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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

Diabetes (New York, N.Y.), 2013-06, Vol.62 (6), p.1876-1887

2013

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Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis

Gastroenterology (New York, N.Y. 1943), 2021-07, Vol.161 (1), p.271-286.e11

2021

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A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway

The Journal of biological chemistry, 2006-05, Vol.281 (21), p.15013-15020

2006

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Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

Molecular and cellular biology, 2016-11, Vol.36 (21), p.2715-2727

2016

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Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

Acta pharmaceutica Sinica. B, 2024-03, Vol.14 (3), p.1241-1256

2024

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Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1369-1377

2006

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Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma

Hepatology communications, 2022-05, Vol.6 (5), p.1123-1139

2022

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Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization

Hepatology (Baltimore, Md.), 2008-04, Vol.47 (4), p.1331-1342

2008

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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

Hepatology (Baltimore, Md.), 2007-02, Vol.45 (2), p.422-432

2007

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A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification

Molecular pharmacology, 2004-02, Vol.65 (2), p.292-300

2004

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Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

Endocrinology (Philadelphia), 2010-12, Vol.151 (12), p.5721-5729

2010

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Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis

Hepatology communications, 2020-11, Vol.4 (11), p.1664-1679

2020

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Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Hepatology (Baltimore, Md.), 2005, Vol.41 (1), p.168-176

2005

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Transgenic overexpression of steroid sulfatase alleviates cholestasis

Liver research, 2017-06, Vol.1 (1), p.63-69

2017

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ERINA Is an Estrogen-Responsive LncRNA That Drives Breast Cancer through the E2F1/RB1 Pathway

Cancer research (Chicago, Ill.), 2020-10, Vol.80 (20), p.4399-4413

2020

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Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

Hepatology (Baltimore, Md.), 2005-03, Vol.41 (3), p.497-505

2005

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CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α

Molecular endocrinology (Baltimore, Md.), 2015-11, Vol.29 (11), p.1558-1570

2015

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Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice

Gastroenterology (New York, N.Y. 1943), 2019-09, Vol.157 (3), p.793-806.e14

2019

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Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock–Induced Liver Injury

Hepatology (Baltimore, Md.), 2019-09, Vol.70 (3), p.995-1010

2019

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Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

Gastroenterology (New York, N.Y. 1943), 2008-02, Vol.134 (2), p.556-567.e1

2008

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PAPSS2 ablation prevents acetaminophen‐induced hepatotoxicity in mice

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure

Gastroenterology (New York, N.Y. 1943), 2022-04, Vol.162 (4), p.1226-1241

2022

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Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens

The Journal of biological chemistry, 2023-03, Vol.299 (3), p.103026-103026, Article 103026

2023

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Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR

Endocrinology (Philadelphia), 2022-07, Vol.163 (7), p.1

2022

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Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis

Endocrinology (Philadelphia), 2018-09, Vol.159 (9), p.3365-3377

2018

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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis

A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway

Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats

Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma

Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification

Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Transgenic overexpression of steroid sulfatase alleviates cholestasis

ERINA Is an Estrogen-Responsive LncRNA That Drives Breast Cancer through the E2F1/RB1 Pathway

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α

Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock–Induced Liver Injury

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

PAPSS2 ablation prevents acetaminophen‐induced hepatotoxicity in mice

Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure

Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens

Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR

Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis

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