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Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro

International journal of molecular sciences, 2020-07, Vol.21 (13), p.4708

2020

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Inhibition and induction of human cytochrome P450 enzymes: current status

Archives of toxicology, 2008-10, Vol.82 (10), p.667-715

2008

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Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.923-933

2018

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In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

European journal of pharmaceutical sciences, 2020-01, Vol.141, p.105118, Article 105118

2020

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The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico

Current drug metabolism, 2006-10, Vol.7 (7), p.705

2006

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Pinoresinol stimulates keratinocyte proliferation and downregulates TNF‐α secretion in peripheral blood mononuclear cells: An experimental in vitro study

Health science reports, 2023-01, Vol.6 (1), p.e998-n/a

2023

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Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung

Critical reviews in toxicology, 2002-01, Vol.32 (5), p.391-411

2002

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Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.743-754

2018

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Cytochrome P450-activated prodrugs: targeted drug delivery

Current medicinal chemistry, 2008-10, Vol.15 (23), p.2346

2008

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A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors

Frontiers in pharmacology, 2022-03, Vol.13, p.831791-831791

2022

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In silico toxicology - non-testing methods

Frontiers in pharmacology, 2011-01, Vol.2, p.33

Raunio, Hannu

2011

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Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Frontiers in chemistry, 2018-03, Vol.6, p.41-41

2018

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Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver

Current drug metabolism, 2013-01, Vol.14 (1), p.137

2013

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Prodrugs--from serendipity to rational design

Pharmacological reviews, 2011-09, Vol.63 (3), p.750

2011

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Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

ACS omega, 2021-05, Vol.6 (17), p.11286-11296

2021

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Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

Basic & clinical pharmacology & toxicology, 2005-03, Vol.96 (3), p.167-175

2005

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CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds

Drug metabolism and disposition, 2011-12, Vol.39 (12), p.2283

2011

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Metabolism of bilirubin by human cytochrome P450 2A6

Toxicology and applied pharmacology, 2012-05, Vol.261 (1), p.50-58

2012

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Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids

Phytomedicine (Stuttgart), 2011-04, Vol.18 (6), p.533-538

2011

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Polymorphisms of CYP2A6 and its practical consequences

British journal of clinical pharmacology, 2001-10, Vol.52 (4), p.357-363

2001

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Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.626

2004

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Predictive Three-Dimensional Quantitative Structure−Activity Relationship of Cytochrome P450 1A2 Inhibitors

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3808-3815

2005

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Identification of novel CYP2A6 inhibitors by virtual screening

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7186-7193

2011

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Regulation of CYP3A genes in the human respiratory tract

Chemico-biological interactions, 2005-01, Vol.151 (2), p.53-62

2005

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Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.412

2011

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Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro

Inhibition and induction of human cytochrome P450 enzymes: current status

Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico

Pinoresinol stimulates keratinocyte proliferation and downregulates TNF‐α secretion in peripheral blood mononuclear cells: An experimental in vitro study

Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung

Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

Cytochrome P450-activated prodrugs: targeted drug delivery

A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors

In silico toxicology - non-testing methods

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver

Prodrugs--from serendipity to rational design

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling

Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds

Metabolism of bilirubin by human cytochrome P450 2A6

Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids

Polymorphisms of CYP2A6 and its practical consequences

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

Predictive Three-Dimensional Quantitative Structure−Activity Relationship of Cytochrome P450 1A2 Inhibitors

Identification of novel CYP2A6 inhibitors by virtual screening

Regulation of CYP3A genes in the human respiratory tract

Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

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