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Open innovation in early drug discovery: roadmaps and roadblocks

Drug discovery today, 2016-05, Vol.21 (5), p.779-788

2016

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Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes

PloS one, 2014-02, Vol.9 (2), p.e90031-e90031

2014

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Development of a High-Throughput Screen for Inhibitors of Epstein-Barr Virus EBNA1

Journal of biomolecular screening, 2010-10, Vol.15 (9), p.1107-1115

2010

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New informatics and automated infrastructure to accelerate new leads discovery by high throughput screening (HTS)

Combinatorial chemistry & high throughput screening, 2013-03, Vol.16 (3), p.180

2013

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Opening the lead generation toolbox

Nature reviews. Drug discovery, 2014-01, Vol.13 (1), p.3-4

2014

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Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor

Proceedings of the National Academy of Sciences - PNAS, 2023-08, Vol.120 (31), p.1

2023

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Identification of a β-arrestin-biased negative allosteric modulator for the β 2 -adrenergic receptor

Proceedings of the National Academy of Sciences - PNAS, 2023-08, Vol.120 (31), p.e2302668120

2023

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Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors

ACS chemical biology, 2014-07, Vol.9 (7), p.1603-1612

2014

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Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes

Endocrinology (Philadelphia), 1997-09, Vol.138 (9), p.3779-3786

1997

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Development and Validation of a Universal High-Throughput UDP-Glycosyltransferase Assay with a Time-Resolved FRET Signal

Assay and drug development technologies, 2016-05, Vol.14 (4), p.240

2016

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Preclinical study of the long‐range safety and anti‐inflammatory effects of high‐dose oral meglumine

Journal of cellular biochemistry, 2019-07, Vol.120 (7), p.12051-12062

2019

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Abstract 3803: Development of genetic and chemical tools for understanding the recruitment of DOT1L in MLL-fusion driven leukemia and normal hematopoiesis

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3803-3803

2016

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A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay

Journal of biomolecular screening, 2015-12, Vol.20 (10), p.1294-1299

2015

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8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (3), p.509-514

1994

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Systemic analgesic activity and .delta.-opioid selectivity in [2,6-dimethyl-Tyr1, D-Pen2, D-Pen5]enkephalin

Journal of medicinal chemistry, 1992-02, Vol.35 (4), p.684-687

1992

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A Cell-Based High-Throughput Screen For Novel Inducers Of Fetal Hemoglobin For Treatment Of Sickle Cell Disease, Cooley's Anemia and β-Thalassemias

Blood, 2013-11, Vol.122 (21), p.925-925

2013

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N-Substituted dibenzoxazepines as analgesic PGE2 antagonists

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3293-3299

1993

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Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

Chemistry & biology, 2012-04, Vol.19 (4), p.518-528

2012

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8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE 2 antagonist and analgesic

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (3), p.509-514

1994

Volltextzugriff (PDF)

CHARACTERIZATION OF OPIATE RECEPTOR HETEROGENEITY USING AFFINITY LIGANDS AND PHOSPHOLIPASE A(,2)

REICHMAN, MELVIN

1985

Volltextzugriff (PDF)

Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.2928-2938

1992

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Approaches to automation for high‐throughput screening

Laboratory robotics and automation, 1996, Vol.8 (5), p.267-276

1996

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Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3

Chemistry & biology, 1999-05, Vol.6 (5), p.265-275

1999

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Acetylcholine Releases Prostaglandins from Brain Slices Incubated In Vitro

Journal of neurochemistry, 1987-10, Vol.49 (4), p.1216-1221

1987

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The biochemical and behavioral effects of phospholipase A 2 and morphine microinjections in the periaqueductal gray of the rat

Life sciences (1973), 1985, Vol.36 (6), p.515-523

1985

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Open innovation in early drug discovery: roadmaps and roadblocks

Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes

Development of a High-Throughput Screen for Inhibitors of Epstein-Barr Virus EBNA1

New informatics and automated infrastructure to accelerate new leads discovery by high throughput screening (HTS)

Opening the lead generation toolbox

Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor

Identification of a β-arrestin-biased negative allosteric modulator for the β 2 -adrenergic receptor

Identification and Characterization of Small Molecule Human Papillomavirus E6 Inhibitors

Androgen Receptor-Mediated Antagonism of Estrogen-Dependent Low Density Lipoprotein Receptor Transcription in Cultured Hepatocytes

Development and Validation of a Universal High-Throughput UDP-Glycosyltransferase Assay with a Time-Resolved FRET Signal

Preclinical study of the long‐range safety and anti‐inflammatory effects of high‐dose oral meglumine

Abstract 3803: Development of genetic and chemical tools for understanding the recruitment of DOT1L in MLL-fusion driven leukemia and normal hematopoiesis

A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic

Systemic analgesic activity and .delta.-opioid selectivity in [2,6-dimethyl-Tyr1, D-Pen2, D-Pen5]enkephalin

A Cell-Based High-Throughput Screen For Novel Inducers Of Fetal Hemoglobin For Treatment Of Sickle Cell Disease, Cooley's Anemia and β-Thalassemias

N-Substituted dibenzoxazepines as analgesic PGE2 antagonists

Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE 2 antagonist and analgesic

CHARACTERIZATION OF OPIATE RECEPTOR HETEROGENEITY USING AFFINITY LIGANDS AND PHOSPHOLIPASE A(,2)

Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions

Approaches to automation for high‐throughput screening

Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3

Acetylcholine Releases Prostaglandins from Brain Slices Incubated In Vitro

The biochemical and behavioral effects of phospholipase A 2 and morphine microinjections in the periaqueductal gray of the rat

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