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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Scientific reports, 2021-09, Vol.11 (1), p.19422-19422, Article 19422

2021

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

Nature immunology, 2003-08, Vol.4 (8), p.794-800

2003

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Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

The Journal of immunology (1950), 2010-09, Vol.185 (6), p.3694-3701

2010

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Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

Scientific reports, 2018-03, Vol.8 (1), p.4941-13, Article 4941

2018

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Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

Scientific reports, 2019-10, Vol.9 (1), p.14042-12, Article 14042

2019

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Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys

Drug development and industrial pharmacy, 2019-03, Vol.45 (3), p.387-394

2019

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A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans

Current biology, 2001-06, Vol.11 (11), p.809-821

2001

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IκB Kinase ϵ Interacts with p52 and Promotes Transactivation via p65

The Journal of biological chemistry, 2006-11, Vol.281 (46), p.34973-34981

2006

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Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils

Clinical and molecular allergy CMA, 2005-04, Vol.3 (1), p.5-5, Article 5

2005

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Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor alpha, and inhibition by glucocorticoids

Biochemical journal, 1997-12, Vol.328 ( Pt 2) (2), p.707-715

1997

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A search within the IL-1 type I receptor reveals a peptide with hydropathic complementarity to the IL-1β trigger loop which binds to IL-1 and inhibits in vitro responses

Molecular immunology, 1999-12, Vol.36 (17), p.1141-1148

1999

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Formation and Biochemical Characterization of Tube/Pelle Death Domain Complexes: Critical Regulators of Postreceptor Signaling by the Drosophila Toll Receptor

Biochemistry (Easton), 1999-09, Vol.38 (36), p.11722-11733

1999

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Turnover of adenosine 3',5'-monophosphate in WI-38 cultured fibroblasts

Biochemistry (Easton), 1980-06, Vol.19 (12), p.2560-2567

1980

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Targeting IKKβ for the treatment of rheumatoid arthritis

Drug news & perspectives, 2010-10, Vol.23 (8), p.483-490

2010

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Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

British journal of pharmacology, 1996-07, Vol.118 (5), p.1111-1118

1996

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Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: Does variable inhibition of interleukin‐6 production limit effectiveness in vivo?

Arthritis and rheumatism, 2010-11, Vol.62 (11), p.3221-3231

2010

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Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-kappa B) pathway activation: IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation

Biochemical journal, 2001-10, Vol.359 (Pt 2), p.403-410

2001

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116 Treatment with Non-steroidal Anti-inflammatory Drugs Increases TNF Production in Rheumatoid Arthritis

Cytokine (Philadelphia, Pa.), 2007-07, Vol.39 (1), p.32-32

2007

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IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65

The Journal of biological chemistry, 2006-11, Vol.281 (46), p.34973-34981

2006

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IÎºB Kinase Ïµ Interacts with p52 and Promotes Transactivation via p65

The Journal of biological chemistry, 2006-11, Vol.281 (46), p.34973

2006

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Effects of growth hormone-releasing factor, somatostatin and dopamine on growth hormone and prolactin secretion from cultured ovine pituitary cells

FEBS letters, 1984-01, Vol.166 (1), p.189-193

1984

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A Reverse Genetic Analysis of Components of the Toll Signaling Pathway in Caenorhabditis elegans

Current biology, 2006-07, Vol.16 (14), p.1477-1477

2006

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Single doses of p38 MAP kinase inhibitors or prednisolone affect CRP and IL-6 in patients with active Rheumatoid Arthritis (RA)

Open journal of immunology, 2012, Vol.2 (3), p.85-97

2012

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Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1β-stimulated nuclear factor κB (NF-κB) pathway activation: IRAK-1 associates with the NF-κB essential modulator (NEMO) upon receptor stimulation

Biochemical journal, 2001-10, Vol.359 (2), p.403-410

2001

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Glucocorticoid inhibition of cytokine-induced E-selectin promoter activation

Biochemical Society transactions, 1997-05, Vol.25 (2), p.189S

1997

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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys

A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans

IκB Kinase ϵ Interacts with p52 and Promotes Transactivation via p65

Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils

Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor alpha, and inhibition by glucocorticoids

A search within the IL-1 type I receptor reveals a peptide with hydropathic complementarity to the IL-1β trigger loop which binds to IL-1 and inhibits in vitro responses

Formation and Biochemical Characterization of Tube/Pelle Death Domain Complexes: Critical Regulators of Postreceptor Signaling by the Drosophila Toll Receptor

Turnover of adenosine 3',5'-monophosphate in WI-38 cultured fibroblasts

Targeting IKKβ for the treatment of rheumatoid arthritis

Reduction by inhibitors of mono(ADP‐ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: Does variable inhibition of interleukin‐6 production limit effectiveness in vivo?

Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-kappa B) pathway activation: IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation

116 Treatment with Non-steroidal Anti-inflammatory Drugs Increases TNF Production in Rheumatoid Arthritis

IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65

IÎºB Kinase Ïµ Interacts with p52 and Promotes Transactivation via p65

Effects of growth hormone-releasing factor, somatostatin and dopamine on growth hormone and prolactin secretion from cultured ovine pituitary cells

A Reverse Genetic Analysis of Components of the Toll Signaling Pathway in Caenorhabditis elegans

Single doses of p38 MAP kinase inhibitors or prednisolone affect CRP and IL-6 in patients with active Rheumatoid Arthritis (RA)

Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1β-stimulated nuclear factor κB (NF-κB) pathway activation: IRAK-1 associates with the NF-κB essential modulator (NEMO) upon receptor stimulation

Glucocorticoid inhibition of cytokine-induced E-selectin promoter activation

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