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Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors

Current medicinal chemistry, 2011-06, Vol.18 (18), p.2686-2714

2011

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Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Leukemia, 2012-07, Vol.26 (7), p.1462-1470

2012

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Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

British journal of cancer, 2005-10, Vol.93 (9), p.1011-1018

2005

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Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-05, Vol.877 (13), p.1352-1358

2009

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A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer

Annals of oncology, 2020-05, Vol.31 (5), p.619-625

2020

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Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer

Annals of oncology, 2018-09, Vol.29 (9), p.1918-1925

2018

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cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice

Clinical cancer research, 1997-11, Vol.3 (11), p.2063-2074

1997

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Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice

Cancer chemotherapy and pharmacology, 2004-12, Vol.54 (6), p.475-486

2004

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Biotransformation of the platinum drug JM216 following oral administration to cancer patients

Cancer chemotherapy and pharmacology, 1996, Vol.38 (2), p.155-162

1996

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Intracellular metabolism of the orally active platinum drug JM216: influence of glutathione levels

British journal of cancer, 1996-08, Vol.74 (3), p.380-386

1996

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Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry

Journal of Chromatography A, 1995-09, Vol.712 (1), p.61-66

1995

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Determination of metabolites of a novel platinum anticancer drug JM216 in human plasma ultrafiltrates

Journal of pharmaceutical and biomedical analysis, 1995-11, Vol.13 (12), p.1493-1498

1995

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A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

British journal of cancer, 2009-12, Vol.101 (11), p.1860-1868

2009

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Metabolism, protein binding and in vivo activity of the oral platinum drug JM216 and its biotransformation products

Anticancer research, 1996-07, Vol.16 (4A), p.1857

1996

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Discovery and validation of biomarkers to support clinical development of NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitor

European journal of cancer (1990), 2022-10, Vol.174, p.S35-S35

2022

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Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice

The Journal of pharmacology and experimental therapeutics, 1997-04, Vol.281 (1), p.420

1997

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Drugging the PI3 kinome

Nature biotechnology, 2006-07, Vol.24 (7), p.794-796

2006

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Preclinical pharmacology of 1069C85, a novel tubulin binder

Cancer chemotherapy and pharmacology, 1994, Vol.35 (2), p.169-173

1994

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Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

Molecular cancer therapeutics, 2005-10, Vol.4 (10), p.1521-1532

2005

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Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance

Journal of inorganic biochemistry, 1999-10, Vol.77 (1), p.111-115

1999

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Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002: Quantitative Analysis of Biomarkers by LC-MS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Vol.877 (13), p.1352-1358

2009

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Obstetric management does not influence vertical transmission of HCV infection: results of the ALHICE group study

The journal of maternal-fetal & neonatal medicine, 2014-05, Vol.27 (7), p.664-670

2014

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In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202

Clinical cancer research, 2005-07, Vol.11 (13), p.4875-4888

2005

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Selective FLT3 inhibition of FLT3-ITD super(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Leukemia, 2012-07, Vol.26 (7), p.1462-1470

2012

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Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

Molecular cancer therapeutics, 2006-01, Vol.5 (1), p.187-196

2006

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Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors

Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002

A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer

Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer

cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice

Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice

Biotransformation of the platinum drug JM216 following oral administration to cancer patients

Intracellular metabolism of the orally active platinum drug JM216: influence of glutathione levels

Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry

Determination of metabolites of a novel platinum anticancer drug JM216 in human plasma ultrafiltrates

A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

Metabolism, protein binding and in vivo activity of the oral platinum drug JM216 and its biotransformation products

Discovery and validation of biomarkers to support clinical development of NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitor

Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice

Drugging the PI3 kinome

Preclinical pharmacology of 1069C85, a novel tubulin binder

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance

Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002: Quantitative Analysis of Biomarkers by LC-MS/MS

Obstetric management does not influence vertical transmission of HCV infection: results of the ALHICE group study

In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202

Selective FLT3 inhibition of FLT3-ITD super(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

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