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Hot Spots for Allosteric Regulation on Protein Surfaces

Cell, 2011-12, Vol.147 (7), p.1564-1575

2011

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Evolution-Based Functional Decomposition of Proteins

PLoS computational biology, 2016-06, Vol.12 (6), p.e1004817-e1004817

2016

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The genetic landscape of a metabolic interaction

Nature communications, 2024-04, Vol.15 (1), p.3351-3351, Article 3351

2024

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An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Nature communications, 2018-03, Vol.9 (1), p.1138-15, Article 1138

2018

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Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme

eLife, 2020-07, Vol.9

2020

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Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily

Scientific reports, 2017-06, Vol.7 (1), p.3207-9, Article 3207

2017

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Structurally distributed surface sites tune allosteric regulation

eLife, 2021-06, Vol.10

2021

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Finding a Common Path: Predicting Gene Function using Inferred Evolutionary Trees

Developmental cell, 2014-07, Vol.30 (1), p.4-5

Reynolds, Kimberly A.

2014

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A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Cell reports (Cambridge), 2019-06, Vol.27 (11), p.3359-3370.e7

2019

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Quantifying the evolvability of allostery at different protein surfaces

Biophysical journal, 2023-02, Vol.122 (3), p.50a-51a

2023

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Strategies for Engineering and Rewiring Kinase Regulation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2020-03, Vol.45 (3), p.259-271

2020

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A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth

Nucleic acids research, 2021-01, Vol.49 (1), p.e6-e6

2021

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High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Molecular biology and evolution, 2019-07, Vol.36 (7), p.1533-1550

2019

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Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information

Cold Spring Harbor perspectives in biology, 2024-04, Vol.16 (4), p.a041463

2024

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Determining the mechanisms of the allosteric architecture of DHFR

Biophysical journal, 2023-02, Vol.122 (3), p.49a-49a

2023

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A New Test of Computational Protein Design: Predicting Posttranslational Modification Specificity for the Enzyme SMYD2

Structure (London), 2015-01, Vol.23 (1), p.11-12

Reynolds, Kimberly A.

2015

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An evolution-based strategy for engineering allosteric regulation

Physical biology, 2017-04, Vol.14 (2), p.025002-025002

2017

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Irreversibility in bacterial regulatory networks

Science advances, 2024-08, Vol.10 (35), p.eado3232

2024

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Accelerating Biological Insight for Understudied Genes

Integrative and comparative biology, 2022-02, Vol.61 (6), p.2233-2243

2022

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Engineering allosteric regulation in protein kinases

Science signaling, 2018-11, Vol.11 (555)

2018

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Identifying conformational changes of the β2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

Journal of computer-aided molecular design, 2009-05, Vol.23 (5), p.273-288

2009

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Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction

Biochemistry (Easton), 2015-07, Vol.54 (27), p.4248-4258

2015

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Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

Journal of computer-aided molecular design, 2009-05, Vol.23 (5), p.273-288

2009

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A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment

Cell systems, 2024-02, Vol.15 (2), p.134-148.e7

2024

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Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

Journal of molecular recognition, 2009-07, Vol.22 (4), p.307-318

2009

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Hot Spots for Allosteric Regulation on Protein Surfaces

Evolution-Based Functional Decomposition of Proteins

The genetic landscape of a metabolic interaction

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme

Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily

Structurally distributed surface sites tune allosteric regulation

Finding a Common Path: Predicting Gene Function using Inferred Evolutionary Trees

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Quantifying the evolvability of allostery at different protein surfaces

Strategies for Engineering and Rewiring Kinase Regulation

A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information

Determining the mechanisms of the allosteric architecture of DHFR

A New Test of Computational Protein Design: Predicting Posttranslational Modification Specificity for the Enzyme SMYD2

An evolution-based strategy for engineering allosteric regulation

Irreversibility in bacterial regulatory networks

Accelerating Biological Insight for Understudied Genes

Engineering allosteric regulation in protein kinases

Identifying conformational changes of the β2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment

Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

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