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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

ACS medicinal chemistry letters, 2016-02, Vol.7 (2), p.162-166

2016

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Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

The FASEB journal, 2011-07, Vol.25 (7), p.2234-2244

2011

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An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer

PloS one, 2012-01, Vol.7 (1), p.e29615-e29615

2012

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Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs

Nature biomedical engineering, 2018-11, Vol.2 (11), p.822

2018

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Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

Journal of the American Chemical Society, 2021-03, Vol.143 (12), p.4714-4724

2021

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Correction to Discovery of the Hemifumarate and (α‑l‑Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.3237-3237

2018

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A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1954-1965

2007

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Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.10-18

1996

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Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4069-4072

2010

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Potent, selective pyrimidinetrione-based inhibitors of MMP-13

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5822-5826

2006

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Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1807-1810

2005

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Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

Bioorganic & medicinal chemistry, 2008-05, Vol.18 (9), p.3000-3006

2008

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Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3389-3395

2004

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Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6529-6534

2007

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Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2331-2336

2003

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The identification of orally bioavailable thrombopoietin agonists

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1428-1430

2009

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Pyrimidine benzamide-based thrombopoietin receptor agonists

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5447-5454

2007

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Synthesis of 4(5)-acyl-, 1-substituted 5-acyl- and 1-substituted 4-acyl-1H-imidazoles from 4-aminoisoxazoles

Journal of organic chemistry, 1987-06, Vol.52 (13), p.2714-2726

Reiter, Lawrence A

1987

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Amide-Assisted Hydrolysis of β-Carboxamido-Substituted Phosphinic Acid Esters

Journal of organic chemistry, 1997-05, Vol.62 (9), p.2808-2812

1997

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Difluoroketones as inhibitors of matrix metalloprotease-13

Bioorganic & medicinal chemistry letters, 2000-07, Vol.10 (14), p.1581-1584

2000

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(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3197-3199

1994

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Studies on the molybdenum cofactor. An unequivocal total synthesis of (.+-.)-urothione

Journal of the American Chemical Society, 1989, Vol.111 (1), p.285-291

1989

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Involvement of Transmembrane Helix Dimerization and Rotation in Signaling by the Thrombopoietin Receptor

Biophysical journal, 2010-01, Vol.98 (3), p.420a-420a

2010

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The Synthesis of an Aminohexyl-containing Analog of the Chromanol Leukotriene B4 Receptor Antagonist CP-195543: A Scaffold for the Preparation of Derivatized Analogs

Heterocycles, 2000-08, Vol.53 (8), p.1713

2000

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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs

Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

Correction to Discovery of the Hemifumarate and (α‑l‑Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group

A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif

Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group

Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14

Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3

The identification of orally bioavailable thrombopoietin agonists

Pyrimidine benzamide-based thrombopoietin receptor agonists

Synthesis of 4(5)-acyl-, 1-substituted 5-acyl- and 1-substituted 4-acyl-1H-imidazoles from 4-aminoisoxazoles

Amide-Assisted Hydrolysis of β-Carboxamido-Substituted Phosphinic Acid Esters

Difluoroketones as inhibitors of matrix metalloprotease-13

Abstract LB-062: Development of macromolecular prodrugs of BET-bromodomain inhibitors with superior anti-tumor efficacy that are T-cell sparing and devoid of systemic toxicity

(+)-1-(3S,4R)-[3-(4-Phenylbenzyl)-4- hydroxychroman-7-yl]cyclopentane Carboxylic Acid, a Highly Potent, Selective Leukotriene B4 Antagonist with Oral Activity in the Murine Collagen-Induced Arthritis Model

Studies on the molybdenum cofactor. An unequivocal total synthesis of (.+-.)-urothione

Involvement of Transmembrane Helix Dimerization and Rotation in Signaling by the Thrombopoietin Receptor

The Synthesis of an Aminohexyl-containing Analog of the Chromanol Leukotriene B4 Receptor Antagonist CP-195543: A Scaffold for the Preparation of Derivatized Analogs

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