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Species differences in drug transporters and implications for translating preclinical findings to humans

Expert opinion on drug metabolism & toxicology, 2013-03, Vol.9 (3), p.237-252

2013

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Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2357-2367

2017

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Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics

Drug metabolism and disposition, 2015-03, Vol.43 (3), p.367-374

2015

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Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex

Drug metabolism and disposition, 2014-01, Vol.42 (1), p.78

2014

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Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.900-915

2018

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Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

CPT: pharmacometrics and systems pharmacology, 2022-01, Vol.11 (1), p.55-67

2022

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Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics

Clinical pharmacology and therapeutics, 2019-07, Vol.106 (1), p.228-237

2019

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Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters

Drug metabolism and disposition, 2015-05, Vol.43 (5), p.774-785

2015

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Pitavastatin is a more sensitive and selective organic anion‐transporting polypeptide 1B clinical probe than rosuvastatin

British journal of clinical pharmacology, 2014-09, Vol.78 (3), p.587-598

2014

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Physiologically‐based pharmacokinetic modeling for primary metabolites of CYP3A and P‐glycoprotein inhibitors in drug–drug interactions: Should we assume the free drug hypothesis?

CPT: pharmacometrics and systems pharmacology, 2023-01, Vol.12 (1), p.8-12

2023

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Corrigendum to: Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

CPT: pharmacometrics and systems pharmacology, 2022-10, Vol.11 (10), p.1394-1394

2022

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The hurdle of human PK Predictions for hepatic oatp substrates: lessons learned from rat allometry

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S67-S67

2019

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In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective

Drug metabolism and disposition, 2009-07, Vol.37 (7), p.1339

2009

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Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

CPT: pharmacometrics and systems pharmacology, 2023-02, Vol.12 (2), p.261-273

2023

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Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

CPT: pharmacometrics and systems pharmacology, 2024-01, Vol.13 (1), p.118-131

2024

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Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1046

2008

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Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.673

2007

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Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity

Molecular pharmacology, 2008-08, Vol.74 (2), p.309

2008

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Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist

Clinical pharmacology in drug development, 2022-01, Vol.11 (1), p.123-128

2022

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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Drug metabolism and disposition, 2014-08, Vol.42 (8), p.1301

2014

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Assessment of Pharmacokinetic Interaction Between Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin

Clinical pharmacology in drug development, 2022-03, Vol.11 (3), p.406-412

2022

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Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

Nucleic acids research, 2009-03, Vol.37 (4), p.1160

2009

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Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases

Molecular pharmacology, 2012-02, Vol.81 (2), p.220-227

2012

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P84 - A platform for evaluating in vivo OATP1B inhibition risk in cynomolgus monkeys and translation to human

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S47-S48

2020

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P234 - Use of a bile salt export pump knockdown rat susceptibility model to interrogate mechanism of drug induced liver toxicity

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S93-S93

2020

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Species differences in drug transporters and implications for translating preclinical findings to humans

Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions

Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics

Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters

Pitavastatin is a more sensitive and selective organic anion‐transporting polypeptide 1B clinical probe than rosuvastatin

Physiologically‐based pharmacokinetic modeling for primary metabolites of CYP3A and P‐glycoprotein inhibitors in drug–drug interactions: Should we assume the free drug hypothesis?

Corrigendum to: Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

The hurdle of human PK Predictions for hepatic oatp substrates: lessons learned from rat allometry

In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective

Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction

Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein

Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity

Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK‐7264), a P2X3 Receptor Antagonist

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Assessment of Pharmacokinetic Interaction Between Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases

P84 - A platform for evaluating in vivo OATP1B inhibition risk in cynomolgus monkeys and translation to human

P234 - Use of a bile salt export pump knockdown rat susceptibility model to interrogate mechanism of drug induced liver toxicity

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