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Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

PLoS computational biology, 2022-02, Vol.18 (2), p.e1009855-e1009855

2022

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A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

Nature communications, 2022-06, Vol.13 (1), p.3165-3165, Article 3165

2022

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Protein design algorithms predict viable resistance to an experimental antifolate

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.749-754

2015

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Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

Molecules (Basel, Switzerland), 2022-02, Vol.27 (5), p.1518

2022

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Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins

Journal of antibiotics, 2021-06, Vol.74 (6), p.381-396

2021

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Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Journal of the American Chemical Society, 2015-07, Vol.137 (28), p.8983-8990

2015

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Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus

Proceedings of the National Academy of Sciences - PNAS, 2024-01, Vol.121 (2), p.e2314101120-e2314101120

2024

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Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6493-6500

2016

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MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates

Cell chemical biology, 2016-12, Vol.23 (12), p.1458-1467

2016

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Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.1000-1020

2021

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OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1529, p.291

2017

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Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria

ACS infectious diseases, 2021-11, Vol.7 (11), p.3009-3024

2021

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Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

ACS infectious diseases, 2020-03, Vol.6 (3), p.467-478

2020

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Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery

Future microbiology, 2015-11, Vol.10 (11), p.1727-1733

2015

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Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

ACS infectious diseases, 2019-11, Vol.5 (11), p.1896-1906

2019

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Non-racemic Antifolates Stereo-selectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Journal of the American Chemical Society, 2015-07, Vol.137 (28), p.8983-8990

2015

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1233. Identification of Novel Inhibitors of Clostridioides difficile Enoyl-Reductase II (FabK) by High-Throughput Virtual and Experimental Screening

Open forum infectious diseases, 2020-12, Vol.7 (Supplement_1), p.S636-S636

2020

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Single Molecule Fluorescence Studies of Antibody Structure

Biophysical journal, 2011-02, Vol.100 (3), p.376a-376a

2011

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Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

ACS infectious diseases, 2019-10, Vol.5 (11), p.1896-1906

2019

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Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting

Journal of clinical microbiology, 2021-11, Vol.59 (12), p.e0131621-e0131621

2021

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A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space

Cell, 2019-03, Vol.176 (6), p.1393-1406.e16

2019

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Feasibility of Patient Reporting of Symptomatic Adverse Events via the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in a Chemoradiotherapy Cooperative Group Multicenter Clinical Trial

International journal of radiation oncology, biology, physics, 2017-06, Vol.98 (2), p.409-418

2017

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A framework for improving early detection of breast cancer in sub-Saharan Africa: A qualitative study of help-seeking behaviors among Malawian women

Patient education and counseling, 2017-01, Vol.100 (1), p.167-173

2017

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Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

Protein design algorithms predict viable resistance to an experimental antifolate

Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates

Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling

OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

Non-racemic Antifolates Stereo-selectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

1233. Identification of Novel Inhibitors of Clostridioides difficile Enoyl-Reductase II (FabK) by High-Throughput Virtual and Experimental Screening

Single Molecule Fluorescence Studies of Antibody Structure

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant italic toggle="yes">Klebsiella pneumoniae /italic> and italic toggle="yes">Enterobacter cloacae /italic

Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting

A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space

Feasibility of Patient Reporting of Symptomatic Adverse Events via the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in a Chemoradiotherapy Cooperative Group Multicenter Clinical Trial

A framework for improving early detection of breast cancer in sub-Saharan Africa: A qualitative study of help-seeking behaviors among Malawian women

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