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A general method to improve fluorophores for live-cell and single-molecule microscopy

Nature methods, 2015-03, Vol.12 (3), p.244-250

2015

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Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

Cell, 2014-03, Vol.156 (6), p.1274-1285

2014

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Whole-cell, multicolor superresolution imaging using volumetric multifocus microscopy

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (49), p.17480-17485

2014

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Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching

Science (American Association for the Advancement of Science), 2006-11, Vol.314 (5802), p.1139-1143

2006

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A Single-Molecule Surface-Based Platform to Detect the Assembly and Function of the Human RNA Polymerase II Transcription Machinery

Structure (London), 2020-12, Vol.28 (12), p.1337-1343.e4

2020

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Single-molecule tracking of the transcription cycle by sub-second RNA detection

eLife, 2014-01, Vol.3, p.e01775

2014

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Transcription initiation by human RNA polymerase II visualized at single-molecule resolution

Genes & development, 2012-08, Vol.26 (15), p.1691-1702

2012

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Promoter Unwinding and Promoter Clearance by RNA Polymerase: Detection by Single-Molecule DNA Nanomanipulation

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (14), p.4776-4780

2004

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Cloud-point PEG Glass Surfaces for Imaging of Immobilized Single Molecules by Total-internal-reflection Microscopy

Bio-protocol, 2016-04, Vol.6 (7)

2016

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Structural organization of the RNA polymerase-promoter open complex

Cell, 2000-06, Vol.101 (6), p.601-611

2000

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Functionalizing DNA Origami by Triplex-Directed Site-Specific Photo-Cross-Linking

Journal of the American Chemical Society, 2024-05, Vol.146 (19), p.13617-13628

2024

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Single-Molecule Dynamics of the Human RNA Polymerase II Preinitiation Complex

Biophysical journal, 2020-02, Vol.118 (3), p.188a-188a

2020

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A Single-Molecule Surface-Based Platform for Detecting the Assembly and Function of the Human RNA Polymerase II Transcription Machinery

Structure (London), 2020-08, Vol.28 (12), p.1337-1343.e4

2020

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Single-Molecule Dynamics of the Human Mitochondrial RNA Polymerase Preinitiation Complex

Biophysical journal, 2020-02, Vol.118 (3), p.465a-465a

2020

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Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

Genes & development, 2016-09, Vol.30 (18), p.2106-2118

2016

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Single-Molecule Insights on Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex and the Roles of Activators

Biophysical journal, 2013-01, Vol.104 (2), p.365a-366a

2013

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Single-molecule DNA nanomanipulation: Improved resolution through use of shorter DNA fragments

Nature methods, 2005-02, Vol.2 (2), p.127-138

2005

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Single-Molecule Insights on the Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex, Re-Initiation Scaffold, and the Roles of Activators

Biophysical journal, 2012-01, Vol.102 (3), p.228a-229a

2012

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Mechanics of Transcription Elongation Through The Nucleosome Using Single-Molecule and Biochemical Methods

Biophysical journal, 2009-02, Vol.96 (3), p.57a-57a

2009

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Single-molecule studies using magnetic traps

Cold Spring Harbor protocols, 2012-01, Vol.2012 (1), p.34

2012

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Magnetic trap construction

Cold Spring Harbor protocols, 2012-01, Vol.2012 (1), p.133

2012

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Assembly and Regulation of the Human RNA Polymerase II Preinitiation Complex: A Single-Molecule Approach to a Complex Biological System

Biophysical journal, 2011-02, Vol.100 (3), p.10a-10a

2011

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ABORTIVE INITIATION AND PRODUCTIVE INITIATION BY RNA POLYMERASE INVOLVE DNA SCRUNCHING: Single-molecule-nanomanipulation experiments--in which magnetic tweezers are used to monitor RNA-polymerase-induced DNA unwinding with ~1 bp resolution and ~1 s temporal resolution--show that both abortive initiation and productive initiation by RNA polymerase involve DNA “scrunching.”

Science (American Association for the Advancement of Science), 2006-11, Vol.314 (5802), p.1139-1143

2006

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Magnetic Trap Construction: Figure 1

Cold Spring Harbor protocols, 2012-01, Vol.2012 (1), p.pdb.prot067496

2012

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Site-Specific Protein-DNA Photo-Cross-Linking: Analysis of Structural Organization of Protein-DNA and Multiprotein-DNA Complexes

Cold Spring Harbor protocols, 2006-11, Vol.2006 (6), p.pdb.prot4588

2006

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A general method to improve fluorophores for live-cell and single-molecule microscopy

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

Whole-cell, multicolor superresolution imaging using volumetric multifocus microscopy

Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching

A Single-Molecule Surface-Based Platform to Detect the Assembly and Function of the Human RNA Polymerase II Transcription Machinery

Single-molecule tracking of the transcription cycle by sub-second RNA detection

Transcription initiation by human RNA polymerase II visualized at single-molecule resolution

Promoter Unwinding and Promoter Clearance by RNA Polymerase: Detection by Single-Molecule DNA Nanomanipulation

Cloud-point PEG Glass Surfaces for Imaging of Immobilized Single Molecules by Total-internal-reflection Microscopy

Structural organization of the RNA polymerase-promoter open complex

Functionalizing DNA Origami by Triplex-Directed Site-Specific Photo-Cross-Linking

Single-Molecule Dynamics of the Human RNA Polymerase II Preinitiation Complex

A Single-Molecule Surface-Based Platform for Detecting the Assembly and Function of the Human RNA Polymerase II Transcription Machinery

Single-Molecule Dynamics of the Human Mitochondrial RNA Polymerase Preinitiation Complex

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

Single-Molecule Insights on Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex and the Roles of Activators

Single-molecule DNA nanomanipulation: Improved resolution through use of shorter DNA fragments

Single-Molecule Insights on the Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex, Re-Initiation Scaffold, and the Roles of Activators

Mechanics of Transcription Elongation Through The Nucleosome Using Single-Molecule and Biochemical Methods

Single-molecule studies using magnetic traps

Magnetic trap construction

Assembly and Regulation of the Human RNA Polymerase II Preinitiation Complex: A Single-Molecule Approach to a Complex Biological System

Magnetic Trap Construction: Figure 1

Site-Specific Protein-DNA Photo-Cross-Linking: Analysis of Structural Organization of Protein-DNA and Multiprotein-DNA Complexes

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