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MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist

British journal of pharmacology, 1998-01, Vol.123 (1), p.81-91

1998

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Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis

Neuropharmacology, 2000-07, Vol.39 (8), p.1422-1429

2000

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Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon

Naunyn-Schmiedeberg's archives of pharmacology, 1999-05, Vol.359 (5), p.420-427

1999

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Successful bridging from a peptide to a non peptide antagonist at the human tachykinin NK-2 receptor

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2945-2948

2002

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Discovery of Potent Cyclic Pseudopeptide Human Tachykinin NK-2 Receptor Antagonists

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4041-4044

2000

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MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors

The Journal of pharmacology and experimental therapeutics, 1994-12, Vol.271 (3), p.1489

1994

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Insertion of 2-Carboxysuccinate and Tricarballylic Acid Fragments into Cyclic-Pseudopeptides: New Antagonists for the Human Tachykinin NK-2 Receptor

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.693-696

2002

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Down-regulation of substance P receptors during colitis induced by trinitrobenzene sulfonic acid in rats

Neuropeptides (Edinburgh), 1996-10, Vol.30 (5), p.425-428

1996

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Regio- and Stereoselective Cycloadditions of Cyclic Nitrones to Maleic Diamide Forced in a Peptide: Synthesis of Potent Ligands of Human NK-2 Receptor

Journal of organic chemistry, 2000-06, Vol.65 (13), p.4003-4008

2000

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1,2-cyclomethylenecarboxylic monoamide hydroxamic derivatives. A novel class of non-amino acid angiotensin converting enzyme inhibitors

Journal of medicinal chemistry, 1993-03, Vol.36 (6), p.699-707

1993

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Effects of tyrosine289phenylalanine mutation on binding and functional properties of the human tachykinin NK2 receptor stably expressed in Chinese hamster ovary cells

Biochemical pharmacology, 1999-04, Vol.57 (8), p.899-906

1999

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Characterization of [3H]MEN 11420, a novel glycosylated peptide antagonist radioligand of the tachykinin NK2 receptor

Biochemical and biophysical research communications, 1998-07, Vol.248 (1), p.78-82

1998

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Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Journal of medicinal chemistry, 1994-11, Vol.37 (23), p.3928-3938

1994

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Role of Calcium in Angiotensin II-Induced Prostaglandin Release and DNA Synthesis in Rat Vascular Smooth Muscle Cells

Journal of cardiovascular pharmacology, 1996-02, Vol.27 (2), p.195-200

1996

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Tachykinin NK2 receptors: characterization in the rat small intestine by the use of a peptide agonist and a nonpeptide antagonist as radioligands

Naunyn-Schmiedeberg's archives of pharmacology, 1997-07, Vol.356 (1), p.139-144

1997

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A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627

Regulatory peptides, 1996-08, Vol.65 (1), p.55-59

1996

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Angiotensins induce the release of prostacyclin from rabbit vas deferens: evidence for receptor heterogeneity

European journal of pharmacology, 1994-04, Vol.256 (1), p.93-97

1994

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Human umbilical vein smooth muscle cells as a model to study thrombin generation and function: effect of thrombin inhibitors

Thrombosis and haemostasis, 1996-10, Vol.76 (4), p.603-609

1996

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Characterization of NK-3 binding sites in rat and guinea pig cortical membranes by the selective ligand [ 3H]Senktide

Neuropeptides (Edinburgh), 1991-03, Vol.18 (3), p.107-114

1991

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Selectivity of LG50643 for Postjunctional Muscarinic-receptor Subtype in the Guinea-pig Trachea

Journal of pharmacy and pharmacology, 1994-05, Vol.46 (5), p.332-336

1994

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Inactivation of brain cortex muscarinic receptors by 4-diphenylacetoxy-1-(2-chloroethyl) piperidine mustard

Biochemical pharmacology, 1992-07, Vol.44 (2), p.285-290

1992

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[125I]His-neurokinin A binds selectively to NK2 receptors of the B-type in rat small intestine smooth muscle membranes

European journal of pharmacology, 1992-10, Vol.227 (2), p.163-171

1992

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Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells

Regulatory peptides, 1995-04, Vol.56 (2), p.175-184

1995

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Synthesis of biphenylyltetrazole derivatives of 1-aminopyrroles as angiotensin II antagonists

Farmaco (Società chimica italiana : 1989), 1999, Vol.54 (1), p.64-76

1999

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Heterogeneity of tachykinin NK-2 receptors in rabbit, guinea-pig and human smooth muscles

Neuropeptides (Edinburgh), 1992-11, Vol.23 (3), p.181-186

1992

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MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist

Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis

Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon

Successful bridging from a peptide to a non peptide antagonist at the human tachykinin NK-2 receptor

Discovery of Potent Cyclic Pseudopeptide Human Tachykinin NK-2 Receptor Antagonists

MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors

Insertion of 2-Carboxysuccinate and Tricarballylic Acid Fragments into Cyclic-Pseudopeptides: New Antagonists for the Human Tachykinin NK-2 Receptor

Down-regulation of substance P receptors during colitis induced by trinitrobenzene sulfonic acid in rats

Regio- and Stereoselective Cycloadditions of Cyclic Nitrones to Maleic Diamide Forced in a Peptide: Synthesis of Potent Ligands of Human NK-2 Receptor

1,2-cyclomethylenecarboxylic monoamide hydroxamic derivatives. A novel class of non-amino acid angiotensin converting enzyme inhibitors

Effects of tyrosine289phenylalanine mutation on binding and functional properties of the human tachykinin NK2 receptor stably expressed in Chinese hamster ovary cells

Characterization of [3H]MEN 11420, a novel glycosylated peptide antagonist radioligand of the tachykinin NK2 receptor

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

Role of Calcium in Angiotensin II-Induced Prostaglandin Release and DNA Synthesis in Rat Vascular Smooth Muscle Cells

Tachykinin NK2 receptors: characterization in the rat small intestine by the use of a peptide agonist and a nonpeptide antagonist as radioligands

A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627

Angiotensins induce the release of prostacyclin from rabbit vas deferens: evidence for receptor heterogeneity

Human umbilical vein smooth muscle cells as a model to study thrombin generation and function: effect of thrombin inhibitors

Characterization of NK-3 binding sites in rat and guinea pig cortical membranes by the selective ligand [ 3H]Senktide

Selectivity of LG50643 for Postjunctional Muscarinic-receptor Subtype in the Guinea-pig Trachea

Inactivation of brain cortex muscarinic receptors by 4-diphenylacetoxy-1-(2-chloroethyl) piperidine mustard

[125I]His-neurokinin A binds selectively to NK2 receptors of the B-type in rat small intestine smooth muscle membranes

Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells

Synthesis of biphenylyltetrazole derivatives of 1-aminopyrroles as angiotensin II antagonists

Heterogeneity of tachykinin NK-2 receptors in rabbit, guinea-pig and human smooth muscles

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