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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

PloS one, 2018-06, Vol.13 (6), p.e0199108-e0199108

2018

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ALK-activating homologous mutations in LTK induce cellular transformation

PloS one, 2012-02, Vol.7 (2), p.e31733

2012

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Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.2228-2241

2021

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JAK2 inhibitor persistence in MPN: uncovering a central role of ERK activation

Blood cancer journal (New York), 2022-01, Vol.12 (1), p.13-13, Article 13

2022

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CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in Oncogenesis

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (19), p.7347-7352

2010

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Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms

Frontiers in immunology, 2020-11, Vol.11, p.604142-604142

2020

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Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis

Cancers, 2020-08, Vol.12 (8), p.2278

2020

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SHP2 inhibition displays efficacy as a monotherapy and in combination with JAK2 inhibition in preclinical models of myeloproliferative neoplasms

American journal of hematology, 2024-06, Vol.99 (6), p.1040-1055

2024

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Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach

Proteomics (Weinheim), 2020-12, Vol.20 (24), p.e2000116-n/a

2020

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The Ras branch of small Gtpases: Ras family members don’t fall far from the tree

Current Opinion in Cell Biology, 2000-04, Vol.12 (2), p.157-165

2000

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Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Clinical cancer research, 2023-08, Vol.29 (15), p.2919-2932

2023

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Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1054-1067

2017

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The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

Oncotarget, 2015-11, Vol.6 (37), p.40141-40157

2015

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Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

Cancer research (Chicago, Ill.), 2016-06, Vol.76 (12), p.3531-3540

2016

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Nature cell biology, 2002-08, Vol.4 (8), p.621-625

2002

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JAK2‐V617F‐mediated signalling is dependent on lipid rafts and statins inhibit JAK2‐V617F‐dependent cell growth

British journal of haematology, 2013-01, Vol.160 (2), p.177-187

2013

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Regulation of MDMX Expression by Mitogenic Signaling

Molecular and Cellular Biology, 2008-03, Vol.28 (6), p.1999-2010

2008

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Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (47), p.18502-18507

2007

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Aggressive myeloid leukemia formation is directed by the Musashi 2/Numb pathway

Cancer biology & therapy, 2010-11, Vol.10 (10), p.979-982

2010

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Porphyrin overdrive rewires cancer cell metabolism

Life science alliance, 2024-07, Vol.7 (7), p.e202302547

2024

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Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients

Journal of thoracic oncology, 2017-12, Vol.12 (12), p.1851-1856

2017

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Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

Biochemical journal, 2011-08, Vol.438 (1), p.155-164

2011

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Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ

Biochemical journal, 2010-12, Vol.432 (2), p.255-265

2010

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Activation of JAK2-V617F by Components of Heterodimeric Cytokine Receptors

The Journal of biological chemistry, 2010-05, Vol.285 (22), p.16651-16663

2010

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JAK2 activation in myeloproliferative neoplasms: A potential role for heterodimeric receptors

Cell cycle (Georgetown, Tex.), 2008-03, Vol.7 (6), p.714-719

Reuther, Gary W.

2008

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

ALK-activating homologous mutations in LTK induce cellular transformation

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

JAK2 inhibitor persistence in MPN: uncovering a central role of ERK activation

CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in Oncogenesis

Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms

Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis

SHP2 inhibition displays efficacy as a monotherapy and in combination with JAK2 inhibition in preclinical models of myeloproliferative neoplasms

Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach

The Ras branch of small Gtpases: Ras family members don’t fall far from the tree

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

JAK2‐V617F‐mediated signalling is dependent on lipid rafts and statins inhibit JAK2‐V617F‐dependent cell growth

Regulation of MDMX Expression by Mitogenic Signaling

Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor

Aggressive myeloid leukemia formation is directed by the Musashi 2/Numb pathway

Porphyrin overdrive rewires cancer cell metabolism

Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ

Activation of JAK2-V617F by Components of Heterodimeric Cytokine Receptors

JAK2 activation in myeloproliferative neoplasms: A potential role for heterodimeric receptors

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