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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8584-8607

2020

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6190-6213

2019

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Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.12895-12924

2022

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DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions

Synlett, 2011-10, Vol.2011 (16), p.2392-2396

2011

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T reg Trafficking into the Tumor Microenvironment

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6190-6213

2019

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Microwave-Assisted Esterification: A Discovery-Based Microscale Laboratory Experiment

Journal of chemical education, 2014-10, Vol.91 (10), p.1706-1709

2014

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Allyl Transfer to Aldehydes and Ketones by Brønsted Acid Activation of Allyl and Crotyl 1,3,2-Dioxazaborolidines

Organic letters, 2010-11, Vol.12 (21), p.4892-4895

2010

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Abstract 4752: EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4752-4752

2018

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Abstract 4600: Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4600-4600

2017

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Abstract 4290: Potent and selective next generation inhibitors of indoleamine-2,3-dioxygenase (IDO1) for the treatment of cancer

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4290-4290

2015

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Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers

Synthetic communications, 2008-02, Vol.38 (5), p.656-665

2008

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ChemInform Abstract: Allyl Transfer to Aldehydes and Ketones by Broensted Acid Activation of Allyl and Crotyl 1,3,2-Dioxazaborolidines

ChemInform, 2011-03, Vol.42 (9), p.no-no

2011

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ChemInform Abstract: Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers

ChemInform, 2008-08, Vol.39 (32), p.no-no

2008

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Randomized Trial of Occlusive Wrap for Heat Loss Prevention in Preterm Infants

The Journal of pediatrics, 2015-02, Vol.166 (2), p.262-268.e2

2015

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Attitudes toward advance care planning among persons with dementia and their caregivers

International psychogeriatrics, 2020-05, Vol.32 (5), p.585-599

2020

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1015-P: Disparities in CGM Uptake and Sustained Use among Youth with Type 1 Diabetes

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Fluid balance in critically ill children with acute lung injury

Critical care medicine, 2012-10, Vol.40 (10), p.2883-2889

2012

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Sperm Banking for Adolescent and Young Adult Cancer Patients: Sperm Quality, Patient, and Parent Perspectives

Pediatric blood & cancer, 2008-03, Vol.50 (3), p.594-598

2008

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Author Correction: Discovery of 42 genome-wide significant loci associated with dyslexia

Nature genetics, 2023-03, Vol.55 (3), p.520-520

2023

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Health-related quality of life of adolescent and young adult survivors of childhood brain tumors

Psycho-oncology (Chichester, England), 2015-07, Vol.24 (7), p.804-811

2015

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Pharmacokinetics, Safety, and 48-Week Efficacy of Oral Raltegravir in HIV-1-Infected Children Aged 2 Through 18 Years

Clinical infectious diseases, 2014-02, Vol.58 (3), p.413-422

2014

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Promising Practices in Vocational Services for the Community Reintegration of Returning Veterans: The Individual Placement and Support Model and Beyond

Psychological services, 2018-05, Vol.15 (2), p.191-199

2018

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Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis

The American journal of pathology, 1995-12, Vol.147 (6), p.1715-1727

1995

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A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology

Cytopathology (Oxford), 2015-06, Vol.26 (3), p.178-187

2015

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Responsiveness of the EQ-5D to HADS-identified anxiety and depression

Journal of evaluation in clinical practice, 2009-10, Vol.15 (5), p.820-825

Whynes, David K.

2009

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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment

Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T reg Trafficking into the Tumor Microenvironment

Microwave-Assisted Esterification: A Discovery-Based Microscale Laboratory Experiment

Allyl Transfer to Aldehydes and Ketones by Brønsted Acid Activation of Allyl and Crotyl 1,3,2-Dioxazaborolidines

Abstract 4752: EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists

Abstract 4600: Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)

Abstract 4290: Potent and selective next generation inhibitors of indoleamine-2,3-dioxygenase (IDO1) for the treatment of cancer

Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers

ChemInform Abstract: Allyl Transfer to Aldehydes and Ketones by Broensted Acid Activation of Allyl and Crotyl 1,3,2-Dioxazaborolidines

ChemInform Abstract: Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers

Randomized Trial of Occlusive Wrap for Heat Loss Prevention in Preterm Infants

Attitudes toward advance care planning among persons with dementia and their caregivers

1015-P: Disparities in CGM Uptake and Sustained Use among Youth with Type 1 Diabetes

Fluid balance in critically ill children with acute lung injury

Sperm Banking for Adolescent and Young Adult Cancer Patients: Sperm Quality, Patient, and Parent Perspectives

Author Correction: Discovery of 42 genome-wide significant loci associated with dyslexia

Health-related quality of life of adolescent and young adult survivors of childhood brain tumors

Pharmacokinetics, Safety, and 48-Week Efficacy of Oral Raltegravir in HIV-1-Infected Children Aged 2 Through 18 Years

Promising Practices in Vocational Services for the Community Reintegration of Returning Veterans: The Individual Placement and Support Model and Beyond

Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis

A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology

Responsiveness of the EQ-5D to HADS-identified anxiety and depression

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