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Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking

Journal of chemical information and modeling, 2011-06, Vol.51 (6), p.1364-1375

2011

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Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities in Vitro and in Vivo

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.3852-3866

2012

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Taking Quinazoline as a General Support-Nog to Design Potent and Selective Kinase Inhibitors: Application to FMS-like Tyrosine Kinase 3

ChemMedChem, 2010-04, Vol.5 (4), p.513-516

2010

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Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6282-6285

2010

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(2-Anilino-4-methyl-thia-zol-5-yl)(4-chloro-phen-yl)methanone

Acta crystallographica. Section E, Structure reports online, 2012-01, Vol.68 (Pt 1), p.o161-o161

2012

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Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway in vitro and inhibits tumor growth in vivo

Cancer letters, 2011-12, Vol.313 (1), p.44-53

2011

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Ethyl 3-amino-4H-thieno[2,3-b]pyridine-2-carboxylate

Acta crystallographica. Section E, Structure reports online, 2009-01, Vol.65 (1), p.o9-o9

2009

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Facile Synthesis of 6-Aryl-3-cyanopyridine-2-(1H)-thiones from Aryl Ketones

Synthetic communications, 2012-05, Vol.42 (10), p.1521-1531

2012

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Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor

Molecular diversity, 2014-05, Vol.18 (2), p.403-409

2014

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SKLB610: A Novel Potential Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibits Angiogenesis and Tumor Growth in Vivo

Cellular physiology and biochemistry, 2011-01, Vol.27 (5), p.565-574

2011

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Pharmacophore Modeling and Hybrid Virtual Screening for the Discovery of Novel IκB Kinase 2 (IKK2) Inhibitors

Journal of biomolecular structure & dynamics, 2011-08, Vol.29 (1), p.165-179

2011

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Weight gain and ghrelin level after olanzapine monotherapy

Progress in neuro-psychopharmacology & biological psychiatry, 2011-03, Vol.35 (2), p.632-635

2011

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The first quantitative ocean remote sensing by using Chinese interferometric imaging radar altimeter onboard TG-2

Acta oceanologica Sinica, 2017-02, Vol.36 (2), p.122-123

2017

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Ethyl 3-(4-methylbenzenesulfonamido)thieno[2,3- b ]pyridine-2-carboxylate

Acta crystallographica. Section E, Structure reports online, 2009-02, Vol.65 (2), p.o257-o257

2009

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4-(4-Nitro-benz-yl)morpholine

Acta crystallographica. Section E, Structure reports online, 2011-04, Vol.67 (Pt 4), p.o754-o754

2011

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Structural Optimization and Structure–Activity Relationships of N 2‑(4-(4-Methylpiperazin-1-yl)phenyl)‑N 8‑phenyl‑9H‑purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10685-10699

2012

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Significant wave height estimation using azimuth cutoff of C-band RADARSAT-2 single-polarization SAR images

Acta oceanologica Sinica, 2015-12, Vol.34 (12), p.93-101

2015

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Optimal Control Research for the Wind Turbine PMSG Chaos Motion

Applied Mechanics and Materials, 2014-03, Vol.543-547 (Vehicle, Mechatronics and Information Technologies II), p.1291-1295

2014

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Adaptive Control of Chaotic Motion in Fractional Order Wind Generators

Advanced materials research, 2014-07, Vol.986-987, p.1039-1042

2014

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Structural Optimization and Structure–Activity Relationships of N 2 -(4-(4-Methylpiperazin-1-yl)phenyl)- N 8 -phenyl-9 H -purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10685-10699

2012

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ChemInform Abstract: Facile Synthesis of 6-Aryl-3-cyanopyridine-2-(1H)-thiones from Aryl Ketones

ChemInform, 2012-09, Vol.43 (38), p.no-no

2012

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Ethyl 3-(4-methyl-benzene-sulfonamido)thieno[2,3-b]pyridine-2-carboxyl-ate

Acta crystallographica. Section E, Structure reports online, 2009-01, Vol.65 (Pt 2), p.o257-o257

2009

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Nested case-control analysis with general additive-multiplicative hazard models

Applied Mathematics-A Journal of Chinese Universities, 2012-06, Vol.27 (2), p.159-168

2012

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Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway invitro and inhibits tumor growth invivo

Cancer letters, 2011-12, Vol.313 (1), p.44-53

2011

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TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

Cell research, 2016-09, Vol.26 (9), p.1048-1061

2016

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Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking

Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities in Vitro and in Vivo

Taking Quinazoline as a General Support-Nog to Design Potent and Selective Kinase Inhibitors: Application to FMS-like Tyrosine Kinase 3

Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation

(2-Anilino-4-methyl-thia-zol-5-yl)(4-chloro-phen-yl)methanone

Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway in vitro and inhibits tumor growth in vivo

Ethyl 3-amino-4H-thieno[2,3-b]pyridine-2-carboxylate

Facile Synthesis of 6-Aryl-3-cyanopyridine-2-(1H)-thiones from Aryl Ketones

Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor

SKLB610: A Novel Potential Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibits Angiogenesis and Tumor Growth in Vivo

Pharmacophore Modeling and Hybrid Virtual Screening for the Discovery of Novel IκB Kinase 2 (IKK2) Inhibitors

Weight gain and ghrelin level after olanzapine monotherapy

The first quantitative ocean remote sensing by using Chinese interferometric imaging radar altimeter onboard TG-2

Ethyl 3-(4-methylbenzenesulfonamido)thieno[2,3- b ]pyridine-2-carboxylate

4-(4-Nitro-benz-yl)morpholine

Structural Optimization and Structure–Activity Relationships of N 2‑(4-(4-Methylpiperazin-1-yl)phenyl)‑N 8‑phenyl‑9H‑purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

Significant wave height estimation using azimuth cutoff of C-band RADARSAT-2 single-polarization SAR images

Optimal Control Research for the Wind Turbine PMSG Chaos Motion

Adaptive Control of Chaotic Motion in Fractional Order Wind Generators

Structural Optimization and Structure–Activity Relationships of N 2 -(4-(4-Methylpiperazin-1-yl)phenyl)- N 8 -phenyl-9 H -purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

ChemInform Abstract: Facile Synthesis of 6-Aryl-3-cyanopyridine-2-(1H)-thiones from Aryl Ketones

Ethyl 3-(4-methyl-benzene-sulfonamido)thieno[2,3-b]pyridine-2-carboxyl-ate

Nested case-control analysis with general additive-multiplicative hazard models

Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway invitro and inhibits tumor growth invivo

TALEN-based generation of a cynomolgus monkey disease model for human microcephaly

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