UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 103

Sortiert nach

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

Clinical cancer research, 2012-10, Vol.18 (20), p.5650-5661

2012

Volltextzugriff (PDF)

Deconjugation of Dehydroamino Acids: Stereoselective Synthesis of Racemic (E)-Vinylglycines

Organic letters, 2005-11, Vol.7 (24), p.5433-5436

2005

Volltextzugriff (PDF)

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106

Molecular cancer therapeutics, 2010-01, Vol.9 (1), p.89-100

2010

Volltextzugriff (PDF)

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8328-8342

2011

Volltextzugriff (PDF)

Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4045-4049

2010

Volltextzugriff (PDF)

Complex Synthetic Chemical Libraries Indexed with Molecular Tags

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.10922-10926

1993

Volltextzugriff (PDF)

Automation in medicinal chemistry

Current topics in medicinal chemistry, 2004-03, Vol.4 (7), p.671

Reader, John C

2004

Volltextzugriff (PDF)

Surfing the piperazine core of tricyclic farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5537-5543

2005

Volltextzugriff (PDF)

Guiding farnesyltransferase inhibitors from an ECLiPS ® library to the catalytic zinc

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.507-511

2006

Volltextzugriff (PDF)

Solid-phase synthesis of dibenzoxazepinones

Tetrahedron letters, 2003-10, Vol.44 (44), p.8169-8172

2003

Volltextzugriff (PDF)

A Paradigm for Drug Discovery Employing Encoded Combinatorial Libraries

Proceedings of the National Academy of Sciences - PNAS, 1995-06, Vol.92 (13), p.6027-6031

1995

Volltextzugriff (PDF)

Exploring structure-activity relationships of tricyclic farnesyltransferase inhibitors using ECLiPS libraries

Combinatorial chemistry & high throughput screening, 2006-08, Vol.9 (7), p.545

2006

Volltextzugriff (PDF)

A novel strategy for regio- and stereocontrol in [4 + 2] cycloadditions. Intramolecular diels-alder reaction of a sllyl acetal triene

Tetrahedron letters, 1990, Vol.31 (45), p.6585-6588

1990

Volltextzugriff (PDF)

Abstract A235: Structure-guided evolution of potent and selective oral inhibitors of CHK1 through scaffold morphing

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A235-A235

2011

Volltextzugriff (PDF)

Abstract A228: CCT244747 is a novel, potent and selective inhibitor of CHK1 with oral efficacy both alone in neuroblastoma and in combination with genotoxic chemotherapeutic agents

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A228-A228

2011

Volltextzugriff (PDF)

Abstract 3518: Preclinical pharmacology of the novel, potent & selective CHK1 inhibitor SAR-020106

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3518-3518

2010

Volltextzugriff (PDF)

Solid phase synthesis of tetrahydro-1,4-benzodiazepin-2-ones

Tetrahedron letters, 2003-11, Vol.44 (46), p.8493-8495

2003

Volltextzugriff (PDF)

Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides

Journal of combinatorial chemistry, 2002-01, Vol.4 (1), p.23-32

2002

Volltextzugriff (PDF)

A Statistical-Based Approach To Assessing the Fidelity of Combinatorial Libraries Encoded with Electrophoric Molecular Tags. Development and Application of Tag Decode-Assisted Single Bead LC/MS Analysis

Journal of combinatorial chemistry, 2000-11, Vol.2 (6), p.716-731

2000

Volltextzugriff (PDF)

Intramolecular diels-alder reactions of silyl acetal trienes. The effect of stereoselectivity of allylic substitution

Tetrahedron letters, 1992-07, Vol.33 (28), p.4073-4076

1992

Volltextzugriff (PDF)

Intramolecular Diels-Alder reactions of silyl acetal trienes. Dienophile-controlled cycloadditions of ‘matched’ and ‘unmatched’ dimethylated substrates

Tetrahedron letters, 1992-10, Vol.33 (41), p.6165-6168

1992

Volltextzugriff (PDF)

Intramolecular diels-alder reactions of silyl acetal-tethered trienes

Tetrahedron, 1995-10, Vol.51 (42), p.11601-11622

1995

Volltextzugriff (PDF)

1 – 25 von 103

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(77)
Mit Volltextzugriff
(95)

Publikationsform

Sprache

Erscheinungsjahr

n.n

Thema

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

Deconjugation of Dehydroamino Acids: Stereoselective Synthesis of Racemic (E)-Vinylglycines

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases

Complex Synthetic Chemical Libraries Indexed with Molecular Tags

Automation in medicinal chemistry

Surfing the piperazine core of tricyclic farnesyltransferase inhibitors

Guiding farnesyltransferase inhibitors from an ECLiPS ® library to the catalytic zinc

Solid-phase synthesis of dibenzoxazepinones

A Paradigm for Drug Discovery Employing Encoded Combinatorial Libraries

Exploring structure-activity relationships of tricyclic farnesyltransferase inhibitors using ECLiPS libraries

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

A novel strategy for regio- and stereocontrol in [4 + 2] cycloadditions. Intramolecular diels-alder reaction of a sllyl acetal triene

Abstract A235: Structure-guided evolution of potent and selective oral inhibitors of CHK1 through scaffold morphing

Abstract A228: CCT244747 is a novel, potent and selective inhibitor of CHK1 with oral efficacy both alone in neuroblastoma and in combination with genotoxic chemotherapeutic agents

Abstract 3518: Preclinical pharmacology of the novel, potent & selective CHK1 inhibitor SAR-020106

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma

Solid phase synthesis of tetrahydro-1,4-benzodiazepin-2-ones

Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides

A Statistical-Based Approach To Assessing the Fidelity of Combinatorial Libraries Encoded with Electrophoric Molecular Tags. Development and Application of Tag Decode-Assisted Single Bead LC/MS Analysis

Intramolecular diels-alder reactions of silyl acetal trienes. The effect of stereoselectivity of allylic substitution

Intramolecular Diels-Alder reactions of silyl acetal trienes. Dienophile-controlled cycloadditions of ‘matched’ and ‘unmatched’ dimethylated substrates

Intramolecular diels-alder reactions of silyl acetal-tethered trienes

Suchergebnisse filtern