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Antibacterial targets in fatty acid biosynthesis

Current opinion in microbiology, 2007-10, Vol.10 (5), p.447-453

2007

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Antimalarial Activity of Natural and Synthetic Prodiginines

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5296-5306

2011

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MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway

Organic letters, 2017-03, Vol.19 (6), p.1298-1301

2017

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Elucidation of Final Steps of the Marineosins Biosynthetic Pathway through Identification and Characterization of the Corresponding Gene Cluster

Journal of the American Chemical Society, 2014-03, Vol.136 (12), p.4565-4574

2014

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Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Molecular cell, 2015-06, Vol.58 (5), p.832-844

2015

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Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (30), p.12295-12300

2009

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Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

The Journal of biological chemistry, 2011-06, Vol.286 (25), p.22558-22569

2011

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Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

ACS chemical biology, 2009-01, Vol.4 (1), p.41-52

2009

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Synthesis and Structure–Activity Relationships of Tambjamines and B‑Ring Functionalized Prodiginines as Potent Antimalarials

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7286-7309

2015

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Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

Journal of Bacteriology, 2005-06, Vol.187 (11), p.3795-3799

2005

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Total Synthesis and Antimalarial Activity of 2‑(p‑Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8739-8754

2021

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1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

Antimicrobial Agents and Chemotherapy, 2004-08, Vol.48 (8), p.3093-3102

2004

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Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in Phoslactomycin Biosynthesis

Journal of the American Chemical Society, 2007-02, Vol.129 (7), p.1910-1911

2007

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An O-Phosphotransferase Catalyzes Phosphorylation of Hygromycin A in the Antibiotic-Producing Organism Streptomyces hygroscopicus

Antimicrobial Agents and Chemotherapy, 2008-10, Vol.52 (10), p.3580-3588

2008

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Purification, Characterization, and Identification of Novel Inhibitors of the β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2002-05, Vol.46 (5), p.1310-1318

2002

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Stereospecific Synthesis of 23-Hydroxyundecylprodiginines and Analogues and Conversion to Antimalarial Premarineosins via a Rieske Oxygenase Catalyzed Bicyclization

Journal of organic chemistry, 2014-12, Vol.79 (23), p.11674-11689

2014

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Biochemical Evidence for an Editing Role of Thioesterase II in the Biosynthesis of the Polyketide Pikromycin

The Journal of biological chemistry, 2002-12, Vol.277 (50), p.48028-48034

2002

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Characterization of FabG and FabI of the Streptomyces coelicolor Dissociated Fatty Acid Synthase

Chembiochem : a European journal of chemical biology, 2015-03, Vol.16 (4), p.631-640

2015

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Application of a Newly Identified and Characterized 18-O-Acyltransferase in Chemoenzymatic Synthesis of Selected Natural and Nonnatural Bioactive Derivatives of Phoslactomycins

Applied and Environmental Microbiology, 2009-06, Vol.75 (11), p.3469-3476

2009

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Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor

Journal of natural products (Washington, D.C.), 2016-01, Vol.79 (1), p.240-243

2016

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Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8323-8345

2024

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The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5″-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.5163-5172

2009

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Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids

Chembiochem : a European journal of chemical biology, 2016-08, Vol.17 (15), p.1426-1429

2016

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Enhancement and Selective Production of Phoslactomycin B, a Protein Phosphatase IIa Inhibitor, through Identification and Engineering of the Corresponding Biosynthetic Gene Cluster

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35552-35557

2003

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Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis

Journal of Bacteriology, 1998-09, Vol.180 (17), p.4481-4486

1998

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Antibacterial targets in fatty acid biosynthesis

Antimalarial Activity of Natural and Synthetic Prodiginines

MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway

Elucidation of Final Steps of the Marineosins Biosynthetic Pathway through Identification and Characterization of the Corresponding Gene Cluster

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

Synthesis and Structure–Activity Relationships of Tambjamines and B‑Ring Functionalized Prodiginines as Potent Antimalarials

Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

Total Synthesis and Antimalarial Activity of 2‑(p‑Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria

1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in Phoslactomycin Biosynthesis

An O-Phosphotransferase Catalyzes Phosphorylation of Hygromycin A in the Antibiotic-Producing Organism Streptomyces hygroscopicus

Purification, Characterization, and Identification of Novel Inhibitors of the β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus

Stereospecific Synthesis of 23-Hydroxyundecylprodiginines and Analogues and Conversion to Antimalarial Premarineosins via a Rieske Oxygenase Catalyzed Bicyclization

Biochemical Evidence for an Editing Role of Thioesterase II in the Biosynthesis of the Polyketide Pikromycin

Characterization of FabG and FabI of the Streptomyces coelicolor Dissociated Fatty Acid Synthase

Application of a Newly Identified and Characterized 18-O-Acyltransferase in Chemoenzymatic Synthesis of Selected Natural and Nonnatural Bioactive Derivatives of Phoslactomycins

Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor

Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents

The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5″-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux

Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids

Enhancement and Selective Production of Phoslactomycin B, a Protein Phosphatase IIa Inhibitor, through Identification and Engineering of the Corresponding Biosynthetic Gene Cluster

Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis

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