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Two-dimensional liquid chromatography-mass spectrometry for the characterization of modified oligonucleotide impurities

Analytical biochemistry, 2018-09, Vol.556, p.45-52

2018

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Semi-quantitative determination of co-eluting impurities in oligonucleotide drugs using ion-pair reversed-phase liquid chromatography mass spectrometry

Journal of Chromatography A, 2019-01, Vol.1584, p.106-114

2019

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Small alkyl amines as ion-pair reagents for the separation of positional isomers of impurities in phosphate diester oligonucleotides

Journal of Chromatography A, 2019-06, Vol.1594, p.105-111

2019

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Characterizing the Diastereoisomeric Distribution of Phosphorothioate Oligonucleotides by Metal Ion Complexation Chromatography, In-Series Reversed Phase-Strong Anion Exchange Chromatography, and 31P NMR

Analytical chemistry (Washington), 2021-12, Vol.93 (48), p.16035-16042

2021

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Exploring the use of the desirability function to optimize the separation of oligonucleotide impurities by ion pair-RP LCMS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023-04, Vol.1220, p.123666-123666, Article 123666

2023

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Characterizing the Diastereoisomeric Distribution of Phosphorothioate Oligonucleotides by Metal Ion Complexation Chromatography, In-Series Reversed Phase-Strong Anion Exchange Chromatography, and 31 P NMR

Analytical chemistry (Washington), 2021-12, Vol.93 (48), p.16035-16042

2021

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Effect of diastereoisomeric composition on the chromatographic retention of phosphorothioated oligonucleotides using three different liquid chromatography systems

Journal of Chromatography A, 2024-08, Vol.1730, p.465108, Article 465108

2024

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Automated determination of early eluting oligonucleotide impurities using ion-pair reversed-phase liquid chromatography high resolution-mass spectrometry

Analytical biochemistry, 2020-04, Vol.595, p.113623-113623, Article 113623

2020

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Determination of individual oligonucleotide impurities by small amine ion pair-RP HPLC MS and MS/MS: n − 1 impurities

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021-04, Vol.1169, p.122611-122611, Article 122611

2021

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Silver-Plated Vitamins: A Method of Detecting Tocopherols and Carotenoids in LC/ESI-MS Coupling

Analytical chemistry (Washington), 1998-10, Vol.70 (20), p.4394-4400

1998

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Assay determination by mass spectrometry for oligonucleotide therapeutics

Rapid communications in mass spectrometry, 2019-11, Vol.33 (22), p.1774-1780

2019

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Separation and Identification of Tocotrienol Isomers by HPLC−MS and HPLC−NMR Coupling

Analytical chemistry (Washington), 1999-05, Vol.71 (9), p.1780-1785

1999

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Determination of oligonucleotide deamination by high resolution mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2019-09, Vol.173, p.56-61

2019

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Formation of Modified Cytosine Residues in the Presence of Depurinated DNA

Journal of organic chemistry, 2005-09, Vol.70 (20), p.7841-7845

2005

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Coupling of capillary electrochromatography to coordination ion spray mass spectrometry, a novel detection method

Electrophoresis, 1999-08, Vol.20 (12), p.2329-2336

1999

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Rapid Oligonucleotide Drug Impurity Determination by Direct Spectral Comparison of Ion Pair-Reversed Phase HPLC ESI MS Data

Rapid communications in mass spectrometry, 2018-03

2018

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Coordination-Ionspray-MS (CIS-MS), a Universal Detection and Characterization Method for Direct Coupling with Separation Techniques

Angewandte Chemie (International ed.), 1999-04, Vol.38 (7), p.992-995

1999

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Efficient synthesis of antisense phosphorothioate oligonucleotides using a universal solid support

Tetrahedron, 2006-05, Vol.62 (18), p.4528-4534

2006

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Trichloroacetaldehyde modified oligonucleotides

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (18), p.4118-4124

2005

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Koordinations-Ionenspray-MS (CIS-MS), eine universelle Methode zur Detektion und Charakterisierung für die Direktkopplung mit Trennmethoden

Angewandte Chemie, 1999-04, Vol.111 (7), p.1046-1049

1999

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Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

Organic process research & development, 2003-05, Vol.7 (3), p.259-266

2003

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Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Organic process research & development, 2003-11, Vol.7 (6), p.917-920

2003

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Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

Nucleosides, nucleotides & nucleic acids, 2003-01, Vol.22 (4), p.461-468

2003

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Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Nucleosides, nucleotides & nucleic acids, 2004-05, Vol.23 (5), p.767-775

2004

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Koordinations‐Ionenspray‐MS (CIS‐MS), eine universelle Methode zur Detektion und Charakterisierung für die Direktkopplung mit Trennmethoden

Angewandte Chemie, 1999-04, Vol.111 (7), p.1046-1049

1999

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Two-dimensional liquid chromatography-mass spectrometry for the characterization of modified oligonucleotide impurities

Semi-quantitative determination of co-eluting impurities in oligonucleotide drugs using ion-pair reversed-phase liquid chromatography mass spectrometry

Small alkyl amines as ion-pair reagents for the separation of positional isomers of impurities in phosphate diester oligonucleotides

Characterizing the Diastereoisomeric Distribution of Phosphorothioate Oligonucleotides by Metal Ion Complexation Chromatography, In-Series Reversed Phase-Strong Anion Exchange Chromatography, and 31P NMR

Exploring the use of the desirability function to optimize the separation of oligonucleotide impurities by ion pair-RP LCMS

Characterizing the Diastereoisomeric Distribution of Phosphorothioate Oligonucleotides by Metal Ion Complexation Chromatography, In-Series Reversed Phase-Strong Anion Exchange Chromatography, and 31 P NMR

Effect of diastereoisomeric composition on the chromatographic retention of phosphorothioated oligonucleotides using three different liquid chromatography systems

Automated determination of early eluting oligonucleotide impurities using ion-pair reversed-phase liquid chromatography high resolution-mass spectrometry

Determination of individual oligonucleotide impurities by small amine ion pair-RP HPLC MS and MS/MS: n − 1 impurities

Silver-Plated Vitamins: A Method of Detecting Tocopherols and Carotenoids in LC/ESI-MS Coupling

Assay determination by mass spectrometry for oligonucleotide therapeutics

Separation and Identification of Tocotrienol Isomers by HPLC−MS and HPLC−NMR Coupling

Determination of oligonucleotide deamination by high resolution mass spectrometry

Formation of Modified Cytosine Residues in the Presence of Depurinated DNA

Coupling of capillary electrochromatography to coordination ion spray mass spectrometry, a novel detection method

Rapid Oligonucleotide Drug Impurity Determination by Direct Spectral Comparison of Ion Pair-Reversed Phase HPLC ESI MS Data

Coordination-Ionspray-MS (CIS-MS), a Universal Detection and Characterization Method for Direct Coupling with Separation Techniques

Efficient synthesis of antisense phosphorothioate oligonucleotides using a universal solid support

Trichloroacetaldehyde modified oligonucleotides

Koordinations-Ionenspray-MS (CIS-MS), eine universelle Methode zur Detektion und Charakterisierung für die Direktkopplung mit Trennmethoden

Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Koordinations‐Ionenspray‐MS (CIS‐MS), eine universelle Methode zur Detektion und Charakterisierung für die Direktkopplung mit Trennmethoden

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