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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Nature communications, 2016-12, Vol.7 (1), p.13837-13837, Article 13837

2016

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Nature chemical biology, 2011-04, Vol.7 (7), p.428

2011

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Cell reports (Cambridge), 2016-01, Vol.14 (2), p.298-309

2016

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The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

Cancer biology & therapy, 2012-09, Vol.13 (11), p.1072-1081

2012

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ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses

Cancer research (Chicago, Ill.), 2014-12, Vol.74 (23), p.6968-6979

2014

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Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Oncotarget, 2014-07, Vol.5 (14), p.5674-5685

2014

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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2320-2330

2011

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Cancer research (Chicago, Ill.), 2004-12, Vol.64 (24), p.9152-9159

2004

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Cell reports (Cambridge), 2016-12, Vol.17 (12), p.3407-3416

2016

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A DNA damage checkpoint response in telomere-initiated senescence

Nature, 2003-11, Vol.426 (6963), p.194-198

2003

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Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response

Current biology, 2006-01, Vol.16 (2), p.150-159

2006

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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

Acta crystallographica. Section D, Biological crystallography., 2014-05, Vol.70 (5), p.1465-1475

2014

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Development of pharmacodynamic biomarkers for ATR inhibitors

Molecular oncology, 2015-02, Vol.9 (2), p.463-472

2015

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Activation of the DNA damage response by telomere attrition: a passage to cellular senescence

Cell cycle (Georgetown, Tex.), 2004-05, Vol.3 (5), p.543-546

2004

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The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes

Oncogene, 2004-03, Vol.23 (10), p.1911-1921

2004

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Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence

Cell cycle (Georgetown, Tex.), 2004-05, Vol.3 (5), p.541-544

2004

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Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.369-369

2019

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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

A DNA damage checkpoint response in telomere-initiated senescence

Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA

Development of pharmacodynamic biomarkers for ATR inhibitors

Activation of the DNA damage response by telomere attrition: a passage to cellular senescence

The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes

Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence

Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy

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