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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Pharmaceutics, 2024-05, Vol.16 (5), p.660

2024

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T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

PloS one, 2018-07, Vol.13 (7), p.e0201103-e0201103

2018

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T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade

PloS one, 2010-12, Vol.5 (12), p.e14450-e14450

2010

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Successful Development of Nonclinical Anti-Drug Antibody Assays to Support Zinpentraxin Alfa Reproductive Toxicology Studies

The AAPS journal, 2024-01, Vol.26 (1), p.16-16, Article 16

2024

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Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa

Reproductive toxicology (Elmsford, N.Y.), 2024-01, Vol.123, p.108526-108526, Article 108526

2024

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Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

Science translational medicine, 2021-05, Vol.13 (593)

2021

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Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship

The Journal of pharmacology and experimental therapeutics, 2006-05, Vol.317 (2), p.820

2006

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Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy

Toxicology and applied pharmacology, 2024-02, Vol.483, p.116837-116837, Article 116837

2024

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Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey

Regulatory toxicology and pharmacology, 2024-06, Vol.150, p.105630-105630, Article 105630

2024

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In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection

Toxicological sciences, 2019-06, Vol.169 (2), p.409-421

2019

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2-Arachidonoyl-glycerol suppresses interferon-γ production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2

Journal of leukocyte biology, 2005-06, Vol.77 (6), p.966-974

2005

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Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy

International journal of toxicology, 2016-05, Vol.35 (3), p.263-273

2016

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Induction of intracellular calcium elevation by Δ9-tetrahydrocannabinol in T cells involves TRPC1 channels

Journal of leukocyte biology, 2006-01, Vol.79 (1), p.202-213

2006

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Cannabinol Enhancement of Interleukin-2 (IL-2) Expression by T Cells Is Associated with an Increase in IL-2 Distal Nuclear Factor of Activated T Cell Activity

Molecular pharmacology, 2002-02, Vol.61 (2), p.446-454

2002

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Cannabinoid receptor-mediated regulation of intracellular calcium by Δ9-tetrahydrocannabinol in resting T cells

Journal of leukocyte biology, 2004-05, Vol.75 (5), p.884-892

2004

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Rac, PAK, and eNOS ACTion

Circulation research, 2008-08, Vol.103 (4), p.328-330

2008

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Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells

Journal of leukocyte biology, 2004-05, Vol.75 (5), p.884-892

2004

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Induction of intracellular calcium elevation by Delta9-tetrahydrocannabinol in T cells involves TRPC1 channels

Journal of leukocyte biology, 2006-01, Vol.79 (1), p.202-213

2006

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LFA‐1 engagement‐induced T cell cytokine mRNA stabilization involves a Rac, p38 MAP kinase, MK2 cascade

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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Chapter 13 - Biological Therapies for Cancer

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics, 2013, p.303-342

2013

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Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

The New England journal of medicine, 2015-07, Vol.373 (3), p.220-231

2015

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Correlation of subendometrial-endometrial blood flow assessment by two-dimensional power Doppler with pregnancy outcome in frozen-thawed embryo transfer cycles

Journal of human reproductive sciences, 2014-04, Vol.7 (2), p.130-135

2014

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Multiphase Multi-Detector Row Computed Tomography Imaging Characteristics of Large (>5 cm) Focal Hepatocellular Carcinoma

Journal of computer assisted tomography, 2016-05, Vol.40 (3), p.493-497

2016

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Impact of Night and Weekend Upper Endoscopy on Outcomes in Intensive Care Unit Patients With Upper Gastrointestinal Bleeding: 539

The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S309-S310

2018

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Predictors of mortality and endoscopic intervention in patients with upper gastrointestinal bleeding in the intensive care unit

Gastroenterology report, 2020-08, Vol.8 (4), p.299-305

2020

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade

Successful Development of Nonclinical Anti-Drug Antibody Assays to Support Zinpentraxin Alfa Reproductive Toxicology Studies

Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship

Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy

Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey

In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection

2-Arachidonoyl-glycerol suppresses interferon-γ production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2

Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy

Induction of intracellular calcium elevation by Δ9-tetrahydrocannabinol in T cells involves TRPC1 channels

Cannabinol Enhancement of Interleukin-2 (IL-2) Expression by T Cells Is Associated with an Increase in IL-2 Distal Nuclear Factor of Activated T Cell Activity

Cannabinoid receptor-mediated regulation of intracellular calcium by Δ9-tetrahydrocannabinol in resting T cells

Rac, PAK, and eNOS ACTion

Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells

Induction of intracellular calcium elevation by Delta9-tetrahydrocannabinol in T cells involves TRPC1 channels

LFA‐1 engagement‐induced T cell cytokine mRNA stabilization involves a Rac, p38 MAP kinase, MK2 cascade

Chapter 13 - Biological Therapies for Cancer

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

Correlation of subendometrial-endometrial blood flow assessment by two-dimensional power Doppler with pregnancy outcome in frozen-thawed embryo transfer cycles

Multiphase Multi-Detector Row Computed Tomography Imaging Characteristics of Large (>5 cm) Focal Hepatocellular Carcinoma

Impact of Night and Weekend Upper Endoscopy on Outcomes in Intensive Care Unit Patients With Upper Gastrointestinal Bleeding: 539

Predictors of mortality and endoscopic intervention in patients with upper gastrointestinal bleeding in the intensive care unit

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