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P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design

Molecular pharmaceutics, 2006-01, Vol.3 (1), p.3-25

Raub, Thomas J

2006

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Integration of in Silico and in Vitro Tools for Scaffold Optimization during Drug Discovery: Predicting P‑Glycoprotein Efflux

Molecular pharmaceutics, 2013-04, Vol.10 (4), p.1249-1261

2013

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In Silico and in Vitro Assessment of OATP1B1 Inhibition in Drug Discovery

Molecular pharmaceutics, 2018-08, Vol.15 (8), p.3060-3068

2018

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QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain: Incorporating P-glycoprotein Efflux as a Variable

Journal of chemical information and modeling, 2016-11, Vol.56 (11), p.2225-2233

2016

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Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1251

2009

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The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

Molecular pharmacology, 2006-12, Vol.70 (6), p.2127-2133

2006

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Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

Drug metabolism and disposition, 2015-09, Vol.43 (9), p.1360-1371

2015

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How hydrogen bonds impact P-glycoprotein transport and permeability

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6540-6548

2012

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Rhodamine Inhibitors of P-Glycoprotein: An Amide/Thioamide “Switch” for ATPase Activity

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3328-3341

2009

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Efficiency Gains in Tracer Identification for Nuclear Imaging: Can In Vivo LC-MS/MS Evaluation of Small Molecules Screen for Successful PET Tracers?

ACS chemical neuroscience, 2014-12, Vol.5 (12), p.1154-1163

2014

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Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.61

2008

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Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1916

2009

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Determination of the Affinity of Drugs toward Serum Albumin by Measurement of the Quenching of the Intrinsic Tryptophan Fluorescence of the Protein

Journal of pharmacy and pharmacology, 1999-01, Vol.51 (1), p.41-48

1999

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Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Antimicrobial Agents and Chemotherapy, 2007-09, Vol.51 (9), p.3230-3234

2007

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QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, K p,uu,brain: Incorporating P‑glycoprotein Efflux as a Variable

Journal of chemical information and modeling, 2016-11, Vol.56 (11), p.2225-2233

2016

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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4425-4436

2006

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A Tribute to Ronald T. Borchardt—Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.370-385

2016

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Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro

Journal of pharmaceutical sciences, 2003-01, Vol.92 (1), p.21-26

2003

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Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (12), p.3611-3615

2008

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How Well Do Lipophilicity Parameters, MEEKC Microemulsion Capacity Factor, and Plasma Protein Binding Predict CNS Tissue Binding?

Journal of pharmaceutical sciences, 2012-05, Vol.101 (5), p.1932-1940

2012

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Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.718

2006

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Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Gastroenterology (New York, N.Y. 1943), 1989-02, Vol.96 (2), p.736-749

1989

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ATP Occlusion by P-Glycoprotein as a Surrogate Measure for Drug Coupling

Biochemistry (Easton), 2008-03, Vol.47 (10), p.3294-3307

2008

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Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

Gastroenterology (New York, N.Y. 1943), 1989-03, Vol.96 (3), p.736-749

1989

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P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design

Integration of in Silico and in Vitro Tools for Scaffold Optimization during Drug Discovery: Predicting P‑Glycoprotein Efflux

In Silico and in Vitro Assessment of OATP1B1 Inhibition in Drug Discovery

QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain: Incorporating P-glycoprotein Efflux as a Variable

Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

How hydrogen bonds impact P-glycoprotein transport and permeability

Rhodamine Inhibitors of P-Glycoprotein: An Amide/Thioamide “Switch” for ATPase Activity

Efficiency Gains in Tracer Identification for Nuclear Imaging: Can In Vivo LC-MS/MS Evaluation of Small Molecules Screen for Successful PET Tracers?

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Determination of the Affinity of Drugs toward Serum Albumin by Measurement of the Quenching of the Intrinsic Tryptophan Fluorescence of the Protein

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, K p,uu,brain: Incorporating P‑glycoprotein Efflux as a Variable

Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

A Tribute to Ronald T. Borchardt—Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity

How Well Do Lipophilicity Parameters, MEEKC Microemulsion Capacity Factor, and Plasma Protein Binding Predict CNS Tissue Binding?

Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

ATP Occlusion by P-Glycoprotein as a Surrogate Measure for Drug Coupling

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

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