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Efflux pump proteins in antifungal resistance

Frontiers in pharmacology, 2014, Vol.5, p.202-202

2014

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Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates of Candida albicans

The Journal of biological chemistry, 2013-06, Vol.288 (23), p.16775-16787

2013

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Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

Scientific reports, 2016-06, Vol.6 (1), p.27132, Article 27132

2016

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Antifungals: Mechanism of Action and Drug Resistance

Advances in experimental medicine and biology, 2016, Vol.892, p.327-349

2016

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Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1

Biochimica et biophysica acta, 2016-11, Vol.1858 (11), p.2858-2870

2016

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Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p

Scientific reports, 2015-06, Vol.5 (1), p.11211, Article 11211

2015

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Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter

Journal of molecular biology, 2018-03, Vol.430 (5), p.682-694

2018

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Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport

Biochimica et biophysica acta. Biomembranes, 2017-10, Vol.1859 (10), p.1778-1789

2017

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Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters

Journal of natural products (Washington, D.C.), 2017-02, Vol.80 (2), p.479-487

2017

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Withdrawal: Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

The Journal of biological chemistry, 2020-03, Vol.295 (10), p.3393-3393

2020

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Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps

Planta medica, 2016-08, Vol.82 (13), p.1180

2016

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Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

Journal of natural products (Washington, D.C.), 2014-12, Vol.77 (12), p.2700-2706

2014

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Candida Efflux ATPases and Antiporters in Clinical Drug Resistance

Advances in experimental medicine and biology, 2016, Vol.892, p.351-376

2016

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Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model

Bioorganic & medicinal chemistry, 2017-07, Vol.25 (13), p.3278-3284

2017

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ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance

FEMS yeast research, 2015-08, Vol.15 (5), p.fov036

2015

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Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

The Journal of biological chemistry, 2013-08, Vol.288 (34), p.24480-24493

2013

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Erratum: Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

Scientific reports, 2016-07, Vol.6 (1), p.30221-30221, Article 30221

2016

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Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

Journal of amino acids, 2011-01, Vol.2011, p.531412-12

2011

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An Introduction to Microbial Genomic Islands for Evolutionary Adaptation and Pathogenicity

Microbial Genomic Islands in Adaptation and Pathogenicity, 2023, p.1-15

2023

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Efflux pump proteins in antifungal resistance

Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates of Candida albicans

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

Antifungals: Mechanism of Action and Drug Resistance

Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1

Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p

Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter

Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport

Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters

Withdrawal: Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans

Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps

Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

Candida Efflux ATPases and Antiporters in Clinical Drug Resistance

Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model

ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance

Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

Erratum: Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

An Introduction to Microbial Genomic Islands for Evolutionary Adaptation and Pathogenicity

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