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Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2004-07, Vol.47 (16), p.4089-4099

2004

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Cardiac protein phosphorylation : functional and pathophysiological correlates

Cardiovascular research, 1998-06, Vol.38 (3), p.559-588

RAPUNDALO, S. T

1998

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Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4063-4070

2000

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Design of a functional hexapeptide antagonist of endothelin

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3301-3303

1992

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Application of Proteomics to the Study of Cardiovascular Biology

Trends in Cardiovascular Medicine, 2001-02, Vol.11 (2), p.66-75

2001

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Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling

The FASEB journal, 2004-11, Vol.18 (14), p.1725-1727

2004

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The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.1060-1064

2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4752-4756

2005

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Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.361-368

2000

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Characterization of endothelins as chemoattractants for human neutrophils

Life sciences (1973), 1994, Vol.55 (21), p.1633-1641

1994

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Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Bioorganic & medicinal chemistry letters, 1993-10, Vol.3 (10), p.2119-2124

1993

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Nonpeptidic Potent HIV-1 Protease Inhibitors: (4-Hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes That Span P1-P2' Subsites in a Unique Mode of Binding

Journal of medicinal chemistry, 1995-03, Vol.38 (6), p.898-905

1995

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Monocyclic Endothelins: Examination of the Importance of the Individual Disulfide Rings

Journal of cardiovascular pharmacology, 1991, Vol.17 Suppl 7, p.S62-64

1991

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Design of a functional hexapeptide antagonist of endothelin. [Erratum to document cited in CA117(13):125306v]

Journal of medicinal chemistry, 1993-01, Vol.36 (2), p.304-304

1993

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An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Tetrahedron letters, 2000, Vol.41 (32), p.6041-6044

2000

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Cardiac sarcoplasmic reticulum and sarcolemmal proteins separated by two-dimensional electrophoresis: Surfactant effects on membrane solubilization

Electrophoresis, 2000-05, Vol.21 (9), p.1685-1693

2000

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Endothelin and structurally related analogs distinguish between endothelin receptor subtypes

Biochemical and biophysical research communications, 1992-03, Vol.183 (2), p.566-571

1992

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Inotropic Responses to Isoproterenol and Phosphodiesterase Inhibitors in Intact Guinea Pig Hearts: Comparison of Cyclic AMP Levels and Phosphorylation of Sarcoplasmic Reticulum and Myofibrillar Proteins

Circulation research, 1989-01, Vol.64 (1), p.104-111

1989

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The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2497-2502

1999

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Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 Modifications

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3409-3414

1998

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Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1′ modifications

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (6), p.835-840

1999

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Chapter 6. Thrombin and Factor Xa Inhibition

Annual Reports in Medicinal Chemistry, 1996, Vol.31, p.51-60

1996

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The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 2

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2503-2508

1999

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Effects of ischemia on the isolation and function of canine cardiac sarcoplasmic reticulum

Journal of molecular and cellular cardiology, 1986-08, Vol.18 (8), p.837-851

1986

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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2893-2905

1995

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Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa

Cardiac protein phosphorylation : functional and pathophysiological correlates

Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Design of a functional hexapeptide antagonist of endothelin

Application of Proteomics to the Study of Cardiovascular Biology

Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1

Characterization of endothelins as chemoattractants for human neutrophils

Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Nonpeptidic Potent HIV-1 Protease Inhibitors: (4-Hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes That Span P1-P2' Subsites in a Unique Mode of Binding

Monocyclic Endothelins: Examination of the Importance of the Individual Disulfide Rings

Design of a functional hexapeptide antagonist of endothelin. [Erratum to document cited in CA117(13):125306v]

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Cardiac sarcoplasmic reticulum and sarcolemmal proteins separated by two-dimensional electrophoresis: Surfactant effects on membrane solubilization

Endothelin and structurally related analogs distinguish between endothelin receptor subtypes

Inotropic Responses to Isoproterenol and Phosphodiesterase Inhibitors in Intact Guinea Pig Hearts: Comparison of Cyclic AMP Levels and Phosphorylation of Sarcoplasmic Reticulum and Myofibrillar Proteins

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 Modifications

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1′ modifications

Chapter 6. Thrombin and Factor Xa Inhibition

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 2

Effects of ischemia on the isolation and function of canine cardiac sarcoplasmic reticulum

Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors

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