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Discovery and development of orexin receptor antagonists as therapeutics for insomnia

British journal of pharmacology, 2014-01, Vol.171 (2), p.283-293

2014

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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons

The Journal of neuroscience, 2012-07, Vol.32 (27), p.9374-9382

2012

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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

The Journal of neuroscience, 2015-10, Vol.35 (42), p.14234-14250

2015

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The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

Annual review of pharmacology and toxicology, 2017-01, Vol.57 (1), p.509-533

2017

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Three-dimensional manipulation with scanning near-field optical nanotweezers

Nature nanotechnology, 2014-04, Vol.9 (4), p.295-299

2014

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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Nature structural & molecular biology, 2016-04, Vol.23 (4), p.293-299

2016

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Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease

PloS one, 2014-07, Vol.9 (7), p.e103187-e103187

2014

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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology

Pharmacological reviews, 2012-07, Vol.64 (3), p.389-420

2012

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Essential thalamic contribution to slow waves of natural sleep

The Journal of neuroscience, 2013-12, Vol.33 (50), p.19599-19610

2013

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Deep-subwavelength imaging of the modal dispersion of light

Nature materials, 2012-08, Vol.11 (9), p.781-787

2012

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Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress

Neuroscience, 2017-04, Vol.348, p.313-323

2017

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Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist

Journal of neurogenetics, 2011-03, Vol.25 (1-2), p.52-61

2011

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GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons

The Journal of neuroscience, 2012-06, Vol.32 (23), p.7782-7790

2012

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Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

Nature neuroscience, 2011-04, Vol.14 (4), p.478-486

2011

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Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease

Neurobiology of aging, 2018-04, Vol.64, p.92-106

2018

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Scientific reports, 2016-06, Vol.6 (1), p.27147, Article 27147

2016

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Deep-subwavelength imaging of the modal dispersion of light

Nature materials, 2012-09, Vol.11 (9), p.781-787

2012

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A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12788

2023

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Calcineurin signaling mediates activity-dependent relocation of the axon initial segment

The Journal of neuroscience, 2013-04, Vol.33 (16), p.6950-6963

2013

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Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey

Psychopharmacology, 2015-06, Vol.232 (11), p.1859-1866

2015

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Orexin receptors as therapeutic drug targets

Progress in Brain Research, 2012, Vol.198, p.163-188

2012

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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Sleep (New York, N.Y.), 2016-03, Vol.39 (3), p.603-612

2016

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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Neuropharmacology, 2012-02, Vol.62 (2), p.978-987

2012

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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

BMC neuroscience, 2013-08, Vol.14 (1), p.90-90, Article 90

2013

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Discovery and development of orexin receptor antagonists as therapeutics for insomnia

Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

Three-dimensional manipulation with scanning near-field optical nanotweezers

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease

International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology

Essential thalamic contribution to slow waves of natural sleep

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Deep-subwavelength imaging of the modal dispersion of light

Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress

Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist

GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Deep-subwavelength imaging of the modal dispersion of light

A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development

Calcineurin signaling mediates activity-dependent relocation of the axon initial segment

Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey

Orexin receptors as therapeutic drug targets

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

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