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Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

Cell reports (Cambridge), 2018-03, Vol.22 (11), p.2937-2950

2018

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Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

Molecular cell, 2011-10, Vol.44 (2), p.265-278

2011

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A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

Blood, 2014-08, Vol.124 (7), p.999-1009

2014

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A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application

International journal of molecular sciences, 2022-02, Vol.23 (5), p.2441

2022

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Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease

International journal of molecular sciences, 2022-06, Vol.23 (12), p.6400

2022

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Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens

FEMS microbiology reviews, 2004-02, Vol.28 (1), p.101-112

2004

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The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes

Microbiology (Society for General Microbiology), 2011-05, Vol.157 (Pt 5), p.1481-1488

2011

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Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

Frontiers in immunology, 2020-12, Vol.11, p.600033-600033

2020

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Killing activity of neutrophils is mediated through activation of proteases by K + flux

Nature (London), 2002-03, Vol.416 (6878), p.291-297

2002

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Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung

The Journal of immunology (1950), 2014-03, Vol.192 (5), p.2418-2431

2014

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Superoxide Production in Galleria mellonella Hemocytes: Identification of Proteins Homologous to the NADPH Oxidase Complex of Human Neutrophils

Infection and Immunity, 2005-07, Vol.73 (7), p.4161-4170

2005

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Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

Medicina (Kaunas, Lithuania), 2021-08, Vol.57 (8), p.814

2021

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Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis

Frontiers in pharmacology, 2020-07, Vol.11, p.1098-1098

2020

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Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

TheScientificWorld, 2012-01, Vol.2012, p.465230-11

2012

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Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis

Expert review of respiratory medicine, 2022-01, Vol.16 (1), p.43-56

2022

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Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin

Journal of medical microbiology, 2010-06, Vol.59 (6), p.625-633

2010

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Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

EBioMedicine, 2022-03, Vol.77, p.103894-103894, Article 103894

2022

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C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

Biomedicines, 2021-12, Vol.9 (12), p.1925

2021

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In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin

ERJ open research, 2021-10, Vol.7 (4)

2021

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The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency

Annals of the American Thoracic Society, 2016-08, Vol.13 Suppl 4 (Supplement_4), p.S297-S304

2016

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Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways

The Journal of immunology (1950), 2011-03, Vol.186 (5), p.2897-2909

2011

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The Role and Importance of Glycosylation of Acute Phase Proteins with Focus on Alpha‑1 Antitrypsin in Acute and Chronic Inflammatory Conditions

Journal of proteome research, 2014-07, Vol.13 (7), p.3131-3143

2014

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The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity

Science translational medicine, 2014-01, Vol.6 (217), p.217ra1

2014

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Trikafta Rescues CFTR and Lowers Monocyte P2X7R-induced Inflammasome Activation in Cystic Fibrosis

American journal of respiratory and critical care medicine, 2022-04, Vol.205 (7), p.783-794

2022

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Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis

American journal of respiratory and critical care medicine, 2019-12, Vol.200 (11), p.1381-1391

2019

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Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application

Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease

Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens

The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

Killing activity of neutrophils is mediated through activation of proteases by K + flux

Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung

Superoxide Production in Galleria mellonella Hemocytes: Identification of Proteins Homologous to the NADPH Oxidase Complex of Human Neutrophils

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis

Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis

Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin

Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin

The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways

The Role and Importance of Glycosylation of Acute Phase Proteins with Focus on Alpha‑1 Antitrypsin in Acute and Chronic Inflammatory Conditions

The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity

Trikafta Rescues CFTR and Lowers Monocyte P2X7R-induced Inflammasome Activation in Cystic Fibrosis

Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis

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