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Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development

Clinical cancer research, 2004-06, Vol.10 (11), p.3885-3896

2004

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Introduction to the molecular biology of cancer: translation to the clinic

Progress in molecular biology and translational science, 2010, Vol.95, p.1-8

Ruddon, Raymond W

2010

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Use of CA-125 in clinical trial evaluation of new therapeutic drugs for ovarian cancer

Clinical cancer research, 2004-06, Vol.10 (11), p.3919-3926

2004

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Reanalysis of cancer drugs: Old drugs, new tricks

Clinical cancer research, 2004-06, Vol.10 (11), p.3897-3907

2004

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Redox conditions for stimulation of in vitro folding and assembly of the glycoprotein hormone chorionic gonadotropin

Biotechnology and bioengineering, 1994-06, Vol.44 (1), p.66-72

1994

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Intracellular Folding Pathway of the Cystine Knot-Containing Glycoprotein Hormone α-Subunit

Biochemistry (Easton), 2001-01, Vol.40 (2), p.577-585

2001

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Functional Contributions of Noncysteine Residues within the Cystine Knots of Human Chorionic Gonadotropin Subunits

The Journal of biological chemistry, 2001-04, Vol.276 (14), p.10692-10699

2001

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Biomarkers, Surrogate End Points, and the Acceleration of Drug Development for Cancer Prevention and Treatment

Clinical cancer research, 2004-06, Vol.10 (11), p.3881-3884

2004

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Super hormones

Nature biotechnology, 1996-10, Vol.14 (10), p.1224-1224

Ruddon, Raymond W

1996

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Assisted Protein Folding

The Journal of biological chemistry, 1997-02, Vol.272 (6), p.3125-3128

1997

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Dissociation of Early Folding Events from Assembly of the Human Lutropin β-Subunit

Molecular endocrinology (Baltimore, Md.), 1998-10, Vol.12 (10), p.1640-1649

1998

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Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: An update

Clinical cancer research, 2004-06, Vol.10 (11), p.3881-3884

2004

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Cystine knot mutations affect the folding of the glycoprotein hormone alpha-subunit. Differential secretion and assembly of partially folded intermediates

The Journal of biological chemistry, 2000-05, Vol.275 (20), p.15413-15421

2000

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Protein folding in the endoplasmic reticulum: Lessons from the human chorionic gonadotropin β subunit

Protein science, 1996-08, Vol.5 (8), p.1443-1452

1996

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Biosynthesis and secretion of laminin and laminin-associated glycoproteins by nonmalignant and malignant human keratinocytes: comparison of cell lines from primary and secondary tumors in the same patient

Cancer research (Chicago, Ill.), 1988-09, Vol.48 (18), p.5193-5202

1988

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Human chorionic gonadotropin-beta gene expression in first trimester placenta

Endocrinology (Philadelphia), 1997-12, Vol.138 (12), p.5459-5465

1997

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The Asparagine-linked Oligosaccharides of the Human Chorionic Gonadotropin β Subunit Facilitate Correct Disulfide Bond Pairing

The Journal of biological chemistry, 1995-05, Vol.270 (20), p.11851-11859

1995

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A naturally occurring genetic variant in the human chorionic gonadotropin-beta gene 5 is assembly inefficient

Endocrinology (Philadelphia), 1999-08, Vol.140 (8), p.3496-3506

1999

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Intracellular folding pathway of human chorionic gonadotropin beta subunit

The Journal of biological chemistry, 1992-05, Vol.267 (13), p.8870-8879

1992

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Carcinoembryonic antigen for monitoring patients with small cell carcinoma of the lung during treatment

Cancer research (Chicago, Ill.), 1980-12, Vol.40 (12), p.4420-4427

1980

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Cystine Knot Mutations Affect the Folding of the Glycoprotein Hormone Î±-Subunit

The Journal of biological chemistry, 2000-05, Vol.275 (20), p.15413

2000

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Cystine Knot Mutations Affect the Folding of the Glycoprotein Hormone α-Subunit

The Journal of biological chemistry, 2000-05, Vol.275 (20), p.15413-15421

2000

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Stimulation of synthesis and secretion of chorionic gonadotropin subunits by eutopic and ectopic hormone-producing human cell lines

Cancer research (Chicago, Ill.), 1980-12, Vol.40 (12), p.4519-4523

1980

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Reanalysis of Cancer Drugs

Clinical cancer research, 2004-06, Vol.10 (11), p.3897-3907

2004

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Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: an update prologue

Clinical cancer research, 2004-06, Vol.10 (11), p.3881-3884

2004

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Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development

Introduction to the molecular biology of cancer: translation to the clinic

Use of CA-125 in clinical trial evaluation of new therapeutic drugs for ovarian cancer

Reanalysis of cancer drugs: Old drugs, new tricks

Redox conditions for stimulation of in vitro folding and assembly of the glycoprotein hormone chorionic gonadotropin

Intracellular Folding Pathway of the Cystine Knot-Containing Glycoprotein Hormone α-Subunit

Functional Contributions of Noncysteine Residues within the Cystine Knots of Human Chorionic Gonadotropin Subunits

Biomarkers, Surrogate End Points, and the Acceleration of Drug Development for Cancer Prevention and Treatment

Super hormones

Assisted Protein Folding

Dissociation of Early Folding Events from Assembly of the Human Lutropin β-Subunit

Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: An update

Cystine knot mutations affect the folding of the glycoprotein hormone alpha-subunit. Differential secretion and assembly of partially folded intermediates

Protein folding in the endoplasmic reticulum: Lessons from the human chorionic gonadotropin β subunit

Biosynthesis and secretion of laminin and laminin-associated glycoproteins by nonmalignant and malignant human keratinocytes: comparison of cell lines from primary and secondary tumors in the same patient

Human chorionic gonadotropin-beta gene expression in first trimester placenta

The Asparagine-linked Oligosaccharides of the Human Chorionic Gonadotropin β Subunit Facilitate Correct Disulfide Bond Pairing

A naturally occurring genetic variant in the human chorionic gonadotropin-beta gene 5 is assembly inefficient

Intracellular folding pathway of human chorionic gonadotropin beta subunit

Carcinoembryonic antigen for monitoring patients with small cell carcinoma of the lung during treatment

Cystine Knot Mutations Affect the Folding of the Glycoprotein Hormone Î±-Subunit

Cystine Knot Mutations Affect the Folding of the Glycoprotein Hormone α-Subunit

Stimulation of synthesis and secretion of chorionic gonadotropin subunits by eutopic and ectopic hormone-producing human cell lines

Reanalysis of Cancer Drugs

Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: an update prologue

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