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Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

Toxicology and applied pharmacology, 2010-04, Vol.244 (1), p.57-65

2010

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Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

Toxicological sciences, 2009-10, Vol.111 (2), p.238-246

2009

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Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

Biochemical pharmacology, 2009-04, Vol.77 (7), p.1273-1282

2009

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Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9

Free radical research, 2020-07, Vol.54 (7), p.525-534

2020

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Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Journal of the American Society of Nephrology, 2012-10, Vol.23 (10), p.1663-1673

2012

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Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

Radiation research, 2014-05, Vol.181 (5), p.512

2014

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CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

Toxicology and applied pharmacology, 2009-04, Vol.236 (1), p.109-114

2009

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Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice

The Journal of pharmacology and experimental therapeutics, 2010-04, Vol.333 (1), p.140-151

2010

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Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis

Journal of biochemical and molecular toxicology, 2020-09, Vol.34 (9), p.e22526-n/a

2020

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Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

Clinical and translational science, 2021-01, Vol.14 (1), p.299-309

2021

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Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

Toxicological sciences, 2009-05, Vol.109 (1), p.31-40

2009

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The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

Redox biology, 2013-01, Vol.1 (1), p.527-531

2013

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Increased Nrf2 Activation in Livers from Keap1-Knockdown Mice Increases Expression of Cytoprotective Genes that Detoxify Electrophiles more than those that Detoxify Reactive Oxygen Species

Toxicological sciences, 2009-03, Vol.108 (1), p.35-47

2009

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The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

Xenobiotica, 2014-06, Vol.44 (6), p.570-578

2014

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Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

American journal of nephrology, 2014-01, Vol.39 (6), p.499-508

2014

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The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

Free radical biology & medicine, 2017-07, Vol.108, p.585-594

2017

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The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury

Toxicological sciences, 2016-01, Vol.149 (1), p.111-120

2016

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A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (6), p.126967, Article 126967

2020

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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Drug design, development and therapy, 2019-01, Vol.13, p.1259-1270

2019

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Bortezomib: A therapeutic resource for the veterinary oncologist?

The veterinary journal (1997), 2013-12, Vol.198 (3), p.543-544

Reisman, Scott A.

2013

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GABAB receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants

Brain research, 2006-01, Vol.1068 (1), p.109-117

2006

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Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Archives of Dermatological Research, 2014-07, Vol.306 (5), p.447-454

2014

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Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

OncoTargets and therapy, 2017-01, Vol.10, p.4239-4250

2017

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Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity

Toxicology and applied pharmacology, 2008-09, Vol.231 (3), p.364-373

2008

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Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BMC dermatology, 2015-07, Vol.15 (1), p.10, Article 10

2015

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Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney

Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice

Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis

Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

Increased Nrf2 Activation in Livers from Keap1-Knockdown Mice Increases Expression of Cytoprotective Genes that Detoxify Electrophiles more than those that Detoxify Reactive Oxygen Species

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury

A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Bortezomib: A therapeutic resource for the veterinary oncologist?

GABAB receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants

Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

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