Normal and Diabetic Pig Heart

Hypertension (Dallas, Tex. 1979), 2002-07, Vol.40 (1), p.54-60

2002

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Kernel Function Smoothing of Insulin Absorption Kinetics

Biometrics, 1989-12, Vol.45 (4), p.1041-1052

1989

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Action profile of cobalt(III)-insulin. A novel principle of protraction of potential use for basal insulin delivery

Diabetes (New York, N.Y.), 1995-12, Vol.44 (12), p.1381-1385

1995

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Albumin Binding and Time Action of Acylated Insulins in Various Species

Journal of pharmaceutical sciences, 1996-03, Vol.85 (3), p.304-308

1996

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Equivalent in vivo biological activity of insulin analogues and human insulin despite different in vitro potencies

Diabetes (New York, N.Y.), 1990-09, Vol.39 (9), p.1033-1039

1990

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Insulin analogues with improved absorption characteristics

Hormone and metabolic research. Supplement series, 1992, Vol.26, p.125

1992

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β-Cell function and islet morphology in normal, obese, and obese β-cell mass-reduced Göttingen minipigs

American journal of physiology: endocrinology and metabolism, 2005-02, Vol.51 (2), p.E412-E421

2005

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GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: Selection of NN2211 for clinical development

Drugs of the Future, 2001, Vol.26 (7), p.677

2001

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Application of the euglycaemic clamp technique to bioassay of insulin analogues

Biologicals, 1992-06, Vol.20 (2), p.135-142

1992

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Basal 24 hours insulin therapy by a single sc. injection: Improved metabolic control obtained in diabetic Göttingen mini pigs

Diabetes research and clinical practice, 2000-09, Vol.50, p.81-81

2000

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Effect of the protracted GLP-1 derivative NN2211 in betacell reduced minipig

Diabetes research and clinical practice, 2000-09, Vol.50, p.383-384

2000

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Insulin detemir is a fully efficacious, low affinity agonist at the insulin receptor

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin

Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs

Action profile of cobalt(III)-insulin. A novel principle of protraction of potential use for basal insulin delivery

Enhanced Insulin Secretion and Improved Glucose Tolerance in Mice Lacking CD26

Hypothalamic CART is a new anorectic peptide regulated by leptin

GLP‐1 derivative liraglutide in rats with β‐cell deficiencies: influence of metabolic state on β‐cell mass dynamics

Monomeric insulins obtained by protein engineering and their medical implications

Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives

Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks

In Vitro and In Vivo Potency of Insulin Analogues Designed for Clinical Use

Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV

Chamber-Dependent Expression of Brain Natriuretic Peptide and Its mRNA in Normal and Diabetic Pig Heart

Kernel Function Smoothing of Insulin Absorption Kinetics

Action profile of cobalt(III)-insulin. A novel principle of protraction of potential use for basal insulin delivery

Albumin Binding and Time Action of Acylated Insulins in Various Species

Equivalent in vivo biological activity of insulin analogues and human insulin despite different in vitro potencies

Insulin analogues with improved absorption characteristics

β-Cell function and islet morphology in normal, obese, and obese β-cell mass-reduced Göttingen minipigs

GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: Selection of NN2211 for clinical development

Application of the euglycaemic clamp technique to bioassay of insulin analogues

Basal 24 hours insulin therapy by a single sc. injection: Improved metabolic control obtained in diabetic Göttingen mini pigs

Effect of the protracted GLP-1 derivative NN2211 in betacell reduced minipig

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