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The multicellular tumor spheroid model for high-throughput cancer drug discovery

Expert opinion on drug discovery, 2012-09, Vol.7 (9), p.819-830

2012

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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9806-9811

2013

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Discovery of Novel Small Molecule Inhibitors of Cardiac Hypertrophy Using High Throughput, High Content Imaging

Journal of molecular and cellular cardiology, 2016-08, Vol.97, p.106-113

2016

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Active Metabolite of Aeruginascin (4-Hydroxy‑N,N,N‑trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

ACS omega, 2020-07, Vol.5 (27), p.16940-16943

2020

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ClpS, a Substrate Modulator of the ClpAP Machine

Molecular cell, 2002-03, Vol.9 (3), p.673-683

2002

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Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

Nature (London), 1999-09, Vol.401 (6748), p.90-93

1999

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A Small-Molecule Inhibitor of Hepatitis C Virus Infectivity

Antimicrobial Agents and Chemotherapy, 2014-01, Vol.58 (1), p.386-396

2014

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Chromophore Formation in Green Fluorescent Protein

Biochemistry (Easton), 1997-06, Vol.36 (22), p.6786-6791

1997

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BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

Journal of molecular and cellular cardiology, 2013-10, Vol.63, p.175-179

2013

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Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics

The Journal of biological chemistry, 2006-10, Vol.281 (43), p.32784-32795

2006

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ClpA Mediates Directional Translocation of Substrate Proteins into the ClpP Protease

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (7), p.3768-3772

2001

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A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer

Journal of biomolecular screening, 2012-10, Vol.17 (9), p.1211-1220

2012

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Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition

Marine drugs, 2011, Vol.9 (11), p.2397-2408

2011

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Roles of the N-domains of the ClpA Unfoldase in Binding Substrate Proteins and in Stable Complex Formation with the ClpP Protease

The Journal of biological chemistry, 2005-12, Vol.280 (49), p.40838-40844

2005

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Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6544-6548

2005

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Live Multicellular Tumor Spheroid Models For High-Content Imaging and Screening In Cancer Drug Discovery

Current chemical genomics and translational medicine, 2014, Vol.8 (1), p.27-35

2014

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Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1

Biochimica et biophysica acta, 2009-05, Vol.1789 (5), p.422-431

2009

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Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor

Journal of biomolecular screening, 2011-08, Vol.16 (7), p.724-733

2011

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High-throughput determination of mode of inhibition in lead identification and optimization

Journal of biomolecular screening, 2007-03, Vol.12 (2), p.220-228

2007

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GroEL Binds to and Unfolds Rhodanese Posttranslationally

The Journal of biological chemistry, 1996-03, Vol.271 (12), p.7212-7217

1996

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Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase II[alpha] Activity Through ATP-Competitive Inhibition

Marine drugs, 2011-11, Vol.9 (11), p.2397

2011

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Structure, function and pharmacology of human itch GPCRs

Nature (London), 2021-12, Vol.600 (7887), p.170-175

2021

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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Nature chemical biology, 2020-08, Vol.16 (8), p.841-849

2020

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Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Nature communications, 2018-02, Vol.9 (1), p.794-12, Article 794

2018

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In Vivo Whole Animal Fluorescence Imaging of a Microparticle-Based Oral Vaccine Containing (CuInSe x S2–x )/ZnS Core/Shell Quantum Dots

Nano letters, 2013-09, Vol.13 (9), p.4294-4298

2013

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The multicellular tumor spheroid model for high-throughput cancer drug discovery

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy

Discovery of Novel Small Molecule Inhibitors of Cardiac Hypertrophy Using High Throughput, High Content Imaging

Active Metabolite of Aeruginascin (4-Hydroxy‑N,N,N‑trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

ClpS, a Substrate Modulator of the ClpAP Machine

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

A Small-Molecule Inhibitor of Hepatitis C Virus Infectivity

Chromophore Formation in Green Fluorescent Protein

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics

ClpA Mediates Directional Translocation of Substrate Proteins into the ClpP Protease

A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition

Roles of the N-domains of the ClpA Unfoldase in Binding Substrate Proteins and in Stable Complex Formation with the ClpP Protease

Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics

Live Multicellular Tumor Spheroid Models For High-Content Imaging and Screening In Cancer Drug Discovery

Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1

Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor

High-throughput determination of mode of inhibition in lead identification and optimization

GroEL Binds to and Unfolds Rhodanese Posttranslationally

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase II[alpha] Activity Through ATP-Competitive Inhibition

Structure, function and pharmacology of human itch GPCRs

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

In Vivo Whole Animal Fluorescence Imaging of a Microparticle-Based Oral Vaccine Containing (CuInSe x S2–x )/ZnS Core/Shell Quantum Dots

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