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Selective reduction of N-oxides to amines: application to drug metabolism

Drug metabolism and disposition, 2004-09, Vol.32 (9), p.966

2004

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High performance liquid chromatographic enantioseparation development and analytical method characterization of the carboxylate ester of evacetrapib using an immobilized chiral stationary phase with a non-conventional eluent system

Journal of Chromatography A, 2015-10, Vol.1416, p.83-93

2015

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Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Organic process research & development, 2012-05, Vol.16 (5), p.982-1002

2012

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Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.740-749

2011

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Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Organic process research & development, 2012-05, Vol.16 (5), p.982-1002

2012

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Counterion effects in the preparation of aldehyde–bisulfite adducts

Tetrahedron letters, 2013-11, Vol.54 (48), p.6587-6591

2013

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Antimitotic agents: structure-activity studies with some pyridine derivatives

Journal of medicinal chemistry, 1992-10, Vol.35 (20), p.3686-3690

1992

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A method for the synthesis of 2-amino-4-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-[3H2]

Journal of labelled compounds & radiopharmaceuticals, 2004-08, Vol.47 (9), p.571-581

2004

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Differential Effects of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl Carbamate Analogs Modified at Position C2 on Tubulin Polymerization, Binding, and Conformational Changes

Biochemistry (Easton), 1995-12, Vol.34 (51), p.16821-16829

1995

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Kinetics of Association and Dissociation of Two Enantiomers, NSC 613863 (R)-(+) and NSC 613862 (S)-(−) (CI 980), to Tubulin

Biochemistry (Easton), 1996-02, Vol.35 (6), p.2008-2015

1996

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Tubulin binding of two 1-deaza-7,8-dihydropteridines with different biological properties: Enantiomers NSC 613862 (S)-(-) and NSC 613863 (R)-(+)

Biochemistry (Easton), 1993-10, Vol.32 (40), p.10675-10682

1993

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Antimitotic agents: ring analogs and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate

Journal of medicinal chemistry, 1992-12, Vol.35 (26), p.4809-4812

1992

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Antimitotic agents. Chiral isomers of ethyl 5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-ylcarbamate

Journal of medicinal chemistry, 1992-03, Vol.35 (6), p.988-993

1992

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Phosphonate Analogs of Carbocyclic Nucleotides

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.739-744

1994

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Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1746-1751

1987

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New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-carbamate

Journal of medicinal chemistry, 1989-09, Vol.32 (9), p.2089-2092

1989

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Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.3044-3050

1990

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New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

Journal of medicinal chemistry, 1989-10, Vol.32 (10), p.2363-2367

1989

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Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates

Journal of medicinal chemistry, 1991-11, Vol.34 (11), p.3176-3181

1991

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Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863

Cancer research (Chicago, Ill.), 1994-01, Vol.54 (1), p.75-84

1994

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Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Journal of medicinal chemistry, 1992-03, Vol.35 (6), p.988-993

1992

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Counterion effects in the preparation of aldehydeabisulfite adducts

Tetrahedron letters, 2013-11, Vol.54 (48), p.6587-6591

2013

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Analysis of neutral N-linked oligosaccharides from antibodies using free-solution capillary electrophoresis in bare fused-silica capillaries

Methods in molecular biology (Clifton, N.J.), 2004, Vol.276, p.137

2004

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Tubulin binding properties of two chiral isomers with 1-deaza-7,8-dihydropteridine structure

Advances in experimental medicine and biology, 1993, Vol.338, p.465

1993

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Data centers achieve a new level of high-tech: Designing solutions for data center clients--whether hyperscale or colocation facilities--requires advanced engineering knowledge

Consulting-specifying engineer, 2020-04, Vol.57 (3), p.58

2020

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Selective reduction of N-oxides to amines: application to drug metabolism

High performance liquid chromatographic enantioseparation development and analytical method characterization of the carboxylate ester of evacetrapib using an immobilized chiral stationary phase with a non-conventional eluent system

Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite

Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Counterion effects in the preparation of aldehyde–bisulfite adducts

Antimitotic agents: structure-activity studies with some pyridine derivatives

A method for the synthesis of 2-amino-4-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-[3H2]

Differential Effects of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl Carbamate Analogs Modified at Position C2 on Tubulin Polymerization, Binding, and Conformational Changes

Kinetics of Association and Dissociation of Two Enantiomers, NSC 613863 (R)-(+) and NSC 613862 (S)-(−) (CI 980), to Tubulin

Tubulin binding of two 1-deaza-7,8-dihydropteridines with different biological properties: Enantiomers NSC 613862 (S)-(-) and NSC 613863 (R)-(+)

Antimitotic agents: ring analogs and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate

Antimitotic agents. Chiral isomers of ethyl 5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7-ylcarbamate

Phosphonate Analogs of Carbocyclic Nucleotides

Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines

New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-carbamate

Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates

Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863

Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Counterion effects in the preparation of aldehydeabisulfite adducts

Analysis of neutral N-linked oligosaccharides from antibodies using free-solution capillary electrophoresis in bare fused-silica capillaries

Tubulin binding properties of two chiral isomers with 1-deaza-7,8-dihydropteridine structure

Data centers achieve a new level of high-tech: Designing solutions for data center clients--whether hyperscale or colocation facilities--requires advanced engineering knowledge

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