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Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2004-07, Vol.47 (16), p.4089-4099

2004

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Cardiac protein phosphorylation : functional and pathophysiological correlates

Cardiovascular research, 1998-06, Vol.38 (3), p.559-588

RAPUNDALO, S. T

1998

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Application of Proteomics to the Study of Cardiovascular Biology

Trends in Cardiovascular Medicine, 2001-02, Vol.11 (2), p.66-75

2001

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Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4063-4070

2000

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Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling

The FASEB journal, 2004-11, Vol.18 (14), p.1725-1727

2004

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The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.1060-1064

2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4752-4756

2005

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Design of a functional hexapeptide antagonist of endothelin

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3301-3303

1992

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Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.361-368

2000

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Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

Journal of medicinal chemistry, 1992-01, Vol.35 (1), p.2-14

1992

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Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Journal of medicinal chemistry, 1992-07, Vol.35 (14), p.2562-2572

1992

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Characterization of endothelins as chemoattractants for human neutrophils

Life sciences (1973), 1994, Vol.55 (21), p.1633-1641

1994

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An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Tetrahedron letters, 2000, Vol.41 (32), p.6041-6044

2000

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Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Bioorganic & medicinal chemistry letters, 1993-10, Vol.3 (10), p.2119-2124

1993

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Nonpeptidic Potent HIV-1 Protease Inhibitors: (4-Hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes That Span P1-P2' Subsites in a Unique Mode of Binding

Journal of medicinal chemistry, 1995-03, Vol.38 (6), p.898-905

1995

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Cardiac sarcoplasmic reticulum and sarcolemmal proteins separated by two-dimensional electrophoresis: Surfactant effects on membrane solubilization

Electrophoresis, 2000-05, Vol.21 (9), p.1685-1693

2000

Volltextzugriff (PDF)

Inotropic Responses to Isoproterenol and Phosphodiesterase Inhibitors in Intact Guinea Pig Hearts: Comparison of Cyclic AMP Levels and Phosphorylation of Sarcoplasmic Reticulum and Myofibrillar Proteins

Circulation research, 1989-01, Vol.64 (1), p.104-111

1989

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In Vitro and In Vivo Antithrombotic Activity of PD-198961, a Novel Synthetic Factor Xa Inhibitor

Journal of cardiovascular pharmacology, 2004-10, Vol.44 (4), p.493-500

2004

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Monocyclic Endothelins: Examination of the Importance of the Individual Disulfide Rings

Journal of cardiovascular pharmacology, 1991, Vol.17 Suppl 7, p.S62-64

1991

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Endothelin and structurally related analogs distinguish between endothelin receptor subtypes

Biochemical and biophysical research communications, 1992-03, Vol.183 (2), p.566-571

1992

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Design of a functional hexapeptide antagonist of endothelin. [Erratum to document cited in CA117(13):125306v]

Journal of medicinal chemistry, 1993-01, Vol.36 (2), p.304-304

1993

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The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2497-2502

1999

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Effects of Quinapril, a New Angiotensin Converting Enzyme Inhibitor, on Left Ventricular Failure and Survival in the Cardiomyopathic Hamster: Hemodynamic, Morphological, and Biochemical Correlates

Circulation research, 1991-05, Vol.68 (5), p.1302-1312

1991

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Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 Modifications

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3409-3414

1998

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Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1′ modifications

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (6), p.835-840

1999

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Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa

Cardiac protein phosphorylation : functional and pathophysiological correlates

Application of Proteomics to the Study of Cardiovascular Biology

Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Design of a functional hexapeptide antagonist of endothelin

Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

Characterization of endothelins as chemoattractants for human neutrophils

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Nonpeptidic Potent HIV-1 Protease Inhibitors: (4-Hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes That Span P1-P2' Subsites in a Unique Mode of Binding

Cardiac sarcoplasmic reticulum and sarcolemmal proteins separated by two-dimensional electrophoresis: Surfactant effects on membrane solubilization

Inotropic Responses to Isoproterenol and Phosphodiesterase Inhibitors in Intact Guinea Pig Hearts: Comparison of Cyclic AMP Levels and Phosphorylation of Sarcoplasmic Reticulum and Myofibrillar Proteins

In Vitro and In Vivo Antithrombotic Activity of PD-198961, a Novel Synthetic Factor Xa Inhibitor

Monocyclic Endothelins: Examination of the Importance of the Individual Disulfide Rings

Endothelin and structurally related analogs distinguish between endothelin receptor subtypes

Design of a functional hexapeptide antagonist of endothelin. [Erratum to document cited in CA117(13):125306v]

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Effects of Quinapril, a New Angiotensin Converting Enzyme Inhibitor, on Left Ventricular Failure and Survival in the Cardiomyopathic Hamster: Hemodynamic, Morphological, and Biochemical Correlates

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 Modifications

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1′ modifications

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