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1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydro xy- N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazo lo-[3 ,4- c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (15), p.4141-4147

2006

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Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.4118-4123

2008

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Active Site Mutants of Escherichia coli Dethiobiotin Synthetase: Effects of Mutations on Enzyme Catalytic and Structural Properties

Biochemistry (Easton), 1997-04, Vol.36 (16), p.4751-4760

1997

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Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma

Journal of enzyme inhibition and medicinal chemistry, 2011-08, Vol.26 (4), p.514-526

2011

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BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies

Thrombosis and haemostasis, 2010-08, Vol.104 (2), p.261-269

2010

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Catalysis of the decomposition of hydrogen peroxide by a complex of iron(III) with a synthetic macrocyclic ligand

Journal of the American Chemical Society, 1979-06, Vol.101 (12), p.3232-3240

1979

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Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

Biochemical journal, 2005-06, Vol.388 (Pt 3), p.895-903

2005

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Cyclohexanedione herbicides are selective and potent inhibitors of acetyl-CoA carboxylase from grasses

Plant physiology (Bethesda), 1988-04, Vol.86 (4), p.983-986

1988

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Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (6), p.1604-1607

2013

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The design and synthesis of inhibitors of dethiobiotin synthetase as potential herbicides

Pesticide Science, 1999-03, Vol.55 (3), p.236-247

1999

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Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.67-72

2017

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Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

ACS medicinal chemistry letters, 2014-02, Vol.5 (2), p.188-192

2014

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Determination of the screw sense specificity of bovine liver fructokinase

Biochemistry (Easton), 1985-03, Vol.24 (7), p.1619-1622

1985

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Dethiobiotin Synthetase: The Carbonylation of 7,8-Diaminononanoic Acid Proceeds Regiospecifically via the N7-Carbamate

Biochemistry (Easton), 1995-09, Vol.34 (35), p.10976-10984

1995

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Dethiobiotin Synthetase: The Carbonylation of 7,8-Diaminononanoic Acid Proceeds Regiospecifically via the N7-Carbamate. [Erratum to document cited in CA123:137125]

Biochemistry (Easton), 1995-12, Vol.34 (48), p.15880-15880

1995

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Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate

Archives of biochemistry and biophysics, 2008-07, Vol.475 (1), p.72-79

2008

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5339-5356

2007

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5339-5356

2007

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1247-1261

2017

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Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7125-7137

2016

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Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.217-222

2016

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Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2799-2808

2015

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Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1077-1081

2016

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1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydro xy- N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazo lo-[3 ,4- c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R)-hydroxy- N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Abstract C38: Novel allosteric IDH1 mutant Inhibitors for differentiation therapy of acute myeloid leukemia

Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa

Active Site Mutants of Escherichia coli Dethiobiotin Synthetase: Effects of Mutations on Enzyme Catalytic and Structural Properties

Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma

BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies

Catalysis of the decomposition of hydrogen peroxide by a complex of iron(III) with a synthetic macrocyclic ligand

Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

Cyclohexanedione herbicides are selective and potent inhibitors of acetyl-CoA carboxylase from grasses

Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

The design and synthesis of inhibitors of dethiobiotin synthetase as potential herbicides

Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors

Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

Determination of the screw sense specificity of bovine liver fructokinase

Dethiobiotin Synthetase: The Carbonylation of 7,8-Diaminononanoic Acid Proceeds Regiospecifically via the N7-Carbamate

Dethiobiotin Synthetase: The Carbonylation of 7,8-Diaminononanoic Acid Proceeds Regiospecifically via the N7-Carbamate. [Erratum to document cited in CA123:137125]

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

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