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Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis

Organic process research & development, 2020-02, Vol.24 (2), p.183-200

2020

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Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification

Organic process research & development, 2020-08, Vol.24 (8), p.1373-1392

2020

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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.380-383

2008

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Bifunctional Abietadiene Synthase: Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites

Journal of the American Chemical Society, 2001-09, Vol.123 (37), p.8974-8978

2001

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Abietadiene Synthase from Grand Fir (Abies grandis): Characterization and Mechanism of Action of the “Pseudomature” Recombinant Enzyme

Biochemistry (Easton), 2000-12, Vol.39 (50), p.15592-15602

2000

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Mechanism of Abietadiene Synthase Catalysis: Stereochemistry and Stabilization of the Cryptic Pimarenyl Carbocation Intermediates

Journal of the American Chemical Society, 2002-06, Vol.124 (24), p.6998-7006

2002

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Process Development of a Diacyl Glycerolacyltransferase-1 Inhibitor

Organic process research & development, 2010-03, Vol.14 (2), p.417-424

2010

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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate

Molecular cancer therapeutics, 2022-08, Vol.21 (8), p.1326-1336

2022

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Stereochemistry of the Cyclization-Rearrangement of (+)-Copalyl Diphosphate to (−)-Abietadiene Catalyzed by Recombinant Abietadiene Synthase from Abies grandis

Organic letters, 2000-03, Vol.2 (5), p.573-576

2000

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Process development of ABT-450 – A first generation NS3/4A protease inhibitor for HCV

Tetrahedron, 2019-08, Vol.75 (32), p.4271-4286

2019

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Stereospecific intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to (−)-abietadiene catalyzed by recombinant cyclase from grand fir (Abies grandis)

Chemical communications (Cambridge, England), 1998-01 (1), p.21-22

1998

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Abstract B116: Optimizing a CD71-targeting Probody drug conjugate (PDC) for activity in multiple solid tumor and lymphoma models and for tolerability in nonhuman primates

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B116-B116

2018

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Abstract 6311: ABBV-400: An ADC delivering a novel topoisomerase 1 inhibitor to c-Met-positive solid tumors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6311-6311

2023

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Synthesis of Allylic Isoprenoid Diphosphates by SN2 Displacement of Diethyl Phosphate

European journal of organic chemistry, 2000-04, Vol.2000 (8), p.1401-1410

2000

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Synthesis and characterization of abietadiene, levopimaradiene, palustradiene, and neoabietadiene: hydrocarbon precursors of the abietane diterpene resin acids

Tetrahedron, 2001-07, Vol.57 (29), p.6155-6167

2001

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Stereochemistry and mechanism of the enzyme-catalyzed cyclization of geranylgeranyl diphosphate to (-)-abietadiene

Ravn, Matthew M

2000

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ChemInform Abstract: Stereochemistry of the Cyclization-Rearrangement of (+)-Copalyl Diphosphate to (-)-Abietadiene Catalyzed by Recombinant Abietadiene Synthase from Abies grandis

ChemInform, 2000-06, Vol.31 (24), p.no-no

2000

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The harlequin ladybird, Harmonia axyridis: global perspectives on invasion history and ecology

Biological invasions, 2016-04, Vol.18 (4), p.997-1044

2016

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2023 ESC Guidelines for the management of acute coronary syndromes

European heart journal, 2023-10, Vol.44 (38), p.3720-3826

2023

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Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

Cell stem cell, 2021-04, Vol.28 (4), p.718-731.e6

2021

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Recombinant expression and in vitro characterisation of active Huwentoxin-IV

PloS one, 2013-12, Vol.8 (12), p.e83202

2013

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Genre in the Climate Debate

2021

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Traceability

Internet policy review, 2022-01, Vol.11 (1), p.1-12

2022

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Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists

Biochemical journal, 2016-09, Vol.473 (18), p.2881-2891

2016

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Development and characterisation of a novel glucagon like peptide-1 receptor antibody

Diabetologia, 2018-03, Vol.61 (3), p.711-721

2018

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Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Bifunctional Abietadiene Synthase: Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites

Abietadiene Synthase from Grand Fir (Abies grandis): Characterization and Mechanism of Action of the “Pseudomature” Recombinant Enzyme

Mechanism of Abietadiene Synthase Catalysis: Stereochemistry and Stabilization of the Cryptic Pimarenyl Carbocation Intermediates

Process Development of a Diacyl Glycerolacyltransferase-1 Inhibitor

Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate

Stereochemistry of the Cyclization-Rearrangement of (+)-Copalyl Diphosphate to (−)-Abietadiene Catalyzed by Recombinant Abietadiene Synthase from Abies grandis

Process development of ABT-450 – A first generation NS3/4A protease inhibitor for HCV

Stereospecific intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to (−)-abietadiene catalyzed by recombinant cyclase from grand fir (Abies grandis)

Abstract B116: Optimizing a CD71-targeting Probody drug conjugate (PDC) for activity in multiple solid tumor and lymphoma models and for tolerability in nonhuman primates

Abstract 6311: ABBV-400: An ADC delivering a novel topoisomerase 1 inhibitor to c-Met-positive solid tumors

Synthesis of Allylic Isoprenoid Diphosphates by SN2 Displacement of Diethyl Phosphate

Synthesis and characterization of abietadiene, levopimaradiene, palustradiene, and neoabietadiene: hydrocarbon precursors of the abietane diterpene resin acids

Stereochemistry and mechanism of the enzyme-catalyzed cyclization of geranylgeranyl diphosphate to (-)-abietadiene

ChemInform Abstract: Stereochemistry of the Cyclization-Rearrangement of (+)-Copalyl Diphosphate to (-)-Abietadiene Catalyzed by Recombinant Abietadiene Synthase from Abies grandis

The harlequin ladybird, Harmonia axyridis: global perspectives on invasion history and ecology

2023 ESC Guidelines for the management of acute coronary syndromes

Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

Recombinant expression and in vitro characterisation of active Huwentoxin-IV

Genre in the Climate Debate

Traceability

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

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