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Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

Nature communications, 2017-11, Vol.8 (1), p.1610-11, Article 1610

2017

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AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue

Nature metabolism, 2019-03, Vol.1 (3), p.340-349

2019

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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.864-884

2024

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17146-17183

2021

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X‑ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Journal of medicinal chemistry, 2017-11, Vol.60 (22), p.9299-9319

2017

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Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8533-8542

2013

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (49), p.E7880-E7889

2016

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Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

Nature chemical biology, 2014-02, Vol.10 (2), p.96

2014

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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Cancer research (Chicago, Ill.), 2016-02, Vol.76 (3), p.724-735

2016

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Discovery of 1‑Methyl‑1H‑imidazole Derivatives as Potent Jak2 Inhibitors

Journal of medicinal chemistry, 2014-01, Vol.57 (1), p.144-158

2014

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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1061-1073

2018

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5743-5747

2015

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1820-P: A Direct AMPK Activator Reduces Liver Steatosis in a Mouse Model of NASH

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5235-5244

2018

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Rapid Identification of Novel Allosteric PRC2 Inhibitors

ACS chemical biology, 2019-10, Vol.14 (10), p.2134-2140, Article acschembio.9b00468

2019

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Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors

Journal of medicinal chemistry, 2014-01, Vol.57 (1), p.144-158

2014

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Chloroquine Binds in the Cofactor Binding Site ofPlasmodium falciparum Lactate Dehydrogenase

The Journal of biological chemistry, 1999-04, Vol.274 (15), p.10213-10218

1999

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Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase

The Journal of biological chemistry, 1999-04, Vol.274 (15), p.10213-10218

1999

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Effector Sites in the Three-Dimensional Structure of Mammalian Sperm β-Acrosin

Structure (London), 2000-11, Vol.8 (11), p.1179-1188

2000

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Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Biochemical journal, 2017-08, Vol.474 (17), p.3059-3073

2017

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Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Science (American Association for the Advancement of Science), 2019-02, Vol.363 (6427), p.649-654

2019

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Lower Extremity Stiffness: Considerations for Testing, Performance Enhancement, and Injury Risk

Journal of strength and conditioning research, 2019-04, Vol.33 (4), p.1156-1166

2019

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The Luminosity and Mass Functions of Low-Mass Stars in the Galactic Disk. I. The Calibration Region

The Astronomical journal, 2008-11, Vol.136 (5), p.1778-1798

2008

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Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue

Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity

Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

X‑ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Discovery of 1‑Methyl‑1H‑imidazole Derivatives as Potent Jak2 Inhibitors

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

1820-P: A Direct AMPK Activator Reduces Liver Steatosis in a Mouse Model of NASH

Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Rapid Identification of Novel Allosteric PRC2 Inhibitors

Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors

Chloroquine Binds in the Cofactor Binding Site ofPlasmodium falciparum Lactate Dehydrogenase

Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase

Effector Sites in the Three-Dimensional Structure of Mammalian Sperm β-Acrosin

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Lower Extremity Stiffness: Considerations for Testing, Performance Enhancement, and Injury Risk

The Luminosity and Mass Functions of Low-Mass Stars in the Galactic Disk. I. The Calibration Region

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