UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Nature communications, 2016-11, Vol.7 (1), p.13312-12, Article 13312

2016

Volltextzugriff (PDF)

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)‑1-((S)‑2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy‑N‑(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.599-618

2018

Volltextzugriff (PDF)

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005971-e1005971

2016

Volltextzugriff (PDF)

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

Scientific reports, 2016-10, Vol.6 (1), p.35351, Article 35351

2016

Volltextzugriff (PDF)

Targeting N-myristoylation for therapy of B-cell lymphomas

Nature communications, 2020-10, Vol.11 (1), p.5348-5348, Article 5348

2020

Volltextzugriff (PDF)

Sperm Toolbox-A selection of small molecules to study human spermatozoa

PloS one, 2024-02, Vol.19 (2), p.e0297666-e0297666

2024

Volltextzugriff (PDF)

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

PLoS neglected tropical diseases, 2015-09, Vol.9 (9), p.e0004014-e0004014

2015

Volltextzugriff (PDF)

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Molecules (Basel, Switzerland), 2021-03, Vol.26 (5), p.1396

2021

Volltextzugriff (PDF)

Target validation: linking target and chemical properties to desired product profile

Current topics in medicinal chemistry, 2011-05, Vol.11 (10), p.1275-1283

2011

Volltextzugriff (PDF)

Bespoke Drug Discovery Training for Low-Middle Income Countries

ACS medicinal chemistry letters, 2023-08, Vol.14 (8), p.1014-1016

2023

Volltextzugriff (PDF)

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

PLoS pathogens, 2020-11, Vol.16 (11), p.e1008932-e1008932

2020

Volltextzugriff (PDF)

N -myristoyltransferase inhibitors as new leads to treat sleeping sickness

Nature, 2010-04, Vol.464 (7289), p.728-732

2010

Volltextzugriff (PDF)

Anti-trypanosomatid drug discovery: progress and challenges

Nature reviews. Microbiology, 2023-01, Vol.21 (1), p.35-50

2023

Volltextzugriff (PDF)

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

eLife, 2016-05, Vol.5

2016

Volltextzugriff (PDF)

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9686-9720

2016

Volltextzugriff (PDF)

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.2893-2900

2010

Volltextzugriff (PDF)

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4699-4706

2013

Volltextzugriff (PDF)

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

PLoS pathogens, 2018-02, Vol.14 (2), p.e1006850

2018

Volltextzugriff (PDF)

Receptor occupancy and brain free fraction

Drug metabolism and disposition, 2009-04, Vol.37 (4), p.753-760

2009

Volltextzugriff (PDF)

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

PloS one, 2012-05, Vol.7 (5), p.e37097

2012

Volltextzugriff (PDF)

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Journal of cerebral blood flow and metabolism, 2012-05, Vol.32 (5), p.874-883

2012

Volltextzugriff (PDF)

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

Microorganisms (Basel), 2022-06, Vol.10 (7), p.1287

2022

Volltextzugriff (PDF)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Open biology, 2019-11, Vol.9 (11), p.190192-190192

2019

Volltextzugriff (PDF)

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Nature reviews. Microbiology, 2017-04, Vol.15 (4), p.217-231

2017

Volltextzugriff (PDF)

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

Forensic toxicology, 2018, Vol.36 (2), p.359-374

2018

Volltextzugriff (PDF)

1 – 25 von 234

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(214)
Mit Volltextzugriff
(193)

Publikationsform

Sprache

Englisch
(234)

Erscheinungsjahr

n.n

Thema

Science & Technology
(179)
Life Sciences & Biomedicine
(153)
Humans
(103)
Animals
(70)
Pharmacology & Pharmacy
(63)
Chemistry, Medicinal
(52)
Male
(51)
Female
(50)
Mice
(41)
Infectious Diseases
(35)
Structure-Activity Relationship
(32)
Drug Discovery
(27)
Adult
(25)
Biological And Medical Sciences
(24)
Physical Sciences
(23)
Medical Sciences
(21)
Multidisciplinary Sciences
(18)
Science & Technology - Other Topics
(18)
Enzyme Inhibitors - Pharmacology
(17)
Microbiology
(17)

15 weitere anzeigen...

Weniger anzeigen...

Neu hinzugefügt

Menü

Weitere Dienste

Einstellungen

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

Targeting N-myristoylation for therapy of B-cell lymphomas

Sperm Toolbox-A selection of small molecules to study human spermatozoa

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Target validation: linking target and chemical properties to desired product profile

Bespoke Drug Discovery Training for Low-Middle Income Countries

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

N -myristoyltransferase inhibitors as new leads to treat sleeping sickness

Anti-trypanosomatid drug discovery: progress and challenges

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

Receptor occupancy and brain free fraction

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

Suchergebnisse filtern