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Development and characterization of canine‐specific computational models to predict pulsatile arterial hemodynamics and ventricular‐arterial coupling

Physiological reports, 2023-06, Vol.11 (11), p.e15731-n/a

2023

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Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Hepatology (Baltimore, Md.), 2016-11, Vol.64 (5), p.1430-1441

2016

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QT interval correction assessment in the anesthetized guinea pig

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.52-61

2015

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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

Channels (Austin, Tex.), 2022-12, Vol.16 (1), p.230-243

2022

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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.107-114

2016

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Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor

Neuroscience research, 2009, Vol.63 (1), p.10-16

2009

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Long term assessment of blood pressure transducer drift in rhesus monkeys chronically instrumented with telemetry implants

Journal of pharmacological and toxicological methods, 2009-01, Vol.59 (1), p.35-38

2009

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Getting more from blood pressure signals: Use of pulse wave analysis (PWA) to enable greater insight to compound-dependent hemodynamic effects

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Development and characterization of a nerve conduction model in anesthetized non-human primates as a tool to assess compound-dependent peripheral nervous system risk

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections

Journal of pharmacological and toxicological methods, 2007-11, Vol.56 (3), p.339-343

2007

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Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106817, Article 106817

2020

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3400-3418

2024

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Measurement of heart rate variability (HRV) and spontaneous baroreflex sensitivity (sBRS) provides valuable information on compound-dependent cardiovascular effects to enhance safety risk assessment

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor

Toxicological sciences, 2022-01, Vol.185 (2), p.170-183

2022

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Evaluation of clinically-relevant proarrhythmic ECG biomarkers in conscious beagle dogs using a newly developed multiple lead ECG telemetry implant

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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A Preclinical Paradigm to Assess the Potential Risk and In Vivo Mechanism(s) Responsible for the Bradyarrhythmia Observed in Hepatitis-C Virus (HCV) Infected Patients Treated with Direct-Acting Antivirals (DAAs) and Amiodarone

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.214-214

2017

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Characterization and Optimization of Pulmonary Function Assessment Methodologies in Restrained Non-rodent Models

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.234-234

2017

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Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.182-182

2015

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QT interval correction assessment in the ketamine/xylazine-anesthetized guinea pig model

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.187-187

2015

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Use of non-human primate models to enable early investigational cardiovascular de-risking

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.196-196

2012

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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3970-3975

2011

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Contribution of T‐type Ca2+ channels to blood pressure regulation in genetically hypertensive rats

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113505-113505, Article 113505

2023

Volltextzugriff (PDF)

Making Heads or Tails of the Large Mammalian Sinoatrial Node Micro-Organization

Circulation. Arrhythmia and electrophysiology, 2021-12, Vol.14 (12), p.e010465-e010465

2021

Volltextzugriff (PDF)

Early Identification of Family Physicians Using Qualitative Admissions Data

Family medicine, 2023-04, Vol.55 (4), p.245-252

2023

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Development and characterization of canine‐specific computational models to predict pulsatile arterial hemodynamics and ventricular‐arterial coupling

Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

QT interval correction assessment in the anesthetized guinea pig

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve

Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor

Long term assessment of blood pressure transducer drift in rhesus monkeys chronically instrumented with telemetry implants

Getting more from blood pressure signals: Use of pulse wave analysis (PWA) to enable greater insight to compound-dependent hemodynamic effects

Development and characterization of a nerve conduction model in anesthetized non-human primates as a tool to assess compound-dependent peripheral nervous system risk

An improved automated method to quantitate infarct volume in triphenyltetrazolium stained rat brain sections

Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models

Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration

Measurement of heart rate variability (HRV) and spontaneous baroreflex sensitivity (sBRS) provides valuable information on compound-dependent cardiovascular effects to enhance safety risk assessment

Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor

Evaluation of clinically-relevant proarrhythmic ECG biomarkers in conscious beagle dogs using a newly developed multiple lead ECG telemetry implant

A Preclinical Paradigm to Assess the Potential Risk and In Vivo Mechanism(s) Responsible for the Bradyarrhythmia Observed in Hepatitis-C Virus (HCV) Infected Patients Treated with Direct-Acting Antivirals (DAAs) and Amiodarone

Characterization and Optimization of Pulmonary Function Assessment Methodologies in Restrained Non-rodent Models

Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats

QT interval correction assessment in the ketamine/xylazine-anesthetized guinea pig model

Use of non-human primate models to enable early investigational cardiovascular de-risking

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Contribution of T‐type Ca2+ channels to blood pressure regulation in genetically hypertensive rats

The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain

Making Heads or Tails of the Large Mammalian Sinoatrial Node Micro-Organization

Early Identification of Family Physicians Using Qualitative Admissions Data

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