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Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients

Food and chemical toxicology, 2007-12, Vol.45 (12), p.2533-2562

2007

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Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

Food and chemical toxicology, 2004, Vol.42 (1), p.65-83

2004

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Toxicology of Micronutrients: Adverse Effects and Uncertainty

The Journal of nutrition, 2006-02, Vol.136 (2), p.493S-501S

Renwick, A. G

2006

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The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans

Toxicological sciences, 2005-07, Vol.86 (1), p.20-26

2005

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Risk assessment of substances that are both genotoxic and carcinogenic Report of an International Conference organized by EFSA and WHO with support of ILSI Europe

Food and chemical toxicology, 2006-10, Vol.44 (10), p.1636-1650

2006

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Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review

Food and chemical toxicology, 2005-02, Vol.43 (2), p.203-216

2005

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Approaches to the risk assessment of genotoxic carcinogens in food: A critical appraisal

Food and chemical toxicology, 2006-10, Vol.44 (10), p.1613-1635

2006

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Risk characterisation of chemicals in food and diet

Food and chemical toxicology, 2003-09, Vol.41 (9), p.1211-1271

2003

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Risk–benefit analysis of micronutrients

Food and chemical toxicology, 2004-12, Vol.42 (12), p.1903-1922

2004

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Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents

Toxicology letters, 2004-04, Vol.149 (1), p.223-234

Renwick, A.G

2004

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First European conference on aspartame: Putting safety and benefits into perspective. Synopsis of presentations and conclusions

Food and chemical toxicology, 2007-07, Vol.45 (7), p.1308-1313

2007

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Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

Food and chemical toxicology, 2003-02, Vol.41 (2), p.201-224

2003

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The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis

British journal of dermatology (1951), 2003-03, Vol.148 (3), p.434-443

2003

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Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements

Food and chemical toxicology, 2003-12, Vol.41 (12), p.1625-1649

2003

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Hazard characterisation of chemicals in food and diet: dose response, mechanisms and extrapolation issues

Food and chemical toxicology, 2002-02, Vol.40 (2), p.237-282

2002

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Human Variability and Noncancer Risk Assessment— An Analysis of the Default Uncertainty Factor

Regulatory toxicology and pharmacology, 1998-02, Vol.27 (1), p.3-20

1998

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Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

Food and chemical toxicology, 2002-11, Vol.40 (11), p.1633-1656

2002

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Species-specific uncertainty factors for compounds eliminated principally by renal excretion in humans

Food and chemical toxicology, 2004-02, Vol.42 (2), p.261-274

2004

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Uncertainty factors for chemical risk assessment: human variability in the pharmacokinetics of CYP1A2 probe substrates

Food and chemical toxicology, 2001-07, Vol.39 (7), p.681-696

2001

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The Threshold of Toxicological Concern (TTC) in risk assessment

Toxicology letters, 2008-08, Vol.180 (2), p.151-156

2008

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Evaluation of the Threshold of Toxicological Concern (TTC) – Challenges and approaches

Regulatory toxicology and pharmacology, 2013-02, Vol.65 (1), p.168-177

2013

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The metabolism of cyclamate to cyclohexylamine in humans during long-term administration

Toxicology and applied pharmacology, 2004-05, Vol.196 (3), p.367-380

2004

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Sucralose metabolism and pharmacokinetics in man

Food and chemical toxicology, 2000-01, Vol.38, p.31-41

2000

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Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment

Food and chemical toxicology, 2004-02, Vol.42 (2), p.275-298

2004

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The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

Clinical and experimental allergy, 1999-07, Vol.29 (S3), p.116-124

Renwick, A. G.

1999

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Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients

Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

Toxicology of Micronutrients: Adverse Effects and Uncertainty

The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans

Risk assessment of substances that are both genotoxic and carcinogenic Report of an International Conference organized by EFSA and WHO with support of ILSI Europe

Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review

Approaches to the risk assessment of genotoxic carcinogens in food: A critical appraisal

Risk characterisation of chemicals in food and diet

Risk–benefit analysis of micronutrients

Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents

First European conference on aspartame: Putting safety and benefits into perspective. Synopsis of presentations and conclusions

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis

Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements

Hazard characterisation of chemicals in food and diet: dose response, mechanisms and extrapolation issues

Human Variability and Noncancer Risk Assessment— An Analysis of the Default Uncertainty Factor

Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?

Species-specific uncertainty factors for compounds eliminated principally by renal excretion in humans

Uncertainty factors for chemical risk assessment: human variability in the pharmacokinetics of CYP1A2 probe substrates

The Threshold of Toxicological Concern (TTC) in risk assessment

Evaluation of the Threshold of Toxicological Concern (TTC) – Challenges and approaches

The metabolism of cyclamate to cyclohexylamine in humans during long-term administration

Sucralose metabolism and pharmacokinetics in man

Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment

The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

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