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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Science (American Association for the Advancement of Science), 1994-01, Vol.263 (5145), p.380-384

1994

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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1446-1455

1998

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Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2156-2169

1996

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Design, Synthesis, and Evaluation of Tetrahydropyrimidinones as an Example of a General Approach to Nonpeptide HIV Protease Inhibitors

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1707-1719

1997

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Efavirenz is a potent nonnucleoside reverse transcriptase inhibitor of HIV type 1 replication in microglia in vitro

AIDS research and human retroviruses, 2000-10, Vol.16 (15), p.1527-1537

2000

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Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Journal of medicinal chemistry, 1996-08, Vol.39 (18), p.3514-3525

1996

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Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (24), p.2919-2924

1996

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Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease

Journal of Virology, 1997-08, Vol.71 (8), p.5723-5732

1997

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Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266

AIDS (London), 1996-09, Vol.10 (11), p.1205-1209

1996

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The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (7), p.823-828

1998

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Population Dynamics Studies of Wild-Type and Drug-Resistant Mutant HIV in Mixed Infections

Virology (New York, N.Y.), 1997-09, Vol.236 (1), p.85-94

1997

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Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors

Bioorganic & medicinal chemistry letters, 1996-06, Vol.6 (12), p.1371-1374

1996

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Functionalized aliphatic P2/P2′ analogs of HIV-1 protease inhibitor DMP323

Bioorganic & medicinal chemistry letters, 1997-06, Vol.7 (11), p.1365-1370

1997

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Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

Chemistry & biology, 1996-04, Vol.3 (4), p.301-314

1996

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DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

Antimicrobial Agents and Chemotherapy, 2002-05, Vol.46 (5), p.1394-1401

2002

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Repetition Priming of Words and Pseudowords in Divided Attention and in Amnesia

Journal of experimental psychology. Learning, memory, and cognition, 1990-11, Vol.16 (6), p.1033-1042

1990

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HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide

AIDS research and human retroviruses, 1990-09, Vol.6 (9), p.1115-1123

1990

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Women in chemistry: their changing roles from alchemical times to the mid-twientieth century

Canadian Chemical News, 1999, Vol.51 (3), p.38

1999

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A Devotion to Their Science: Pioneer Women of Radioactivity

Canadian Chemical News, 1998, Vol.50 (3), p.37

1998

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors

Design, Synthesis, and Evaluation of Tetrahydropyrimidinones as an Example of a General Approach to Nonpeptide HIV Protease Inhibitors

Efavirenz is a potent nonnucleoside reverse transcriptase inhibitor of HIV type 1 replication in microglia in vitro

Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups

Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease

Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266

The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues

Population Dynamics Studies of Wild-Type and Drug-Resistant Mutant HIV in Mixed Infections

Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors

Functionalized aliphatic P2/P2′ analogs of HIV-1 protease inhibitor DMP323

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

Repetition Priming of Words and Pseudowords in Divided Attention and in Amnesia

HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide

Women in chemistry: their changing roles from alchemical times to the mid-twientieth century

A Devotion to Their Science: Pioneer Women of Radioactivity

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